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Protein Page:
DR6 (human)

Overview
DR6 May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N- terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Associates with TRADD. Interacts with N-APP. Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine; Apoptosis
Cellular Component: integral to plasma membrane; axon; plasma membrane; intrinsic to plasma membrane
Molecular Function: protein binding
Biological Process: myelination; adaptive immune response; neuron apoptosis; negative regulation of T cell proliferation; negative regulation of myelination; apoptosis; regulation of oligodendrocyte differentiation; B cell apoptosis; cellular lipid metabolic process; negative regulation of B cell proliferation; T cell receptor signaling pathway; humoral immune response
Reference #:  O75509 (UniProtKB)
Alt. Names/Synonyms: BM-018; Death receptor 6; DR6; MGC31965; TNFR-related death receptor 6; TNFRSF21; TNR21; Tumor necrosis factor receptor superfamily member 21; tumor necrosis factor receptor superfamily, member 21
Gene Symbols: TNFRSF21
Molecular weight: 71,845 Da
Basal Isoelectric point: 8.09  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease
Select Structure to View Below

DR6

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S7 _MGTSPSSSTALASC
0 1 S15 STALASCSRIARRAT
0 3 S386-p KGPRQDPsAIVEKAG
0 4 Y434-p GSQWKDIyQFLCNAS
0 14 Y460-p TADHERAyAALQHWT
0 3 S541-p ALLTVEPsPQDKNKG
0 23 S562-p EPLLRCDstssGssA
0 8 T563-p PLLRCDstssGssAL
0 7 S564-p LLRCDstssGssALS
0 8 S565-p LRCDstssGssALSR
0 4 S567-p CDstssGssALSRNG
0 7 S568-p DstssGssALSRNGS
0 4 Y648-p QTLLDSVySHLPDLL
7616 : Phospho-DR6 (Ser562) Antibody
  mouse

 
S7-p _MGTRASsITALASC
S15-p ITALASCsRTAGQVG
S386-p KGPRQDPsAIVEKAG
Y434 GSQWKDIYQFLCNAS
Y460 TADHERAYAALQHWT
S541-p TLLTVEPsPLDKNKC
S562-p EPLLRCDsTSSGSSA
T563 PLLRCDsTSSGSSAL
S564 LLRCDsTSSGSSALS
S565 LRCDsTSSGSSALSR
S567 CDsTSSGSSALSRNG
S568 DsTSSGSSALSRNGS
Y648 QTLLDSVYSHLPDLL
7616 : Phospho-DR6 (Ser562) Antibody
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