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PBK (human)

Overview PBK Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Interacts with DLG1 and TP53. Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules. Activated by phosphorylation. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase kinase subfamily. Note: This description may include information from UniProtKB. Protein type: Cancer Testis Antigen (CTA); Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.12.2; Protein kinase, Other; Other group; TOPK family Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding Biological Process: mitosis; protein amino acid phosphorylation Reference #:  Q96KB5 (UniProtKB) Alt. Names/Synonyms: Cancer/testis antigen 84; CT84; FLJ14385; Lymphokine-activated killer T-cell-originated protein kinase; MAPKK-like protein kinase; Nori-3; PBK; PDZ binding kinase; PDZ-binding kinase; serine/threonine protein kinase; Spermatogenesis-related protein kinase; SPK; T-LAK cell-originated protein kinase; TOPK Gene Symbols: PBK Molecular weight: 36,085 Da Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PBK

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	Sites Implicated In
cytoskeletal reorganization: T9‑p enzymatic activity, induced: T9‑p molecular association, regulation: T9‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
4	4		T9-p	EGISNFKtPSkLSEk
0	4		K12-a	SNFKtPSkLSEkkKs
0	3		K16-a	tPSkLSEkkKsVLCs
0	1		K17-a	PSkLSEkkKsVLCst
0	7		S19-p	kLSEkkKsVLCstPt
0	3		S23-p	kkKsVLCstPtINIP
0	24		T24-p	kKsVLCstPtINIPA
0	2		T26-p	sVLCstPtINIPAsP
0	27		S32-p	PtINIPAsPFMQKLG
0	2		Y47-p	FGTGVNVyLMkRSPR
0	1		K50-u	GVNVyLMkRSPRGLS
0	17		S59-p	SPRGLSHsPWAVKKI
0	157		Y74-p	NPICNDHyRsVyQKR
0	1		S76-p	ICNDHyRsVyQKRLM
0	1		Y78-p	NDHyRsVyQKRLMDE
0	1		K90-u	MDEAKILkSLHHPNI
0	1		Y100-p	HHPNIVGyRAFTEAN
0	1		S122	MEYGGEKSLNDLIEE
0	2		K132-u	DLIEERYkASQDPFP
0	1		K169-u	KLLHGDIkSSNVVIK
1	0		T198	LPLDENMTVTDPEAC
0	1		P280	AALGTRPPINMEELD

	mouse
T9-p	EGINNFKtPNKSEKR
K12	NNFKtPNKSEKRKsV
K15	KtPNKSEKRKsVLCs
R16	tPNKSEKRKsVLCst
S18-p	NKSEKRKsVLCstPC
S22-p	KRKsVLCstPCVNIP
T23-p	RKsVLCstPCVNIPA
C25	sVLCstPCVNIPAsP
S31-p	PCVNIPAsPFMQKLG
Y46	FGTGVSVYLMKRSPR
K49	GVSVYLMKRSPRGLS
S58-p	SPRGLSHsPWAVKKI
Y73	SLLCDDHYRTVYQKR
T75	LCDDHYRTVYQKRLT
Y77	DDHYRTVYQKRLTDE
K89	TDEAKILKNLNHPNI
Y99	NHPNIIGYRAFTEAS
S121-p	MEYGGEKsLNDLIEE
K131	DLIEERNKDSGSPFP
K168	KLLHGDIKSSNVVIK
T197-p	LPLDENMtVTDPEAC
S279-p	AALGTRPsINMEELD

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