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Protein Page:
PBK (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PBK Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Interacts with DLG1 and TP53. Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules. Activated by phosphorylation. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase kinase subfamily. Note: This description may include information from UniProtKB.
Protein type: Cancer Testis Antigen (CTA); Kinase, protein; EC 2.7.12.2; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Other group; TOPK family
Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding
Biological Process: mitosis
Reference #:  Q96KB5 (UniProtKB)
Alt. Names/Synonyms: Cancer/testis antigen 84; CT84; FLJ14385; Lymphokine-activated killer T-cell-originated protein kinase; MAPKK-like protein kinase; Nori-3; PBK; PDZ binding kinase; PDZ-binding kinase; Spermatogenesis-related protein kinase; SPK; T-LAK cell-originated protein kinase; TOPK
Gene Symbols: PBK
Molecular weight: 36,085 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PBK

Protein Structure Not Found.


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Sites Implicated In
cytoskeletal reorganization: T9‑p
enzymatic activity, induced: T9‑p
molecular association, regulation: T9‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
4 5 T9-p EGISNFKtPSkLsEk
0 4 K12-a SNFKtPSkLsEkKKs
0 2 S14-p FKtPSkLsEkKKsVL
0 3 K16-a tPSkLsEkKKsVLCs
0 7 S19-p kLsEkKKsVLCstPt
0 4 S23-p kKKsVLCstPtINIP
0 25 T24-p KKsVLCstPtINIPA
0 2 T26-p sVLCstPtINIPAsP
0 29 S32-p PtINIPAsPFMQKLG
0 2 Y47-p FGTGVNVyLMKRSPR
0 20 S59-p SPRGLSHsPWAVKKI
0 158 Y74-p NPICNDHyRSVYQKR
0 1 K90-u MDEAKILksLHHPNI
0 1 S91-p DEAKILksLHHPNIV
0 1 S122 MEYGGEKSLNDLIEE
0 2 K132-u DLIEERYkASQDPFP
1 0 T198 LPLDENMTVTDPEAC
4941 : Phospho-PBK/TOPK (Thr9) Antibody
  mouse

 
T9-p EGINNFKtPNKSEKR
K12 NNFKtPNKSEKRKsV
S13 NFKtPNKSEKRKsVL
K15 KtPNKSEKRKsVLCs
S18-p NKSEKRKsVLCstPC
S22-p KRKsVLCstPCVNIP
T23-p RKsVLCstPCVNIPA
C25 sVLCstPCVNIPAsP
S31-p PCVNIPAsPFMQKLG
Y46 FGTGVSVYLMKRSPR
S58-p SPRGLSHsPWAVKKI
Y73 SLLCDDHYRTVYQKR
K89 TDEAKILKNLNHPNI
N90 DEAKILKNLNHPNII
S121-p MEYGGEKsLNDLIEE
K131 DLIEERNKDSGSPFP
T197-p LPLDENMtVTDPEAC
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