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Protein Page:
FANCB (human)

FANCB DNA repair protein required for FANCD2 ubiquitination. Defects in FANCB are the cause of Fanconi anemia complementation group B (FANCB). It is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Some severe FANCB cases manifest features of VACTERL syndrome with hydrocephalus. Note: This description may include information from UniProtKB.
Cellular Component: nucleoplasm
Molecular Function: protein binding
Biological Process: DNA repair
Reference #:  Q8NB91 (UniProtKB)
Alt. Names/Synonyms: FA2; FAAP90; FAAP95; FAB; FACB; FANCB; Fanconi anemia group B protein; Fanconi anemia, complementation group B; Fanconi anemia-associated polypeptide of 95 kDa; Protein FACB; type 2 Fanconi pancytopenia
Gene Symbols: FANCB
Molecular weight: 97,726 Da
Basal Isoelectric point: 7.79  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

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SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.



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