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Protein Page:
WHRN (mouse)

Overview
WHRN Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Defects in WHRN are the cause of deafness autosomal recessive type 31 (DFNB31). DFNB31 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Defects in WHRN are the cause of Usher syndrome type 2D (USH2D). USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH2 is characterized by congenital mild hearing impairment with normal vestibular responses. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: photoreceptor inner segment; dendrite; actin filament; cilium; stereocilium; cell projection; stereocilium bundle; cell soma; membrane; axon; cytoplasm; synapse; dendritic shaft; photoreceptor connecting cilium
Molecular Function: protein domain specific binding; protein binding
Biological Process: retinal homeostasis; inner ear receptor stereocilium organization and biogenesis; sensory perception of sound; sensory perception of light stimulus
Reference #:  Q80VW5 (UniProtKB)
Alt. Names/Synonyms: 1110035G07Rik; AW122018; AW742671; bM340H1.8; C430046P22Rik; Kiaa1526; MGC183668; mKIAA1526; OTTMUSP00000000316; OTTMUSP00000000317; OTTMUSP00000019121; OTTMUSP00000019122; whirler; Whirlin; Whrn; wi
Gene Symbols: Whrn
Molecular weight: 98,012 Da
Basal Isoelectric point: 8.2  Predict pI for various phosphorylation states
Select Structure to View Below

WHRN

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

► Hide Isoforms
 
0 1 S246 DPQGRSTSPPSSLPQ
0 2 S412 FYKGPAGSQVTLSSL
0 1 S696 GPFPRVQSPPHLKSP
0 1 S767-p TLSQLSDsGQtLsED
0 1 T770-p QLSDsGQtLsEDsGV
0 1 S772-p SDsGQtLsEDsGVDA
0 1 S775-p GQtLsEDsGVDAGEt
0 1 T782-p sGVDAGEtEAstSGR
0 1 S785-p DAGEtEAstSGRGRQ
0 1 T786-p AGEtEAstSGRGRQT
0 1 N798 RQTASAKNKNGKEQP
  WHRN iso5  
- gap
S55 FYKGPAGSQVTLSSL
S328 GPFPRVQSPPHLKSP
S399 TLSQLSDSGQTLSED
T402 QLSDSGQTLSEDSGV
S404 SDSGQTLSEDSGVDA
S407 GQTLSEDSGVDAGET
T414 SGVDAGETEASTSGR
S417 DAGETEASTSGRGRQ
T418 AGETEASTSGRGRQT
N430 RQTASAKNKNGKEQP
  human

 
S245-p DPQGRSIsPPSGLPQ
S411-p FYKGPAGsQVTLSSL
S685-p GPFPRVQsPPHLKSP
S756 TLSHLSDSGQTLSED
T759 HLSDSGQTLSEDSGV
S761 SDSGQTLSEDSGVDA
S764 GQTLSEDSGVDAGEA
A771 SGVDAGEAEASAPGR
S774 DAGEAEASAPGRGRQ
A775 AGEAEASAPGRGRQS
S787-p RQSVSTKsRSSKELP
  rat

 
S246 DPQGRSTSPPSSLPH
S410 FYKGPAGSQVTLSSL
S698 GPFPRVQSPPHLKSP
S769 TLSQLSDSGQTLSED
T772 QLSDSGQTLSEDSGV
S774 SDSGQTLSEDSGVDA
S777 GQTLSEDSGVDAGET
T784 SGVDAGETEASTSGR
S787 DAGETEASTSGRGRQ
T788 AGETEASTSGRGRQT
N800 RQTANTKNKNGKELP
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