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Protein Page:
WHRN (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
WHRN Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Defects in WHRN are the cause of deafness autosomal recessive type 31 (DFNB31). DFNB31 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Defects in WHRN are the cause of Usher syndrome type 2D (USH2D). USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH2 is characterized by congenital mild hearing impairment with normal vestibular responses. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: photoreceptor inner segment; dendrite; actin filament; cilium; stereocilium; stereocilium bundle; cell projection; cell soma; membrane; axon; cytoplasm; synapse; dendritic shaft; photoreceptor connecting cilium
Molecular Function: protein domain specific binding; protein binding
Biological Process: retinal homeostasis; inner ear receptor stereocilium organization and biogenesis; sensory perception of sound; sensory perception of light stimulus
Reference #:  Q80VW5 (UniProtKB)
Alt. Names/Synonyms: 1110035G07Rik; AW122018; AW742671; bM340H1.8; C430046P22Rik; Kiaa1526; MGC183668; mKIAA1526; OTTMUSP00000000316; OTTMUSP00000000317; OTTMUSP00000019121; OTTMUSP00000019122; whirler; Whirlin; Whrn; wi
Gene Symbols: Whrn
Molecular weight: 98,012 Da
Basal Isoelectric point: 8.2  Predict pI for various phosphorylation states
Select Structure to View Below

WHRN

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

► Hide Isoforms
 
0 1 - gap
0 1 - gap
0 1 - gap
0 1 K210-ac AEAVKALkGSkKLVL
0 1 K213-ac VKALkGSkKLVLSVY
0 1 Y235 GYVTNHIYTWVDPQG
0 1 S246 DPQGRSTSPPSSLPQ
0 2 S412 FYKGPAGSQVTLSSL
0 1 T436-p DQARHLLtEQERATM
0 1 S503 VLRREIESMKARQPP
0 1 Y518 GPGVGDTYSMVSYSD
0 1 S522 GDTYSMVSYSDTGSS
0 1 T526 SMVSYSDTGSSTGSH
0 1 T530 YSDTGSSTGSHGTST
0 1 P584 SVDDVKSPSEDLPGI
0 1 P589 KSPSEDLPGIKPPPP
0 1 S696 GPFPRVQSPPHLKSP
0 1 S767-p TLSQLSDsGQtLsED
0 1 T770-p QLSDsGQtLsEDsGV
0 1 S772-p SDsGQtLsEDsGVDA
0 1 S775-p GQtLsEDsGVDAGEt
0 1 T782-p sGVDAGEtEAstSGR
0 1 S785-p DAGEtEAstSGRGRQ
0 1 T786-p AGEtEAstSGRGRQT
0 1 N798 RQTASAKNKNGKEQP
0 1 K886 NGQTLRGKEHKEAAR
  WHRN iso5  
S33-p RSHSLPRsLDssGLC
S36-p SLPRsLDssGLCPSV
S37-p LPRsLDssGLCPSVF
- gap
- gap
- gap
- gap
S55 FYKGPAGSQVTLSSL
T79 DQARHLLTEQERATM
S146 VLRREIESMKARQPP
Y161 GPGVGDTYSMVSYSD
S165 GDTYSMVSYSDTGSS
T169 SMVSYSDTGSSTGSH
T173 YSDTGSSTGSHGTST
P216 SVDDVKSPSEDLPGI
P221 KSPSEDLPGIKPPPP
S328 GPFPRVQSPPHLKSP
S399 TLSQLSDSGQTLSED
T402 QLSDSGQTLSEDSGV
S404 SDSGQTLSEDSGVDA
S407 GQTLSEDSGVDAGET
T414 SGVDAGETEASTSGR
S417 DAGETEASTSGRGRQ
T418 AGETEASTSGRGRQT
N430 RQTASAKNKNGKEQP
K518 NGQTLRGKEHKEAAR
  human

 
- gap
- gap
- gap
K209 AEAVKALKGSKKLVL
K212 VKALKGSKKLVLSVY
Y234-p GYVTNHIyTWVDPQG
S245-p DPQGRSIsPPSGLPQ
S411-p FYKGPAGsQVTLSSL
N435 EQARHLLNEQEHATM
S502 VLRREIESMKARQPP
Y517-p GPGAGDTySMVsYSD
S521-p GDTySMVsYSDtGSS
T525-p SMVsYSDtGSStGSH
T529-p YSDtGSStGSHGTST
T572-p SVDDVRStSQGLsSF
S577-p RStSQGLsSFKPLPR
S685-p GPFPRVQsPPHLKSP
S756 TLSHLSDSGQTLSED
T759 HLSDSGQTLSEDSGV
S761 SDSGQTLSEDSGVDA
S764 GQTLSEDSGVDAGEA
A771 SGVDAGEAEASAPGR
S774 DAGEAEASAPGRGRQ
A775 AGEAEASAPGRGRQS
S787-p RQSVSTKsRSSKELP
K875-ac NGLTLRGkEHREAAR
  rat

 
- gap
- gap
- gap
K210 AEAVKALKGSKKLVL
K213 VKALKGSKKLVLSVY
Y235 GYVTNHIYTWVDPQG
S246 DPQGRSTSPPSSLPH
S410 FYKGPAGSQVTLSSL
T434 DQARHLLTEQERATM
S501-p VLRREIEsMKARQPP
Y516 GPGVGDTYSMVSYSD
S520 GDTYSMVSYSDTGSS
T524 SMVSYSDTGSSTGSH
T528 YSDTGSSTGSHGTST
P582 SVDDVRSPSEDLPGI
P587 RSPSEDLPGIKPPPP
S698 GPFPRVQSPPHLKSP
S769 TLSQLSDSGQTLSED
T772 QLSDSGQTLSEDSGV
S774 SDSGQTLSEDSGVDA
S777 GQTLSEDSGVDAGET
T784 SGVDAGETEASTSGR
S787 DAGETEASTSGRGRQ
T788 AGETEASTSGRGRQT
N800 RQTANTKNKNGKELP
K888 NGQTLRGKEHREAAR
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