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Protein Page:
PDZD3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PDZD3 Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion
Cellular Component: apical part of cell; subapical complex; cytosol; brush border
Molecular Function: protein C-terminus binding; protein binding; guanylate cyclase inhibitor activity; ion channel inhibitor activity
Biological Process: cGMP-mediated signaling; water transport; receptor guanylyl cyclase signaling pathway; negative regulation of guanylate cyclase activity; response to toxin; ion transport; negative regulation of cGMP biosynthetic process
Reference #:  Q86UT5 (UniProtKB)
Alt. Names/Synonyms: FLJ22756; IKEPP; intestinal and kidney enriched PDZ protein; Intestinal and kidney-enriched PDZ protein; Na(+)/H(+) exchange regulatory cofactor NHE-RF4; Na/Pi cotransporter C-terminal-associated protein 2; NaPi-Cap2; Natrium-phosphate cotransporter IIa C-terminal-associated protein 2; NHERF-4; NHERF4; NHRF4; PDZ domain containing 2; PDZ domain containing 3; PDZ domain-containing protein 2; PDZ domain-containing protein 3; PDZD3; PDZK2; Sodium-hydrogen exchanger regulatory factor 4
Gene Symbols: PDZD3
Molecular weight: 61,032 Da
Basal Isoelectric point: 6.24  Predict pI for various phosphorylation states
Select Structure to View Below

PDZD3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K276 VNGVSVEKFTHNQLT
0 1 K347 GFLLREEKGLDGRPG
1 0 S395-p LGHEETVsRIQGQGS
  mouse

 
K210-u VNGASVEkLTYNQLN
K281-u GFLLREEkGLDGRLG
S329 LGHEETVSRIRAQGS
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