Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: apical part of cell; subapical complex; cytosol; brush border
Molecular Function: protein C-terminus binding; protein binding; guanylate cyclase inhibitor activity; ion channel inhibitor activity
Biological Process: cGMP-mediated signaling; water transport; response to toxin; negative regulation of guanylate cyclase activity; receptor guanylyl cyclase signaling pathway; ion transport; negative regulation of cGMP biosynthetic process
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.