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Protein Page:
LAMA3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LAMA3 Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Defects in LAMA3 are a cause of epidermolysis bullosa junctional Herlitz type (H-JEB); also known as junctional epidermolysis bullosa Herlitz-Pearson type. JEB defines a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement membrane. H-JEB is a severe, infantile and lethal form. Death occurs usually within the first six months of life. Occasionally, children survive to teens. H-JEB is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic. Defects in LAMA3 are the cause of laryngoonychocutaneous syndrome (LOCS). LOCS is an autosomal recessive epithelial disorder confined to the Punjabi Muslim population. The condition is characterized by cutaneous erosions, nail dystrophy and exuberant vascular granulation tissue in certain epithelia, especially conjunctiva and larynx. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted
Chromosomal Location of Human Ortholog: 18q11.2
Cellular Component: laminin-5 complex; laminin-1 complex; extracellular region; basement membrane
Molecular Function: structural molecule activity; receptor binding
Biological Process: regulation of cell adhesion; extracellular matrix disassembly; epidermis development; hemidesmosome assembly; extracellular matrix organization and biogenesis; regulation of embryonic development; cell adhesion; regulation of cell migration
Reference #:  Q16787 (UniProtKB)
Alt. Names/Synonyms: BM600; BM600 150kD subunit; E170; Epiligrin 170 kDa subunit; epiligrin alpha 3 subunit; Epiligrin subunit alpha; kalinin 165kD subunit; Kalinin subunit alpha; LAMA3; lama3a; Laminin subunit alpha-3; laminin, alpha 3; laminin, alpha 3 (nicein (150kD), kalinin (165kD), BM600 (150kD), epilegrin); laminin-5 alpha 3 chain; Laminin-5 subunit alpha; Laminin-6 subunit alpha; Laminin-7 subunit alpha; LAMNA; LOCS; nicein 150kD subunit; Nicein subunit alpha
Gene Symbols: LAMA3
Molecular weight: 366,649 Da
Basal Isoelectric point: 7.03  Predict pI for various phosphorylation states
Select Structure to View Below

LAMA3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S174 DLWVLERSVDFGSTY
0 1 T180 RSVDFGSTYSPWQYF
0 1 S274-p TLLGHLIsKAQRDPt
0 1 T281-p sKAQRDPtVTRRYYY
0 1 Y791 LFRVILRYVNPGTEA
0 1 N793 RVILRYVNPGTEAVS
0 1 S1236-p ITNCGKNsFYLDPQT
0 2 T1828-p DCDSCVMtLLNDLAt
0 2 T1835-p tLLNDLAtMGEQLRL
0 1 Y2083-p LQSDFTKyLTTADss
0 1 S2089-p KyLTTADssLLQTNI
0 1 S2090-p yLTTADssLLQTNIA
0 1 T2218-p DLPRKAKtLsSNSDK
0 1 S2220-p PRKAKtLsSNSDKLL
0 1 S2286-p GDIDAMIsSAKSMVR
0 1 S2480-p VDQILTKsEtKEAVM
0 1 T2482-p QILTKsEtKEAVMDR
0 1 Y2503-p YQFARLNyTKGATSs
0 1 S2510-p yTKGATSsKPETPGV
0 1 Y2558-p SRLSFPPyKGCIELD
0 1 T2757-p LNDTVGVtKKCSEDW
0 1 S2915-p PEVLDLTsNSLKRDV
0 1 S2923-p NSLKRDVsLGGCSLN
0 1 S2975-ga KVWQDACsPLPKTQA
0 1 T3050-p RLVFALGtDGKKLRI
0 2 S3093-p GLRAREGsLPGNSTI
  mouse

 
S171-p DLWILERsVDFGStY
T177-p RsVDFGStYSPWQYF
S271 TLLGHLISKAERDPT
T278 SKAERDPTVTRRYYY
Y788-p LFRIVLRyIsPGTEA
S790-p RIVLRyIsPGTEAIS
S1233 ISSCGGDSFYIDPQA
T1825 DCDSCVMTLLNDLAS
S1832 TLLNDLASMGEELRL
Y2080 LKNDFTKYLATADSS
S2086 KYLATADSSLLQTNN
S2087 YLATADSSLLQTNNL
T2215 DLPKRAKTLSSDSEE
S2217 PKRAKTLSSDSEELL
I2282 GDIDSVVIGAKSMVR
S2476 IDQVLTESESQEAVM
S2478 QVLTESESQEAVMDR
Y2499 YQFAKLNYTKEATST
T2506 YTKEATSTKPKAPGV
Y2554 RRLRFPPYKGCIELD
T2753 LNDTVGVTKKCSEDW
S2911 PEVLDMASKSTKRDA
F2919 KSTKRDAFLGGCSLN
S2970 EAWQDGKSCLPPLNT
A3047 HVIFALGAGGKKLRL
S3090 GLRAQEGSLPGNSTI
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