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LAMB1 (human)

Overview LAMB1 Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Note: This description may include information from UniProtKB. Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide Cellular Component: extracellular matrix; extracellular space; laminin-8 complex; laminin-1 complex; laminin-2 complex; perinuclear region of cytoplasm; laminin-10 complex; extracellular region; basement membrane Molecular Function: integrin binding; enzyme binding; extracellular matrix structural constituent; structural molecule activity; glycosphingolipid binding Biological Process: odontogenesis; axon guidance; cell migration; negative regulation of cell adhesion; cell adhesion; embryo implantation; positive regulation of epithelial cell proliferation; neurite development; positive regulation of cell migration Reference #:  P07942 (UniProtKB) Alt. Names/Synonyms: CLM; cutis laxa with marfanoid phenotype; LAMB1; Laminin B1 chain; Laminin subunit beta-1; laminin, beta 1; Laminin-1 subunit beta; Laminin-10 subunit beta; Laminin-12 subunit beta; Laminin-2 subunit beta; Laminin-6 subunit beta; Laminin-8 subunit beta; MGC142015 Gene Symbols: LAMB1 Molecular weight: 198,038 Da Basal Isoelectric point: 4.83  Predict pI for various phosphorylation states

Select Structure to View Below LAMB1 4AQS - A=22-542 (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S154-p	AMLIERSsDFGKTWG
0	1		K215-u	RALDPAFkIEDPysP
0	1		Y220-p	AFkIEDPysPRIQNL
0	1		S221-p	FkIEDPysPRIQNLL
0	1		T231-p	IQNLLKItNLRIKFV
0	1		T242-p	IKFVKLHtLGDNLLD
0	1		S250	LGDNLLDSRMEIREK
0	1		T369-p	CDDCQHNtMGRNCEQ
0	1		-	gap
0	1		S1222	PYRETVDSVERKVSE
0	2		K1310-u	AEQLEFIkNSDIRGA
0	1		S1365-p	DVMMEREsQFKEKQE
0	1		T1435-ga	PGCGGLVtVAHNAWQ
0	1		S1453	DLDQDVLSALAEVEQ
0	1		K1697	LDGELDEKYKKVENL
0	1		K1708	VENLIAKKTEESADA
0	2		S1735-p	TLLAQANsKLQLLKD
0	1		K1736	LLAQANsKLQLLKDL

	LAMB1 iso3
S154	AMLIERSSDFGKTWG
K215	RALDPAFKIEDPYSP
Y220	AFKIEDPYSPRIQNL
S221	FKIEDPYSPRIQNLL
T231	IQNLLKITNLRIKFV
T242	IKFVKLHTLGDNLLD
S250	LGDNLLDSRMEIREK
T369	CDDCQHNTMGRNCEQ
S825-p	CKRRFLKsIVMHSFR
-	gap
-	gap
-	gap
-	under review
-	gap
-	under review
-	gap
-	gap
-	under review

	mouse
S154	AMLIERSSDFGKAWG
K215	RALDPAFKIEDPYSP
Y220	AFKIEDPYSPRIQNL
S221	FKIEDPYSPRIQNLL
T231	IQNLLKITNLRIKFV
T242	IKFVKLHTLGDNLLD
S250-p	LGDNLLDsRMEIREK
T369	CDNCQHNTMGRNCEQ
-	gap
S1222-p	PYRETVDsVEKKVNE
K1310-u	AEQLEFIkNSDIQGA
S1365	DLMLERESPFKEQQE
T1435	PGCGGLVTVAHSAWQ
S1453-p	DFDRDVLsALAEVEQ
K1697-a	LDGELDEkYKKVESL
K1708-u	VESLIAQkTEESADA
S1735	TLLAQANSkLQLLED
K1736-a	LLAQANSkLQLLEDL

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