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Protein Page:
HOMER1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HOMER1 Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Interacts with IFT57. Interacts with OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization. Belongs to the Homer family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: postsynaptic membrane; costamere; cell soma; integral to plasma membrane; apical part of cell; dendritic shaft; Z disc; cell junction
Molecular Function: identical protein binding; protein heterodimerization activity; type 5 metabotropic glutamate receptor binding; protein complex scaffold
Biological Process: skeletal muscle contraction; circadian rhythm; response to nicotine; synaptic transmission; chemical homeostasis within a tissue; positive regulation of signal transduction; behavioral response to cocaine; metabotropic glutamate receptor, phospholipase C activating pathway; skeletal muscle fiber development; response to calcium ion; positive regulation of calcium ion transport
Reference #:  Q86YM7 (UniProtKB)
Alt. Names/Synonyms: HOME1; HOMER; homer homolog 1 (Drosophila); Homer protein homolog 1; homer, neuronal immediate early gene, 1; Homer-1; HOMER1; HOMER1A; HOMER1B; HOMER1C; SYN47; Ves-1
Gene Symbols: HOMER1
Molecular weight: 40,277 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HOMER1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 K22 QIDPNTKKNWVPTSK
0 1 T60 SKAIINSTITPNMTF
0 2 K73-ub TFTKTSQkFGQWADS
0 1 S138 SAGGDLQSPLTPESI
0 2 T141 GDLQSPLTPESINGT
0 3 S144 QSPLTPESINGTDDE
0 1 S174 TQNALPFSHSSAISK
0 1 S174 TQNALPFSHSSAISK
0 1 S176 NALPFSHSSAISKHW
0 1 S177 ALPFSHSSAISKHWE
0 1 K191 EAELATLKGNNAKLT
0 1 K196 TLKGNNAKLTAALLE
0 3 K209 LESTANVKQWKQQLA
0 3 K212 TANVKQWKQQLAAYQ
0 1 S237 TELECVSSQANAVHT
0 6 K299 QEVEIRNKDLEGQLS
0 2 S306 KDLEGQLSDLEQRLE
0 1 K314 DLEQRLEKSQNEQEA
0 1 K327 EAFRNNLKTLLEILD
0 8 K349 ELRDNLAKLLECS__
  mouse

 
K22-ub QIDPNTKkNWVPTSK
T60-p SKAIINStITPNMTF
K73 TFTKTSQKFGQWADS
S138-p SAGGDLQsPLtPEsI
T141-p GDLQsPLtPEsINGT
S144-p QsPLtPEsINGTDDE
S185-p GDRTQALsHAssAIS
S185-gl GDRTQALsHAssAIS
S188-p TQALsHAssAISKHW
S189-p QALsHAssAISKHWE
K203-m1 EAELATLkGNNAkLT
K208-ub TLkGNNAkLTAALLE
K221-ub LESTANVkQWkQQLA
K224-ub TANVkQWkQQLAAYQ
S249-gl TELECVSsQANAVHS
K311-ub QEVEIRNkDLEGQLs
S318-p kDLEGQLsDLEQRLE
K326-ub DLEQRLEkSQNEQEA
K339-ub EAFRSNLkTLLEILD
K361-ub ELRDNLAkLLECS__
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