Home

HOMER1 (human)

Overview HOMER1 Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Interacts with IFT57. Interacts with OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization. Belongs to the Homer family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold Cellular Component: postsynaptic membrane; costamere; integral to plasma membrane; postsynaptic density; cell junction; Z disc Biological Process: skeletal muscle contraction; synaptic transmission; positive regulation of signal transduction; metabotropic glutamate receptor, phospholipase C activating pathway; skeletal muscle fiber development; response to calcium ion Reference #:  Q86YM7 (UniProtKB) Alt. Names/Synonyms: HOME1; HOMER; homer homolog 1 (Drosophila); Homer protein homolog 1; homer, neuronal immediate early gene, 1; Homer-1; HOMER1; HOMER1A; HOMER1B; HOMER1C; SYN47; Ves-1 Gene Symbols: HOMER1 Molecular weight: 40,277 Da Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below HOMER1

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  UCSD-Nature A001138 A001139 A002500  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	4		K22	QIDPNTKKNWVPTSK
0	1		T60	SKAIINSTITPNMTF
0	2		K73-u	TFTKTSQkFGQWADS
0	1		S138	SAGGDLQSPLTPESI
0	2		T141	GDLQSPLTPESINGT
0	3		S144	QSPLTPESINGTDDE
0	1		-	gap
0	1		-	under review
0	1		S176	NALPFSHSSAISKHW
0	1		S177	ALPFSHSSAISKHWE
0	1		K191	EAELATLKGNNAKLT
0	1		K196	TLKGNNAKLTAALLE
0	3		K209	LESTANVKQWKQQLA
0	3		K212	TANVKQWKQQLAAYQ
0	1		S237	TELECVSSQANAVHT
0	6		K299	QEVEIRNKDLEGQLS
0	2		S306	KDLEGQLSDLEQRLE
0	1		K314	DLEQRLEKSQNEQEA
0	1		K327	EAFRNNLKTLLEILD
0	8		K349	ELRDNLAKLLECS__

	mouse
K22-u	QIDPNTKkNWVPTSK
T60-p	SKAIINStITPNMTF
K73	TFTKTSQKFGQWADS
S138-p	SAGGDLQsPLtPEsI
T141-p	GDLQsPLtPEsINGT
S144-p	QsPLtPEsINGTDDE
S185-p	GDRTQALsHAssAIS
S185-g	GDRTQALsHAssAIS
S188-p	TQALsHAssAISKHW
S189-p	QALsHAssAISKHWE
K203-m1	EAELATLkGNNAkLT
K208-u	TLkGNNAkLTAALLE
K221-u	LESTANVkQWkQQLA
K224-u	TANVkQWkQQLAAYQ
S249-g	TELECVSsQANAVHS
K311-u	QEVEIRNkDLEGQLs
S318-p	kDLEGQLsDLEQRLE
K326-u	DLEQRLEkSQNEQEA
K339-u	EAFRSNLkTLLEILD
K361-u	ELRDNLAkLLECS__

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.