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BCL2L2 (human)

Overview BCL2L2 Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. Expressed in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines. Belongs to the Bcl-2 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Cellular Component: mitochondrial membrane; cytosol Molecular Function: protein binding Biological Process: apoptosis; spermatogenesis; Sertoli cell proliferation; negative regulation of apoptosis Reference #:  Q92843 (UniProtKB) Alt. Names/Synonyms: Apoptosis regulator Bcl-W; B2CL2; Bcl-2-like protein 2; BCL-W; Bcl2-L-2; BCL2-like 2; BCL2-like 2 protein; BCL2L2; BCLW; KIAA0271 Gene Symbols: BCL2L2 Molecular weight: 20,746 Da Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below BCL2L2 1MK3 - A=2-171 (human) 1O0L - A=1-183 (human) 1ZY3 - A=2-171 (human) 2Y6W - A/B=1-164 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 1MK3 1O0L 1ZY3 2Y6W  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		T172-p	GNWASVRtVLtGAVA
0	1		T175-p	ASVRtVLtGAVALGA
0	1		S192-p	TVGAFFAsk______
0	1		K193-u	VGAFFAsk_______

	mouse
T172	GNWASVRTVLTGAVA
T175	ASVRTVLTGAVALGA
S192	TVGAFFASK______
K193	VGAFFASK_______

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