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Protein Page:
BCL2L2 (human)

Overview
BCL2L2 Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. Expressed in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines. Belongs to the Bcl-2 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: mitochondrial outer membrane; cytosol
Molecular Function: BH domain binding; protein binding; protein homodimerization activity; protein heterodimerization activity
Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; spermatogenesis; Sertoli cell proliferation; negative regulation of apoptosis
Reference #:  Q92843 (UniProtKB)
Alt. Names/Synonyms: Apoptosis regulator Bcl-W; B2CL2; Bcl-2-like protein 2; BCL-W; Bcl2-L-2; BCL2-like 2; BCL2-like 2 protein; BCL2L2; BCLW; KIAA0271
Gene Symbols: BCL2L2
Molecular weight: 20,746 Da
Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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BCL2L2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S192-p TVGAFFAsK______
  mouse

 
S192 TVGAFFASK______
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