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Protein Page:
GNPTG (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GNPTG the gamma subunit of N-acetylglucosamine-1-phosphotransferase. May recognize the substrate of GlcNAc-1-phosphotransferase but also lysosomal proteins with mannose-6-phosphate residues. Defects in GNPTG cause a variant of pseudo-Hurler polydystrophy, an autosomal recessive disease of lysosomal hydrolase trafficking. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: Golgi membrane; Golgi apparatus
Molecular Function: protein homodimerization activity
Biological Process: carbohydrate phosphorylation; N-glycan processing to lysosome
Reference #:  Q9UJJ9 (UniProtKB)
Alt. Names/Synonyms: C16orf27; GlcNAc-1-phosphotransferase subunit gamma; GNPTAG; GNPTG; LP2537; N-acetylglucosamine-1-phosphate transferase, gamma subunit; N-acetylglucosamine-1-phosphotransferase subunit gamma; RJD9; UDP-N-acetylglucosamine-1-phosphotransferase subunit gamma
Gene Symbols: GNPTG
Molecular weight: 33,974 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
Select Structure to View Below

GNPTG

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S15-p LLLLLGLsAGGPAPA
0 1 S133-p GDACRSRsRQSKVEL
0 1 T156 AHVSEPSTCVYALTF
0 1 K207-ub ITPQGHEkLLRTLFE
0 1 S253-p RKAHKELsKEIKRLK
0 1 T271-ga TQHGIPYtRPtEtsN
0 1 T274-ga GIPYtRPtEtsNLEH
0 1 T276-ga PYtRPtEtsNLEHLG
0 1 S277-ga YtRPtEtsNLEHLGH
0 1 T286-ga LEHLGHEtPRAKsPE
0 1 S291-ga HEtPRAKsPEQLRGD
  mouse

 
A15 FLMLLGLASQGPAPA
S133 GDSCHSRSRQSKVEL
T156-p AHVSEPStCVYALTF
K207 ITPQGYEKLLRVLFE
S253 RKAHAELSQEVQRLT
T271 QQHGIPHTQPTETTH
T274 GIPHTQPTETTHSQH
T276 PHTQPTETTHSQHLG
T277 HTQPTETTHSQHLGQ
L286 SQHLGQQLPIGAIAA
A292 QLPIGAIAAEHLRSD
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