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Protein Page:
PINK1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PINK1 Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Interats with PARK2. Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Protein kinase, Ser/Thr (non-receptor); Membrane protein, integral; Kinase, protein; Protein kinase, Other; EC 2.7.11.1; Other group; NKF2 family
Chromosomal Location of Human Ortholog: 1p36
Cellular Component: mitochondrial outer membrane; cytoskeleton; mitochondrion; membrane; perinuclear region of cytoplasm; axon; cytoplasm; mitochondrial inner membrane; TORC2 complex; mitochondrial intermembrane space; nucleus; chromatin; cytosol; integral to mitochondrial outer membrane
Molecular Function: protein kinase B binding; protein serine/threonine kinase activity; protein binding; protease activator activity; protease binding; ubiquitin protein ligase binding; magnesium ion binding; kinase activity; ATP binding
Biological Process: ubiquitin-dependent protein catabolic process; positive regulation of dopamine secretion; negative regulation of JNK cascade; positive regulation of translation; regulation of protein ubiquitination; protein ubiquitination; protein amino acid phosphorylation; positive regulation of protein amino acid dephosphorylation; regulation of mitochondrial membrane potential; positive regulation of ubiquitin-protein ligase activity; response to stress; regulation of protein complex assembly; negative regulation of neuron apoptosis; regulation of hydrogen peroxide metabolic process; mitochondrion organization and biogenesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein stabilization; activation of protein kinase B; positive regulation of synaptic transmission, dopaminergic; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; mitochondrion degradation; positive regulation of transcription factor activity; response to oxidative stress; phosphorylation
Reference #:  Q9BXM7 (UniProtKB)
Alt. Names/Synonyms: BRPK; FLJ27236; PARK6; PINK1; protein kinase BRPK; PTEN induced putative kinase 1; PTEN-induced putative kinase protein 1; Serine/threonine-protein kinase PINK1, mitochondrial
Gene Symbols: PINK1
Molecular weight: 62,769 Da
Basal Isoelectric point: 9.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PINK1

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S228‑p, S402‑p
protein conformation: S402‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K135 IQAIFTQKSKPGPDP
4 1 S228-p MWNISAGsSSEAILN
3 1 T257-p AGEYGAVtYRKSkRG
0 1 K262-ac AVtYRKSkRGPKQLA
1 0 T313-p EGLGHGRtLFLVMKN
4 1 S402-p GLQLPFSsWYVDRGG
  mouse

 
K135-ub IQAIFTQkTKRVSDP
S227 MWNISAGSSSEAILS
T256 AGEYGAVTYRRSRDG
R261 AVTYRRSRDGPKQLA
T312 EGLGHGRTLFLVMKN
S401 GLRLPFNSSSVERGG
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