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Protein Page:
PINK1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PINK1 Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Interats with PARK2. Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Mitochondrial; Other group; NKF2 family
Cellular Component: mitochondrial outer membrane; mitochondrion; mitochondrial inner membrane; integral to membrane; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; ubiquitin protein ligase binding; magnesium ion binding; kinase activity; ATP binding
Biological Process: cell death; positive regulation of dopamine secretion; peptidyl-serine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of protein ubiquitination; positive regulation of synaptic transmission, dopaminergic; mitochondrion degradation; regulation of protein complex assembly; protein ubiquitination; response to stress; negative regulation of neuron apoptosis; protein amino acid phosphorylation
Reference #:  Q9BXM7 (UniProtKB)
Alt. Names/Synonyms: BRPK; FLJ27236; PARK6; PINK1; protein kinase BRPK; PTEN induced putative kinase 1; PTEN-induced putative kinase protein 1; Serine/threonine-protein kinase PINK1, mitochondrial
Gene Symbols: PINK1
Molecular weight: 62,769 Da
Basal Isoelectric point: 9.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PINK1

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S228‑p, S402‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K135 IQAIFTQKSKPGPDP
3 1 S228-p MWNISAGsSSEAILN
2 1 T257-p AGEYGAVtYRKSKRG
1 0 T313-p EGLGHGRtLFLVMKN
3 1 S402-p GLQLPFSsWYVDRGG
  mouse

 
K135-u IQAIFTQkTKRVSDP
S227 MWNISAGSSSEAILS
T256 AGEYGAVTYRRSRDG
T312 EGLGHGRTLFLVMKN
S401 GLRLPFNSSSVERGG
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