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PINK1 (human)

Overview PINK1 Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Interats with PARK2. Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: EC 2.7.11.1; Protein kinase, Other; Kinase, protein; Mitochondrial; Protein kinase, Ser/Thr (non-receptor); Membrane protein, integral; Other group; NKF2 family Cellular Component: mitochondrial outer membrane; mitochondrion; integral to membrane; cytosol Molecular Function: protein serine/threonine kinase activity; protein binding; ubiquitin protein ligase binding; magnesium ion binding; kinase activity; ATP binding Biological Process: cell death; positive regulation of dopamine secretion; peptidyl-serine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of protein ubiquitination; positive regulation of synaptic transmission, dopaminergic; protein kinase cascade; mitochondrion degradation; regulation of protein complex assembly; response to stress; protein amino acid phosphorylation Reference #:  Q9BXM7 (UniProtKB) Alt. Names/Synonyms: BRPK; FLJ27236; PARK6; PINK1; protein kinase BRPK; PTEN induced putative kinase 1; PTEN-induced putative kinase protein 1; Serine/threonine-protein kinase PINK1, mitochondrial Gene Symbols: PINK1 Molecular weight: 62,769 Da Basal Isoelectric point: 9.43  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PINK1

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  DISEASE 605909 608309  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
intracellular localization: S228‑p, S402‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K135	IQAIFTQKSKPGPDP
1	1		S228-p	MWNISAGsSSEAILN
1	1		T257-p	AGEYGAVtYRKSkRG
0	1		K262-a	AVtYRKSkRGPKQLA
1	0		T313-p	EGLGHGRtLFLVMKN
1	1		S402-p	GLQLPFSsWYVDRGG

	mouse
K135-u	IQAIFTQkTKRVSDP
S227	MWNISAGSSSEAILS
T256	AGEYGAVTYRRSRDG
R261	AVTYRRSRDGPKQLA
T312	EGLGHGRTLFLVMKN
S401	GLRLPFNSSSVERGG

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