Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
EPO (mouse)

Overview
EPO Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Genetic variation in EPO is associated with susceptbility to microvascular complications of diabetes type 2 (MVCD2). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the EPO/TPO family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: extracellular space; cell surface; extracellular region
Molecular Function: erythropoietin receptor binding; hormone activity; protein kinase activator activity
Biological Process: heart morphogenesis; hemoglobin biosynthetic process; erythrocyte maturation; apoptosis; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; negative regulation of myeloid cell apoptosis; peptidyl-serine phosphorylation; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of protein kinase activity; positive regulation of cell proliferation; cardiac muscle morphogensis; response to hypoxia; ventricular cardiac muscle morphogenesis; erythrocyte differentiation; angiogenesis; positive regulation of Ras protein signal transduction; positive regulation of neuron differentiation; positive regulation of DNA replication; embryo implantation; negative regulation of apoptosis
Reference #:  P07321 (UniProtKB)
Alt. Names/Synonyms: Epo; Erythropoietin; OTTMUSP00000024624; OTTMUSP00000024625
Gene Symbols: Epo
Molecular weight: 21,365 Da
Basal Isoelectric point: 7.6  Predict pI for various phosphorylation states
Select Structure to View Below

EPO

Protein Structure Not Found.


STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 3 S126 LHIDKAISGLRSLTS
0 1 S130 KAISGLRSLTSLLRV
0 1 T160 PAPLRTLTVDTFCKL
  human

 
S127-p LHVDKAVsGLRsLTT
S131-p KAVsGLRsLTTLLRA
T161-p AAPLRTItADTFRKL
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.