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EPO (human)

Overview EPO Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Genetic variation in EPO is associated with susceptbility to microvascular complications of diabetes type 2 (MVCD2). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the EPO/TPO family. Note: This description may include information from UniProtKB. Protein type: Secreted; Secreted, signal peptide Cellular Component: extracellular space; extracellular region Molecular Function: protein binding; eukaryotic cell surface binding; erythropoietin receptor binding; hormone activity; protein kinase activator activity Biological Process: erythrocyte maturation; blood circulation; apoptosis; positive regulation of transcription, DNA-dependent; cellular response to stress; response to lipopolysaccharide; signal transduction; response to salt stress; response to vitamin A; positive regulation of cell proliferation; response to axon injury; response to electrical stimulus; aging; hemoglobin biosynthetic process; response to testosterone stimulus; peptidyl-serine phosphorylation; response to hyperoxia; positive regulation of tyrosine phosphorylation of Stat5 protein; response to estrogen stimulus; negative regulation of ion transmembrane transporter activity; positive regulation of Ras protein signal transduction; positive regulation of neuron differentiation; positive regulation of DNA replication; embryo implantation; negative regulation of apoptosis Reference #:  P01588 (UniProtKB) Alt. Names/Synonyms: EP; EPO; epoetin; Erythropoietin; MGC138142; MVCD2 Gene Symbols: EPO Molecular weight: 21,307 Da Basal Isoelectric point: 8.3  Predict pI for various phosphorylation states

Select Structure to View Below EPO 1BUY - A=28-193 (human) 1CN4 - C=28-193 (human) 1EER - A=28-193 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1BUY 1CN4 1EER  |  Phospho3D  |  DISEASE 133170 612623  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		S127-p	LHVDKAVsGLRsLTT
0	1		S131-p	KAVsGLRsLTTLLRA

	mouse
S126	LHIDKAISGLRSLTS
S130	KAISGLRSLTSLLRV

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