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Dok7
docking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK. Interacts with the cytoplasmic part of MUSK. Defects in DOK7 are the cause of congenital myasthenic syndrome type 1B or CMS1B. Three isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Activator protein; Adaptor/scaffold |
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Cellular Component: plasma membrane; cell junction; neuromuscular junction
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Molecular Function: protein kinase binding; insulin receptor binding; phosphoinositide binding
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Biological Process: receptor clustering; neuromuscular junction development
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Reference #:
Q18PE1 (UniProtKB)
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| Alt. Names/Synonyms: C4orf25; CMS1B; docking protein 7; DOK7; Downstream of tyrosine kinase 7; FLJ33718; FLJ39137; FLJ90556; Protein Dok-7 |
| Gene Symbols: DOK7 |
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Molecular weight: 53,097 Da
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Basal Isoelectric point: 6.43
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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