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Protein Page:
Dok7 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Dok7 docking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK. Interacts with the cytoplasmic part of MUSK. Defects in DOK7 are the cause of congenital myasthenic syndrome type 1B or CMS1B. Three isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Activator protein; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component: plasma membrane; neuromuscular junction; cell junction
Molecular Function: protein kinase binding; phosphoinositide binding; insulin receptor binding
Biological Process: receptor clustering; neuromuscular junction development
Reference #:  Q18PE1 (UniProtKB)
Alt. Names/Synonyms: C4orf25; CMS1B; docking protein 7; DOK7; Downstream of tyrosine kinase 7; FLJ33718; FLJ39137; FLJ90556; Protein Dok-7
Gene Symbols: DOK7
Molecular weight: 53,097 Da
Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states
Select Structure to View Below

Dok7

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K49 KDKSERIKGLRERSS
1 1 Y395 CLPGTVEYQVPTSLR
1 4 Y405-p PTSLRAHyDTPRSLC
0 1 S419-p CLAPRDHsPPSQGsP
0 1 S425-p HsPPSQGsPGNSAAR
  mouse

 
K49-ac KDKCERSkGLRERSS
Y396-p CPPGAAEyQVPTSLR
Y406-p PTSLRHHyDTPRSLR
S420 RQAPRDPSPASQGSS
S426 PSPASQGSSDHGSAT
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