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Protein Page:
COCH (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
COCH Plays a role in the control of cell shape and motility in the trabecular meshwork. Defects in COCH are the cause of deafness autosomal dominant type 9 (DFNA9). DFNA9 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA9 is characterized by onset in the fourth or fifth decade of life and initially involves the high frequencies. Deafness is progressive and usually complete by the sixth decade. In addition to cochlear involvement, DFNA9 patients also exhibit a spectrum of vestibular dysfunctions. Penetrance of the vestibular symptoms is often incomplete, and some patients are minimally affected, whereas others suffer from severe balance disturbances and episodes of vertigo. Affected individuals have mucopolysaccharide depositions in the channels of the cochlear and vestibular nerves. These depositions apparently cause strangulation and degeneration of dendritic fibers. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Extracellular matrix; Secreted
Cellular Component: proteinaceous extracellular matrix
Molecular Function: protein binding
Biological Process: regulation of cell shape; sensory perception of sound
Reference #:  O43405 (UniProtKB)
Alt. Names/Synonyms: coagulation factor C homolog, cochlin (Limulus polyphemus); COCH; COCH-5B2; COCH5B2; Cochlin; DFNA9
Gene Symbols: COCH
Molecular weight: 59,483 Da
Basal Isoelectric point: 8.17  Predict pI for various phosphorylation states
Select Structure to View Below

COCH

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S120-p MLSRWSAsFtVtKGK
0 1 T122-p SRWSAsFtVtKGKSs
0 1 T124-p WSAsFtVtKGKSsTQ
0 1 T124-ga WSAsFtVtKGKSsTQ
0 2 S129-p tVtKGKSsTQEATGQ
0 1 T130 VtKGKSsTQEATGQA
0 1 S139-ga EATGQAVstAHPPtG
0 1 T140-ga ATGQAVstAHPPtGK
0 1 T145-ga VstAHPPtGKRLKKT
0 1 T257-ga HTAQKFFtVDAGVRK
0 1 S300 GVNVFIVSVAKPIPE
0 1 T339-p HMPNWFGttKYVKPL
0 1 T340-p MPNWFGttKYVKPLV
  mouse

 
S122 MLSRWSASFAVTKGK
A124 SRWSASFAVTKGKSs
T126 WSASFAVTKGKSstQ
T126 WSASFAVTKGKSstQ
S131-p AVTKGKSstQEATGR
T132-p VTKGKSstQEATGRA
S141 EATGRAVSTAHPPSG
T142 ATGRAVSTAHPPSGK
S147 VSTAHPPSGKRLKKT
T259 HTAQKFFTADTGVRK
S302-p GVNVFIVsVAKPIPE
T341 HMPNWFGTTKYVKPL
T342 MPNWFGTTKYVKPLV
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