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Protein Page:
GAK (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
GAK Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; EC 2.7.11.1; Kinase, protein; Other group; NAK family
Cellular Component: Golgi apparatus; focal adhesion; intracellular membrane-bound organelle; perinuclear region of cytoplasm
Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding
Biological Process: cell cycle
Reference #:  O14976 (UniProtKB)
Alt. Names/Synonyms: cyclin G associated kinase; Cyclin-G-associated kinase; FLJ16629; FLJ40395; GAK; MGC99654
Gene Symbols: GAK
Molecular weight: 143,191 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
Select Structure to View Below

GAK

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S16-p DFLAGPGsLGGASGR
0 6 S73-p YALKRLLsNEEEKNR
0 2 K90-u IQEVCFMkKLSGHPN
0 1 K135 GQLVEFLKKMESRGP
0 1 K175-u PIIHRDLkVENLLLS
0 8 Y204-p TISHYPDySWSAQRR
0 1 K325-u AARNVNPkSPITELL
0 26 Y367-p GGLALAEyDQPyGGF
0 28 Y371-p LAEyDQPyGGFLDIL
0 15 Y403-p VIQSVANyAkGDLDI
0 3 K405-u QSVANyAkGDLDISY
0 2 K432-u EGVESALkNNIEDVR
0 1 S456-p HYAVYNLsPRTYRPS
0 3 Y615-p VASTSQEyDKMRDFK
0 2 Y764-p QPGSTAQyDAGAGsP
0 1 S770-p QyDAGAGsPEAEPtD
0 5 T776-p GsPEAEPtDsDsPPS
0 1 S778-p PEAEPtDsDsPPSSS
0 5 S780-p AEPtDsDsPPSSSAD
0 4 T794-p DASRFLHtLDWQEEK
0 1 S811-p ETGAENAsSKESEsA
0 1 S817-p AsSKESEsALMEDRD
0 22 S826-p LMEDRDEsEVsDEGG
0 24 S829-p DRDEsEVsDEGGsPI
0 5 S834-p EVsDEGGsPIssEGQ
0 1 S837-p DEGGsPIssEGQEPR
0 2 S838-p EGGsPIssEGQEPRA
0 1 S939-p EDPLLLAsPAPPLSV
0 1 A1039 DLLGGWAAWTETAAS
0 1 S1096-p LSSGLQGsPAGFPPG
0 1 R1123 SSSWQTSRPPAQGAs
0 2 S1130-p RPPAQGAsWPPQAKP
0 2 Y1149-p CTQPRPNyASNFSVI
0 1 S1176-p FAQKPKVsENDFEDL
0 1 S1185-p NDFEDLLsNQGFSSR
0 1 K1227 LLDWIEGKERNIRAL
  mouse

 
S16 DFLAGPGSLGGAAGR
S73 YALKRLLSNEEEKNR
K90-u IQEVCFLkKLSGHPN
K135-u GQLVEFLkRVECKGP
K175 PIIHRDLKVENLLLS
Y204 TISHYPDYSWSAQKR
K325 AARNVNPKAPITELL
Y365 GVLALAEYDQPYGGF
Y369 LAEYDQPYGGFLDIL
Y401 VIQSVANYAKGDLDI
K403 QSVANYAKGDLDISY
K430 EGVESAIKNNIEDVR
S454 HYAVYNLSPRIYRAS
Y613 VTTTSQEYDRMKEFK
Y762 QPGSTAQYDAEAGSP
S768 QYDAEAGSPEAEITE
T774 GSPEAEITESDSPQS
S776 PEAEITESDSPQSSS
S778 AEITESDSPQSSSTD
T792 DTNHFLHTLDWQEEK
S809-p ETGLDNTsPKESQSV
S815 TsPKESQSVLIADGD
S824-p LIADGDGsEVsDEEE
S827-p DGDGsEVsDEEEAsF
S833-p VsDEEEAsFPsEERK
P835 DEEEAsFPsEERKPG
S836-p EEEAsFPsEERKPGA
S938 EAPLLLASPVSPLGL
T1038-p DLLGGWDtWADTATP
L1095 LSSSLQGLPAGLPAG
R1122-m1 NSPWQANrPTAPGTS
S1129 rPTAPGTSWTPQAKP
- gap
S1171 FAQKPKVSENDFEDL
P1180 NDFEDLLPNQGFSKS
K1221-u LLDWIEGkERNIRAL
  rat

 
S16 DFLAGPGSLGGAAGR
S73 YALKRLLSNEEEKNR
K90 IQEVCFLKKLSGHPN
R135 GQLVEFLRRVECKGP
K175 PIIHRDLKVENLLLS
Y204 TISHYPDYSWSAQKR
K325 AARNVNPKAPITELL
Y365 GVLALAEYDQPYGGF
Y369 LAEYDQPYGGFLDIL
Y401 VIQSVANYAKGDLDI
K403 QSVANYAKGDLDISY
K430 EGVESAIKNNIEDVR
S454 HYAVYNLSPRIYRAS
Y613 VTTTSQEYDRMKEFK
Y762 QPGSTAQYDAEAGSP
S768 QYDAEAGSPEAEITE
T774 GSPEAEITESDSPQS
S776 PEAEITESDSPQSSS
S778 AEITESDSPQSSSTD
T792 DTNHFLHTLDWQEEK
S809 ETGVDNTSPKESQSN
S815 TSPKESQSNLIADGD
S824-p LIADGDGsEVsDEEE
S827-p DGDGsEVsDEEEASC
S833 VsDEEEASCPSEERK
P835 DEEEASCPSEERKPG
S836 EEEASCPSEERKPGA
S938 ETPLLLASPVSLLGV
T1038 DLLGGWDTWAETALP
L1095 LSSSLQGLPAGLPAG
R1122 NSSWQTTRPTAPGTS
S1129 RPTAPGTSWPPQAKP
- gap
S1171 FAQKPKVSENDFEDL
P1180 NDFEDLLPNQGFSKS
K1221 LLDWIEGKERNIRAL
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