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Casp14
Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin. Complex of unprocessed caspase-14 and processed 19 kDa (p19) and 10 kDa (p10) subunits. In undifferentiated keratinocytes under postconfluency growth conditions (in vitro). Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum). Expressed in keratinocytes of hair shaft and sebaceous glands. In psoriatic skin only expressed at very low levels. Belongs to the peptidase C14A family. Note: This description may include information from UniProtKB.
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| Protein type: Protease; EC 3.4.22.- |
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Cellular Component: cytoplasm; keratin filament; nucleus
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Molecular Function: cysteine-type endopeptidase activity
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Biological Process: epidermis development; apoptosis; cell differentiation; proteolysis
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Reference #:
P31944 (UniProtKB)
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| Alt. Names/Synonyms: apoptosis-related cysteine protease; CASP-14; CASP14; caspase 14, apoptosis-related cysteine peptidase; caspase 14, apoptosis-related cysteine protease; Caspase-14; Caspase-14 subunit p10; Caspase-14 subunit p19; CASPE; MGC119078; MGC119079 |
| Gene Symbols: CASP14 |
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Molecular weight: 27,680 Da
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Basal Isoelectric point: 5.44
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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