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RECQL4 (human)

Overview RECQL4 DNA-dependent ATPase. May modulate chromosome segregation. Interacts with UBR1 and UBR2. Interacts with MCM10; this interaction regulates RECQL4 unwinding activity. Up-regulated in actively dividing cells. Ubiquitously expressed, with highest levels in thymus and testis. Belongs to the helicase family. RecQ subfamily. Note: This description may include information from UniProtKB. Protein type: EC 3.6.4.12; Helicase; EC 3.6.1.- Cellular Component: cytoplasm; nucleus Molecular Function: ATP-dependent 3'-5' DNA helicase activity; zinc ion binding; bubble DNA binding; ATP binding Biological Process: multicellular organismal development; DNA strand renaturation; DNA replication; DNA repair; DNA duplex unwinding; DNA recombination Reference #:  O94761 (UniProtKB) Alt. Names/Synonyms: ATP-dependent DNA helicase Q4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ protein-like 4; RECQ4; RECQL4; RTS Gene Symbols: RECQL4 Molecular weight: 133,077 Da Basal Isoelectric point: 8.45  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RECQL4 2KMU - A=1-54 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE 218600 266280 268400 603780  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	37		S27-p	RQRGRRPsQDDVEAA
0	27		S101-p	PGRSRQGsVPDYGQR
0	2		K110-m1	PDYGQRLkANLkGTL
0	3		K114-m1	QRLkANLkGTLQAGP
0	8		S180-p	QHLQASLsQRLGSLD
0	1		S234-p	VLGPGAGsQGPEASA
0	1		S251-p	EVSIRVGsPQPSSSG
1	0		K376-a	LRSRLLRkQAWkQkW
1	0		K380-a	LLRkQAWkQkWRkkG
1	0		K382-a	RkQAWkQkWRkkGEC
1	0		K385-a	AWkQkWRkkGECFGG
1	0		K386-a	WkQkWRkkGECFGGG
0	1		K695-u	LLTLLQGkRFQNLDS
0	1		K843-u	STDFLAVkRLVQRVF
0	1		K1101-u	EERSTRLkDLLGRYF
0	1		K1154-u	LSLRPEEkFSSRAVA

	mouse
A27	RLHGRRPAKGDVEAA
S102	PKQSLLSSVQDYGKR
K111	QDYGKRLKANLKNTT
K115	KRLKANLKNTTQTGP
S181	QQLRSSLSRRLTSLD
S235	IADPDIQSEVSVQSP
S256-p	PAQVLSQsPKSINSK
K368	NRGRLLRKQVWKQKW
K372	LLRKQVWKQKWKKKQ
K374	RKQVWKQKWKKKQAA
K377	VWKQKWKKKQAAFGG
K378	WKQKWKKKQAAFGGS
D717	LVTLLQGDRFRTLDS
K865	STDFLAVKRLVQRVF
K1110	EEHSNQVKTLVSYYF
R1162	LSLRPEERFSGRAVA

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