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Protein Page:
ABCG5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ABCG5 Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Defects in ABCG5 are a cause of sitosterolemia (STSL); also known as phytosterolemia or shellfish sterolemia. It is a rare autosomal recessive disorder characterized by increased intestinal absorption of all sterols including cholesterol, plant and shellfish sterols, and decreased biliary excretion of dietary sterols into bile. Sitosterolemia patients have hypercholesterolemia, very high levels of plant sterols in the plasma, and frequently develop tendon and tuberous xanthomas, accelerated atherosclerosis and premature coronary artery disease. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Transporter, ABC family; Membrane protein, multi-pass; Transporter
Chromosomal Location of Human Ortholog: 2p21
Cellular Component: apical plasma membrane; integral to membrane; plasma membrane
Molecular Function: protein binding; protein heterodimerization activity; cholesterol transporter activity; ATPase activity; ATP binding
Biological Process: response to drug; ATP catabolic process; negative regulation of cholesterol absorption; cholesterol homeostasis; cholesterol absorption; cholesterol efflux; response to ionizing radiation; excretion; transmembrane transport; response to nutrient; sterol transport
Reference #:  Q9H222 (UniProtKB)
Alt. Names/Synonyms: ABCG5; ATP-binding cassette sub-family G member 5; ATP-binding cassette, sub-family G (WHITE), member 5; ATP-binding cassette, subfamily G, member 5; sterolin 1; Sterolin-1; STSL
Gene Symbols: ABCG5
Molecular weight: 72,504 Da
Basal Isoelectric point: 9.15  Predict pI for various phosphorylation states
Select Structure to View Below

ABCG5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S12-p SSLTPGGsMGLQVNR
0 3 S21 GLQVNRGSQSSLEGA
0 1 S23 QVNRGSQSSLEGAPA
0 3 S24 VNRGSQSSLEGAPAT
0 1 T108-p GRLGRAGtFLGEVyV
0 1 Y114-p GtFLGEVyVNGRALR
0 1 S202-p TGERRRVsIAAQLLQ
0 1 K320 EREIETSKRVQMIES
0 1 K337 KKSAICHKtLKNIER
0 1 T338-p KSAICHKtLKNIERM
0 1 K349 IERMKHLKTLPMVPF
  mouse

 
A12 PFLSPEGARGPHINR
S21-p GPHINRGsLssLEQG
S23-p HINRGsLssLEQGSV
S24-p INRGsLssLEQGSVT
T109 GRLRRTGTLEGEVFV
F115 GTLEGEVFVNGCELR
S203 SGERRRVSIAAQLLQ
K321-ub EREIETYkRVQMLEC
K338-ub KESDIYHkILENIER
I339 ESDIYHkILENIERA
K350-ub IERARYLkTLPTVPF
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