Ubiquitin-like protein required for autophagy. Conjugated to ATG3 and ATG5. Ubiquitous. Belongs to the ATG12 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin-like modifier; Autophagy
Cellular Component: protein complex; membrane; pre-autophagosomal structure membrane; cytoplasm
Molecular Function: protein binding; APG8 conjugating enzyme activity
Biological Process: immune system process; mitochondrion degradation; innate immune response; autophagy; C-terminal protein lipidation; autophagic vacuole formation; cellular response to nitrogen starvation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.