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Protein Page:
ATG12 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ATG12 Ubiquitin-like protein required for autophagy. Conjugated to ATG3 and ATG5. Ubiquitous. Belongs to the ATG12 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Ubiquitin-like modifier
Chromosomal Location of Human Ortholog: 5q21-q22
Cellular Component: pre-autophagosomal structure membrane
Molecular Function: protein binding; APG8 conjugating enzyme activity
Biological Process: mitochondrion degradation; innate immune response; C-terminal protein lipidation; negative regulation of interferon type I production; cellular response to nitrogen starvation; autophagic vacuole formation
Reference #:  O94817 (UniProtKB)
Alt. Names/Synonyms: APG12; Apg12 (autophagy, yeast) homolog; APG12 autophagy 12-like; APG12-like; APG12L; ATG12; ATG12 autophagy related 12 homolog (S. cerevisiae); Autophagy-related protein 12; FBR93; HAPG12
Gene Symbols: ATG12
Molecular weight: 15,113 Da
Basal Isoelectric point: 5.01  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ATG12

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K60-ub KKIDILLkAVGDtPI
0 1 T65-p LLkAVGDtPIMktKK
0 2 K69-ub VGDtPIMktKKWAVE
0 1 T70-p GDtPIMktKKWAVER
0 3 K89-ub QGLIDFIkKFLKLVA
  mouse

 
K61 KKIDILLKAVGDTPI
T66 LLKAVGDTPIMKTKK
K70 VGDTPIMKTKKWAVE
T71 GDTPIMKTKKWAVER
K90-ub QGLIDFIkKFLKLVA
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