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ATG12 (human)

Overview ATG12 Ubiquitin-like protein required for autophagy. Conjugated to ATG3 and ATG5. Ubiquitous. Belongs to the ATG12 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Autophagy; Ubiquitin-like modifier Cellular Component: protein complex; pre-autophagosomal structure membrane Molecular Function: protein binding Biological Process: innate immune response; negative regulation of interferon type I production; autophagic vacuole formation Reference #:  O94817 (UniProtKB) Alt. Names/Synonyms: APG12; Apg12 (autophagy, yeast) homolog; APG12 autophagy 12-like; APG12-like; APG12L; ATG12; ATG12 autophagy related 12 homolog (S. cerevisiae); Autophagy-related protein 12; FBR93; HAPG12 Gene Symbols: ATG12 Molecular weight: 15,113 Da Basal Isoelectric point: 5.01  Predict pI for various phosphorylation states CST Pathways:  Autophagy Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ATG12 4GDK - F/C=11-43 (human) 4GDL - C=11-43 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 4GDK 4GDL  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K60-u	KKIDILLkAVGDtPI
0	1		T65-p	LLkAVGDtPIMktKK
0	2		K69-u	VGDtPIMktKKWAVE
0	1		T70-p	GDtPIMktKKWAVER
0	3		K89-u	QGLIDFIkKFLKLVA

	mouse
K61	KKIDILLKAVGDTPI
T66	LLKAVGDTPIMKTKK
K70	VGDTPIMKTKKWAVE
T71	GDTPIMKTKKWAVER
K90-u	QGLIDFIkKFLKLVA

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