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Protein Page:
CAMKK2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CAMKK2 Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin- binding domain are inactive. Seems to be involved in hippocampal activation of CREB1. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Autophagy; EC 2.7.11.17; Protein kinase, Other; Kinase, protein; Other group; CAMKK family; Meta subfamily
Cellular Component: cell projection; cytoplasm; intracellular; nucleus
Molecular Function: calmodulin binding; calmodulin-dependent protein kinase activity; protein-tyrosine kinase activity; calcium ion binding; ATP binding
Biological Process: peptidyl-tyrosine phosphorylation; positive regulation of transcription, DNA-dependent; protein amino acid autophosphorylation; MAPKKK cascade; calcium-mediated signaling; regulation of protein kinase activity; protein amino acid phosphorylation
Reference #:  Q96RR4 (UniProtKB)
Alt. Names/Synonyms: calcium/calmodulin-dependent protein kinase beta; Calcium/calmodulin-dependent protein kinase kinase 2; calcium/calmodulin-dependent protein kinase kinase 2, beta; Calcium/calmodulin-dependent protein kinase kinase beta; CaM-kinase kinase 2; CaM-kinase kinase beta; CaM-KK 2; CaM-KK beta; CAMKK; CaMKK 2; CaMKK beta; CAMKK beta protein; CAMKK2; CAMKKB; KIAA0787; KKCC2; MGC15254
Gene Symbols: CAMKK2
Molecular weight: 64,746 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
Select Structure to View Below

CAMKK2

Protein Structure Not Found.


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Sites Implicated In
phosphorylation: S511‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T85-p GQEVPLDtSGSQARP
0 2 S86 QEVPLDtSGSQARPH
0 1 A90 LDtSGSQARPHLsGR
0 4 P92 tSGSQARPHLsGRKL
0 1 S95-p SQARPHLsGRKLsLQ
0 8 S100-p HLsGRKLsLQERSQG
0 1 S105 KLsLQERSQGGLAAG
0 1 S114-p GGLAAGGsLDMNGRC
0 2 S125-p NGRCICPsLPysPVs
0 3 Y128-p CICPsLPysPVssPQ
0 38 S129-p ICPsLPysPVssPQs
0 4 S132-p sLPysPVssPQssPR
0 39 S133-p LPysPVssPQssPRL
0 12 S136-p sPVssPQssPRLPRR
0 24 S137-p PVssPQssPRLPRRP
0 5 T145-p PRLPRRPtVESHHVS
0 1 K173-ub TLKDEIGkGSYGVVK
0 1 Y176 DEIGkGSYGVVKLAy
0 1 Y183-p YGVVKLAyNENDNTy
0 13 Y190-p yNENDNTyYAMKVLS
0 1 Y191 NENDNTyYAMKVLSK
0 17 Y234-p RGPIEQVyQEIAILk
0 1 K241-ub yQEIAILkKLDHPNV
0 1 K314-ub KIIHRDIkPSNLLVG
0 1 T350-p LLSNTVGtPAFMAPE
0 1 K403-ub MCLHSKIkSQALEFP
0 2 K441 RIVVPEIKLHPWVTR
0 1 S456 HGAEPLPSEDENCTL
0 1 S474 TEEEVENSVKHIPSL
1 0 T483 KHIPSLATVILVKTM
0 2 T489 ATVILVKTMIRKRsF
0 59 S495-p KTMIRKRsFGNPFEG
0 3 S509-p GSRREERsLsAPGNL
1 29 S511-p RREERsLsAPGNLLT
0 1 T518 sAPGNLLTKKPTREC
0 4 T522 NLLTKKPTRECESLS
0 1 S564 RGSPCVESCWAPAPG
0 4 S572 CWAPAPGSPARMHPL
12818 : Phospho-CaMKK2 (Ser511) Antibody
  CAMKK2 iso3  
T85 GQEVPLDTSGSQARP
S86 QEVPLDTSGSQARPH
A90 LDTSGSQARPHLSGR
P92 TSGSQARPHLSGRKL
S95 SQARPHLSGRKLSLQ
S100 HLSGRKLSLQERSQG
S105 KLSLQERSQGGLAAG
S114 GGLAAGGSLDMNGRC
S125 NGRCICPSLPYsPVS
Y128 CICPSLPYsPVSsPQ
S129-p ICPSLPYsPVSsPQs
S132 SLPYsPVSsPQsSPR
S133-p LPYsPVSsPQsSPRL
S136-p sPVSsPQsSPRLPRR
S137 PVSsPQsSPRLPRRP
T145 PRLPRRPTVESHHVS
K173 TLKDEIGKGSYGVVK
Y176 DEIGKGSYGVVKLAY
Y183 YGVVKLAYNENDNTY
Y190 YNENDNTYYAMKVLS
Y191 NENDNTYYAMKVLSK
Y234 RGPIEQVYQEIAILK
K241 YQEIAILKKLDHPNV
K314 KIIHRDIKPSNLLVG
T350 LLSNTVGTPAFMAPE
K403 MCLHSKIKSQALEFP
K441 RIVVPEIKLHPWVTR
S456 HGAEPLPSEDENCTL
S474 TEEEVENSVKHIPSL
T483 KHIPSLATVILVKTM
T489 ATVILVKTMIRKRSF
S495 KTMIRKRSFGNPFEG
S509 GSRREERSLsAPGNL
S511-p RREERSLsAPGNLLT
T518 sAPGNLLTKQGsEDN
S522-p NLLTKQGsEDNLQGT
- gap
- gap
12818 : Phospho-CaMKK2 (Ser511) Antibody
  mouse

 
A84 GQELPLEAsDPEsRs
S85-p QELPLEAsDPEsRsP
S89-p LEAsDPEsRsPLSGR
S91-p AsDPEsRsPLSGRKM
S94 PEsRsPLSGRKMsLQ
S99-p PLSGRKMsLQEPsQG
S104-p KMsLQEPsQGGPASS
S114 GPASSSNSLDMNGRC
S125-p NGRCICPsLSYsPAs
Y128 CICPsLSYsPAssPQ
S129-p ICPsLSYsPAssPQs
S132-p sLSYsPAssPQssPR
S133-p LSYsPAssPQssPRM
S136-p sPAssPQssPRMPRR
S137-p PAssPQssPRMPRRP
T145 PRMPRRPTVESHHVS
K173 TLKDEIGKGSyGVVK
Y176-p DEIGKGSyGVVKLAY
Y183 yGVVKLAYNENDNTy
Y190-p YNENDNTyyAMKVLS
Y191-p NENDNTyyAMKVLSK
Y234 RGPIEQVYQEIAILK
K241 YQEIAILKKLDHPNV
K314 KIIHRDIKPSNLLVG
T350 LLSNTVGTPAFMAPE
K403 MCLHSKIKSQALEFP
K441 RIVVPEIKLHPWVTR
S456-p HGAEPLPsEDENCTL
S474-p TEEEVENsVKHIPSL
T483 KHIPSLATVILVKtM
T489-p ATVILVKtMIRKRsF
S495-p KtMIRKRsFGNPFEG
S509-p GSRREERsLsAPGNL
S511-p RREERsLsAPGNLLt
T518-p sAPGNLLtKKPTREW
T522 NLLtKKPTREWEPLS
S564-p KGGPCVEsWGAPAPG
S572-p WGAPAPGsPPRMPPL
12818 : Phospho-CaMKK2 (Ser511) Antibody
  rat

 
A84 GQELPLDASEPESRS
S85 QELPLDASEPESRSL
S89 LDASEPESRSLLSGG
S91 ASEPESRSLLSGGKM
S94 PESRSLLSGGKMsLQ
S99-p LLSGGKMsLQERSQG
S104 KMsLQERSQGGPASS
S113 GGPASSSSLDMNGRC
S124 NGRCICPSLSYSPAS
Y127 CICPSLSYSPASSPQ
S128 ICPSLSYSPASSPQS
S131 SLSYSPASSPQSSPR
S132 LSYSPASSPQSSPRM
S135 SPASSPQSSPRMPRR
S136 PASSPQSSPRMPRRP
T144 PRMPRRPTVESHHVS
K172 TLKDEIGKGSYGVVK
Y175 DEIGKGSYGVVKLAY
Y182 YGVVKLAYNENDNTy
Y189-p YNENDNTyYAMKVLS
Y190 NENDNTyYAMKVLSK
Y233-p RGPIEQVyQEIAILK
K240 yQEIAILKKLDHPNV
K313 KIIHRDIKPSNLLVG
T349 LLSNTVGTPAFMAPE
K402 MCLHSKIKSQALEFP
K440-ub RIVVPEIkLHPWVTR
S455 HGAEPLPSEDENCTL
S473 TEEEVENSVKHIPSL
T482-p KHIPSLAtVILVKTM
T488 AtVILVKTMIRKRsF
S494-p KTMIRKRsFGNPFEG
S508 GSRREERSLsAPGNL
S510-p RREERSLsAPGNLLT
T517 sAPGNLLTKKPTREW
T521 NLLTKKPTREWEPLS
S563 KGGPCVESCGAPAPG
S571 CGAPAPGSPPRTPPQ
12818 : Phospho-CaMKK2 (Ser511) Antibody
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