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Protein Page:
TECTA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TECTA One of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Defects in TECTA are the cause of deafness autosomal dominant type 12 (DFNA12); also known as DFNA8. DFNA12 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Defects in TECTA are the cause of deafness autosomal recessive type 21 (DFNB21). Note: This description may include information from UniProtKB.
Protein type: Extracellular matrix; Membrane protein, GPI anchor
Cellular Component: proteinaceous extracellular matrix; plasma membrane
Biological Process: sensory perception of sound; cell-matrix adhesion
Reference #:  O75443 (UniProtKB)
Alt. Names/Synonyms: Alpha-tectorin; DFNA12; DFNA8; DFNB21; TECTA; tectorin alpha
Gene Symbols: TECTA
Molecular weight: 239,527 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
Select Structure to View Below

TECTA

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S946-p CLFRLCQsGGNEsEL
0 1 S951-p CQsGGNEsELCDsVA
0 1 S956-p NEsELCDsVARYASA
0 1 T1144-p SFPKFVVtAKNEDRD
0 1 S1153-p KNEDRDPsLALWVKQ
0 3 K1693-ub QGDGYCLkLTDMKGF
0 1 S1907-p YELDIKIsLDSVVKP
0 1 T2055-p EKYSCKItCPHNsRI
0 1 S2060-p KItCPHNsRIATDYT
  mouse

 
S946 CLFRLCQSGGNESEL
S951 CQSGGNESELCDSVA
S956 NESELCDSVARYASA
T1144 SFPKFIVTAKNEDRD
S1153 KNEDRDPSLALWVKQ
K1693 QGDGYCLKLTDMKGF
S1907 YELDIKISLDSVVKP
N2055 EKYSCKINCPQNSRI
S2060 KINCPQNSRIATDYS
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