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AurA (human)

Overview AurA a member of the AUR family of kinases. A cell cycle-regulated serine/threonine protein kinase that is overexpressed in many tumor cell lines. Regulated by phosphorylation-dependent proteasomal degradation. Localized to mitotic centrosomes and spindle microtubules and is required for centrosome maturation. Loss of Aurora A leads to defective mitotic spindles and gross errors in chromosome segregation. Required for centrosome duplication and chromosome segregation. Overexpression in culture drives transformation and aneuploidy, and negatively regulates p53. Amplified or overexpressed in many tumors or cell lines. Found as a skin tumor susceptibility gene in mouse, and a human SNP in a degradation domain is weakly cancer-associated and undergoes allele-specific amplification. Inhibitors: VX-680, ZM447439, Hesperadin, SNS-595. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; AUR family Cellular Component: centrosome; spindle microtubule; perinuclear region of cytoplasm; spindle; spindle pole centrosome; midbody; cytosol; nucleus Molecular Function: protein serine/threonine kinase activity; protein binding; ubiquitin protein ligase binding; protein serine/threonine/tyrosine kinase activity; protein kinase binding; ATP binding; protein kinase activity Biological Process: mitosis; regulation of centrosome cycle; phosphoinositide-mediated signaling; positive regulation of mitosis; protein amino acid autophosphorylation; regulation of protein stability; cell cycle; protein amino acid phosphorylation; spindle organization and biogenesis; response to estradiol stimulus; cell projection organization and biogenesis; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle Reference #:  O14965 (UniProtKB) Alt. Names/Synonyms: AIK; ARK-1; ARK1; AURA; AURKA; Aurora A; Aurora kinase A; Aurora-related kinase 1; aurora/IPL1-like kinase; Aurora/IPL1-related kinase 1; AURORA2; Breast tumor-amplified kinase; breast-tumor-amplified kinase; BTAK; hARK1; IPL1-related kinase; MGC34538; serine/threonine kinase 6; serine/threonine protein kinase 15; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A; STK15; STK6; STK7 Gene Symbols: AURKA Molecular weight: 45,809 Da Basal Isoelectric point: 9.45  Predict pI for various phosphorylation states CST Pathways:  Cell Cycle: G2/M DNA Damage Checkpoint Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below AurA 1MQ4 - A=125-391 (human) 1MUO - A=107-403 (human) 1OL5 - A=122-403 (human) 1OL6 - A=122-403 (human) 1OL7 - A=122-403 (human) 2BMC - A/B/C/D/E/F=100-403 (human) 2C6D - A=124-398 (human) 2C6E - A/B=123-401 (human) 2DWB - A=122-403 (human) 2J4Z - A/B=100-403 (human) 2J50 - A/B=126-403 (human) 2NP8 - A/B=125-391 (human) 2W1C - A=122-389 (human) 2W1D - A=122-389 (human) 2W1E - A=122-389 (human) 2W1F - A=122-389 (human) 2W1G - A=122-389 (human) 2WQE - A=127-388 (human) 2WTV - A/D/C/B=122-403 (human) 2WTW - A=122-403 (human) 2X6D - A=122-403 (human) 2X6E - A=122-403 (human) 2X81 - A=126-391 (human) 2XNE - A=122-392 (human) 2XNG - A=122-403 (human) 2XRU - A=126-403 (human) 3COH - A/B=124-391 (human) 3E5A - A=125-391 (human) 3EFW - A/B=1-403 (human) 3FDN - A=123-401 (human) 3H0Y - A=124-391 (human) 3H0Z - A/C/B=124-391 (human) 3H10 - A/D/B=124-391 (human) 3HA6 - A=125-391 (human) 3K5U - A=123-401 (human) 3LAU - A=125-399 (human) 3M11 - A=123-401 (human) 3MYG - A=125-391 (human) 3NRM - A=126-403 (human) 3P9J - A=125-391 (human) 3QBN - A=124-403 (human) 3R21 - A=126-391 (human) 3R22 - A=126-391 (human) 3UNZ - A/B=123-401 (human) 3UO4 - A=123-401 (human) 3UO5 - A=123-401 (human) 3UO6 - A/B=123-401 (human) 3UOD - A=123-401 (human) 3UOH - A/B=123-401 (human) 3UOJ - A/B=123-401 (human) 3UOK - A/B=123-401 (human) 3UOL - A/B=123-401 (human) 3UP2 - A=123-401 (human) 3UP7 - A=123-401 (human) 3VAP - A=125-391 (human) 4B0G - A=122-403 (human) 4DEA - A=123-401 (human) 4DEB - A=123-401 (human) 4DED - A=123-401 (human) 4DEE - A=123-401 (human) 4DHF - A/B=126-391 (human) 3D14 - A=116-382 (mouse) 3D15 - A=116-382 (mouse) 3D2I - A=116-382 (mouse) 3D2K - A=116-382 (mouse) 3DAJ - A=116-382 (mouse) 3DJ5 - A=116-382 (mouse) 3DJ6 - A=116-382 (mouse) 3DJ7 - A=116-382 (mouse) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2DWB 2J4Z 2J50 2NP8 2W1C 2W1D 2W1E 2W1F 2W1G 2WQE 2WTV 2WTW 2X6D 2X6E 2X81 2XNE 2XNG 2XRU 3COH 3E5A 3EFW 3FDN 3H0Y 3H0Z 3H10 3HA6 3K5U 3LAU 3M11 3MYG 3NRM 3P9J 3QBN 3R21 3R22 3UNZ 3UO4 3UO5 3UO6 3UOD 3UOH 3UOJ 3UOK 3UOL 3UP2 3UP7 3VAP 4B0G 4DEA 4DEB 4DED 4DEE 4DHF  |  ENZYME  |  Phospho3D  |  DISEASE 114500 602687 603072  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell cycle regulation: T288‑p, S342‑p cytoskeletal reorganization: T288‑p, S342‑p enzymatic activity, induced: S284‑p, T287‑p, T288‑p, S342‑p protein stabilization: S51‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S10-p	RSKENCIsGPVKAtA
1	0		G11	SKENCIsGPVKAtAP
0	1		T16-p	IsGPVKAtAPVGGPK
1	0		G20	VKAtAPVGGPKRVLV
0	2		S41-p	QNPLPVNsGQAQRVL
4	1		S51-p	AQRVLCPsNSSQRVP
0	1		S67-p	QAQKLVSsHKPVQNQ
0	2		S83-p	QKQLQATsVPHPVsR
1	0		S89-p	TsVPHPVsRPLNNTQ
1	0		K97	RPLNNTQKsKQPLPs
0	1		S98-p	PLNNTQKsKQPLPsA
0	1		S104-p	KsKQPLPsAPENNPE
1	0		N109	LPsAPENNPEEELAs
1	0		A115	NNPEEELAsKQKNEE
0	1		S116-p	NPEEELAsKQKNEES
1	9		Y148-p	KGKFGNVyLAREKQS
0	1		Y197-p	HPNILRLyGyFHDAT
0	1		Y199-p	NILRLyGyFHDATRV
0	1		Y212-p	RVYLILEyAPLGTVY
0	1		S226-p	YRELQKLsKFDEQRT
0	1		S266-p	PENLLLGsAGELKIA
0	1		S278-p	KIADFGWsVHAPSsR
1	0		S283	GWsVHAPSsRRttLC
2	0		S284-p	WsVHAPSsRRttLCG
4	3		T287-p	HAPSsRRttLCGtLD
24	9		T288-p	APSsRRttLCGtLDY
0	6		T292-p	RRttLCGtLDYLPPE
3	1		S342-p	QETYKRIsRVEFTFP
0	1		S369-p	RLLKHNPsQRPMLRE
0	1		S391-p	TANSSKPsNCQNKES

	mouse
S10	RCKENCVSRPVKTTV
R11	CKENCVSRPVKTTVP
T16	VSRPVKTTVPFGPKR
G20	VKTTVPFGPKRVLVT
S40	QNLGSASSGQAQRVL
S50	AQRVLCPSNSQRVPS
G65	QAQKLGAGQKPAPKQ
S77	PKQLPAASVPRPVSR
S83	ASVPRPVSRLNNPQK
K90	SRLNNPQKNEQPAAS
N91	RLNNPQKNEQPAASG
A95	PQKNEQPAASGNDSE
D100	QPAASGNDSEKEQAS
A106	NDSEKEQASLQKTED
S107	DSEKEQASLQKTEDT
Y139	KGKFGNVYLARERQS
Y188	HPNILRLYGYFHDAT
Y190	NILRLYGYFHDATRV
Y203	RVYLILEYAPLGTVY
S217	YRELQKLSKFDEQRT
S257	PENLLLGSNGELKIA
S269	KIADFGWSVHAPSSR
S274	GWSVHAPSSRRTtMC
S275	WSVHAPSSRRTtMCG
T278	HAPSSRRTtMCGTLD
T279-p	APSSRRTtMCGTLDY
T283	RRTtMCGTLDYLPPE
S333	QETYRRISRVEFTFP
S360	RLLKHNASQRLTLAE
T383	ANSSKPPTGHTSKEP

	rat
S10	RCKENCVSRPVKSTV
R11	CKENCVSRPVKSTVP
T16	VSRPVKSTVPFGPKR
G20	VKSTVPFGPKRVLVT
S40	QHPGSASSGQAQRVL
S50	AQRVLCPSNSQRVPP
G65	QAQKPVAGQKPVLKQ
S77	LKQLPAASGPRPASR
S83	ASGPRPASRLSNPQK
K90	SRLSNPQKSEQPQPA
S91	RLSNPQKSEQPQPAA
A97	KSEQPQPAASGNNSE
N102	QPAASGNNSEKEQTS
T108	NNSEKEQTSIQKTED
S109	NSEKEQTSIQKTEDS
Y141	KGKFGNVYLAREKQS
Y190	HPNILRLYGYFHDAT
Y192	NILRLYGYFHDATRV
Y205	RVYLILEYAPLGTVY
S219	YRELQKLSKFDEQRT
S259	PENLLLGSNGELKIA
S271	KIADFGWSVHAPSSR
S276	GWSVHAPSSRRTtLC
S277	WSVHAPSSRRTtLCG
T280	HAPSSRRTtLCGTLD
T281-p	APSSRRTtLCGTLDY
T285	RRTtLCGTLDYQPPE
S335	QETYRRISRVEFTFP
S362	RLLKHNSSQRLTLAE
T385	ANSSKPPTGHNSKEA

	pig
S10	KCKENCISGLKTTVP
G11	CKENCISGLKTTVPP
T15	CISGLKTTVPPGDGP
G19	LKTTVPPGDGPKRVP
S41	QHLPSANSGQAQRVL
S51	AQRVLCPSNSSQRLP
S67	HTQKLVSSHKPVQNL
S83	QKQSQATSGPRPVSR
S89	TSGPRPVSRPLSNTQ
Q97	RPLSNTQQSEQPQPA
S98	PLSNTQQSEQPQPAA
A104	QSEQPQPAAPGNNPE
N109	QPAAPGNNPEKEAAS
A115	NNPEKEAASKQKNEE
S116	NPEKEAASKQKNEES
Y148	KGKFGNVYLAREKQS
Y197	HPNILRLYGYFHDAT
Y199	NILRLYGYFHDATRV
Y212	RVYLILEYAPLGAVY
S226	YRELQKLSKFDEQRT
S266	PENLLLGSAGELKIA
S278	KIADFGWSVHAPssR
S283-p	GWSVHAPssRRTTLC
S284-p	WSVHAPssRRTTLCG
T287	HAPssRRTTLCGTLD
T288	APssRRTTLCGTLDY
T292	RRTTLCGTLDYLPPE
S342	QETYKRISRVEFTFP
S369	RLLKHNPSHRPTLKE
S391	TANSKPASSHKKEST

	frog
P11	AVKENHKPsNVKIFH
S12-p	VKENHKPsNVKIFHP
F17	KPsNVKIFHPMtEGA
T21-p	VKIFHPMtEGAKRIP
A43	QFRPPGTAVSAQRIL
S53-p	AQRILGPsNVPQRVL
S70	AQKPILSSQKPTTQI
S89	ATQGHQSSKPQGPNE
N95	SSKPQGPNENRNPQQ
T103-p	ENRNPQQtSHSSTPN
S104	NRNPQQtSHSSTPNV
N110	tSHSSTPNVEKKGsT
S116-p	PNVEKKGsTDQGKtS
T122-p	GsTDQGKtSAVPKEE
S123	sTDQGKtSAVPKEEG
Y155-p	KGKFGNVyLARERES
Y204	HPNILRLYGYFHDAS
Y206	NILRLYGYFHDASRV
Y219	RVYLILDYAPGGELF
T233	FRELQKCTRFDDQRS
S273	PENLLLGSNGELKIA
S285	KIADFGWSVHAPSSR
S290	GWSVHAPSSRRttLC
S291	WSVHAPSSRRttLCG
T294-p	HAPSSRRttLCGTLD
T295-p	APSSRRttLCGTLDY
T299	RRttLCGTLDYLPPE
S349-p	QETYRRIsKVEFQYP
N376	KLLKHNPNHRLPLKG
Q395	PWIIKNSQLKKKDEP

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