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Protein Page:
AurA (human)

Overview
AurA a member of the AUR family of kinases. A cell cycle-regulated serine/threonine protein kinase that is overexpressed in many tumor cell lines. Regulated by phosphorylation-dependent proteasomal degradation. Localized to mitotic centrosomes and spindle microtubules and is required for centrosome maturation. Loss of Aurora A leads to defective mitotic spindles and gross errors in chromosome segregation. Required for centrosome duplication and chromosome segregation. Overexpression in culture drives transformation and aneuploidy, and negatively regulates p53. Amplified or overexpressed in many tumors or cell lines. Found as a skin tumor susceptibility gene in mouse, and a human SNP in a degradation domain is weakly cancer-associated and undergoes allele-specific amplification. Inhibitors: VX-680, ZM447439, Hesperadin, SNS-595. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; AUR family
Cellular Component: centrosome; spindle microtubule; perinuclear region of cytoplasm; spindle; midbody; spindle pole centrosome; nucleus; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; ubiquitin protein ligase binding; protein serine/threonine/tyrosine kinase activity; protein kinase binding; ATP binding; protein kinase activity
Biological Process: spindle stabilization; mitosis; regulation of centrosome cycle; phosphoinositide-mediated signaling; positive regulation of mitosis; cell projection organization and biogenesis; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; protein amino acid autophosphorylation; regulation of protein stability; mitotic cell cycle; G2/M transition of mitotic cell cycle; negative regulation of protein binding; cell cycle; protein amino acid phosphorylation; spindle organization and biogenesis
Reference #:  O14965 (UniProtKB)
Alt. Names/Synonyms: AIK; ARK-1; ARK1; AURA; AURKA; Aurora A; Aurora kinase A; Aurora-related kinase 1; aurora/IPL1-like kinase; Aurora/IPL1-related kinase 1; AURORA2; Breast tumor-amplified kinase; breast-tumor-amplified kinase; BTAK; hARK1; IPL1-related kinase; MGC34538; serine/threonine kinase 6; serine/threonine protein kinase 15; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A; STK15; STK6; STK7
Gene Symbols: AURKA
Molecular weight: 45,809 Da
Basal Isoelectric point: 9.45  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AurA

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
cell cycle regulation: T288‑p, S342‑p
cytoskeletal reorganization: T288‑p, S342‑p
enzymatic activity, induced: S284‑p, T287‑p, T288‑p, S342‑p
enzymatic activity, inhibited: T287‑p
protein stabilization: S51‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S10-p RSKENCIsGPVKAtA
1 0 G11 SKENCIsGPVKAtAP
0 1 T16-p IsGPVKAtAPVGGPK
1 0 G20 VKAtAPVGGPKRVLV
0 2 S41-p QNPLPVNsGQAQRVL
4 1 S51-p AQRVLCPsNSSQRVP
0 1 S67-p QAQKLVSsHKPVQNQ
0 2 S83-p QKQLQATsVPHPVsR
1 0 S89-p TsVPHPVsRPLNNTQ
1 0 K97 RPLNNTQKsKQPLPs
0 1 S98-p PLNNTQKsKQPLPsA
0 1 S104-p KsKQPLPsAPENNPE
1 0 N109 LPsAPENNPEEELAs
1 0 A115 NNPEEELAsKQKNEE
0 1 S116-p NPEEELAsKQKNEES
1 9 Y148-p KGKFGNVyLAREKQS
0 1 Y197-p HPNILRLyGyFHDAT
0 1 Y199-p NILRLyGyFHDATRV
0 1 Y212-p RVYLILEyAPLGTVY
0 1 S226-p YRELQKLsKFDEQRT
0 1 S266-p PENLLLGsAGELKIA
0 1 S278-p KIADFGWsVHAPSsR
1 0 S283 GWsVHAPSsRRttLC
2 0 S284-p WsVHAPSsRRttLCG
5 3 T287-p HAPSsRRttLCGtLD
28 9 T288-p APSsRRttLCGtLDY
0 6 T292-p RRttLCGtLDYLPPE
3 1 S342-p QETYKRIsRVEFTFP
0 1 S369-p RLLKHNPsQRPMLRE
0 1 S391-p TANSSKPsNCQNKES
2914 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb
2995 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Biotinylated)
3079 : Phospho-Aurora A (Thr288) (C39D8) Rabbit mAb
8525 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
  mouse

 
S10 RCKENCVSRPVKTTV
R11 CKENCVSRPVKTTVP
T16 VSRPVKTTVPFGPKR
G20 VKTTVPFGPKRVLVT
S40 QNLGSASSGQAQRVL
S50 AQRVLCPSNSQRVPS
G65 QAQKLGAGQKPAPKQ
S77 PKQLPAASVPRPVSR
S83 ASVPRPVSRLNNPQK
K90 SRLNNPQKNEQPAAS
N91 RLNNPQKNEQPAASG
A95 PQKNEQPAASGNDSE
D100 QPAASGNDSEKEQAS
A106 NDSEKEQASLQKTED
S107 DSEKEQASLQKTEDT
Y139 KGKFGNVYLARERQS
Y188 HPNILRLYGYFHDAT
Y190 NILRLYGYFHDATRV
Y203 RVYLILEYAPLGTVY
S217 YRELQKLSKFDEQRT
S257 PENLLLGSNGELKIA
S269 KIADFGWSVHAPSSR
S274 GWSVHAPSSRRTtMC
S275 WSVHAPSSRRTtMCG
T278 HAPSSRRTtMCGTLD
T279-p APSSRRTtMCGTLDY
T283 RRTtMCGTLDYLPPE
S333 QETYRRISRVEFTFP
S360 RLLKHNASQRLTLAE
T383 ANSSKPPTGHTSKEP
2914 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb
2995 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Biotinylated)
8525 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
  rat

 
S10 RCKENCVSRPVKSTV
R11 CKENCVSRPVKSTVP
T16 VSRPVKSTVPFGPKR
G20 VKSTVPFGPKRVLVT
S40 QHPGSASSGQAQRVL
S50 AQRVLCPSNSQRVPP
G65 QAQKPVAGQKPVLKQ
S77 LKQLPAASGPRPASR
S83 ASGPRPASRLSNPQK
K90 SRLSNPQKSEQPQPA
S91 RLSNPQKSEQPQPAA
A97 KSEQPQPAASGNNSE
N102 QPAASGNNSEKEQTS
T108 NNSEKEQTSIQKTED
S109 NSEKEQTSIQKTEDS
Y141 KGKFGNVYLAREKQS
Y190 HPNILRLYGYFHDAT
Y192 NILRLYGYFHDATRV
Y205 RVYLILEYAPLGTVY
S219 YRELQKLSKFDEQRT
S259 PENLLLGSNGELKIA
S271 KIADFGWSVHAPSSR
S276 GWSVHAPSSRRTtLC
S277 WSVHAPSSRRTtLCG
T280 HAPSSRRTtLCGTLD
T281-p APSSRRTtLCGTLDY
T285 RRTtLCGTLDYQPPE
S335 QETYRRISRVEFTFP
S362 RLLKHNSSQRLTLAE
T385 ANSSKPPTGHNSKEA
2914 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb
2995 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Biotinylated)
8525 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
  pig

 
S10 KCKENCISGLKTTVP
G11 CKENCISGLKTTVPP
T15 CISGLKTTVPPGDGP
G19 LKTTVPPGDGPKRVP
S41 QHLPSANSGQAQRVL
S51 AQRVLCPSNSSQRLP
S67 HTQKLVSSHKPVQNL
S83 QKQSQATSGPRPVSR
S89 TSGPRPVSRPLSNTQ
Q97 RPLSNTQQSEQPQPA
S98 PLSNTQQSEQPQPAA
A104 QSEQPQPAAPGNNPE
N109 QPAAPGNNPEKEAAS
A115 NNPEKEAASKQKNEE
S116 NPEKEAASKQKNEES
Y148 KGKFGNVYLAREKQS
Y197 HPNILRLYGYFHDAT
Y199 NILRLYGYFHDATRV
Y212 RVYLILEYAPLGAVY
S226 YRELQKLSKFDEQRT
S266 PENLLLGSAGELKIA
S278 KIADFGWSVHAPssR
S283-p GWSVHAPssRRTTLC
S284-p WSVHAPssRRTTLCG
T287 HAPssRRTTLCGTLD
T288 APssRRTTLCGTLDY
T292 RRTTLCGTLDYLPPE
S342 QETYKRISRVEFTFP
S369 RLLKHNPSHRPTLKE
S391 TANSKPASSHKKEST
  frog

 
P11 AVKENHKPsNVKIFH
S12-p VKENHKPsNVKIFHP
F17 KPsNVKIFHPMtEGA
T21-p VKIFHPMtEGAKRIP
A43 QFRPPGTAVSAQRIL
S53-p AQRILGPsNVPQRVL
S70 AQKPILSSQKPTTQI
S89 ATQGHQSSKPQGPNE
N95 SSKPQGPNENRNPQQ
T103-p ENRNPQQtSHSSTPN
S104 NRNPQQtSHSSTPNV
N110 tSHSSTPNVEKKGsT
S116-p PNVEKKGsTDQGKtS
T122-p GsTDQGKtSAVPKEE
S123 sTDQGKtSAVPKEEG
Y155-p KGKFGNVyLARERES
Y204 HPNILRLYGYFHDAS
Y206 NILRLYGYFHDASRV
Y219 RVYLILDYAPGGELF
T233 FRELQKCTRFDDQRS
S273 PENLLLGSNGELKIA
S285 KIADFGWSVHAPSSR
S290 GWSVHAPSSRRttLC
S291 WSVHAPSSRRttLCG
T294-p HAPSSRRttLCGTLD
T295-p APSSRRttLCGTLDY
T299 RRttLCGTLDYLPPE
S349-p QETYRRIsKVEFQYP
N376 KLLKHNPNHRLPLKG
Q395 PWIIKNSQLKKKDEP
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