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Protein Page:
USP18 (human)

USP18 Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms. Belongs to the peptidase C19 family. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.2.-; Ubiquitin-specific protease; Protease; EC 3.4.19.-
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: nucleus; cytosol
Molecular Function: protein binding; ISG15-specific protease activity; cysteine-type endopeptidase activity; ubiquitin-specific protease activity
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; cytokine and chemokine mediated signaling pathway
Reference #:  Q9UMW8 (UniProtKB)
Alt. Names/Synonyms: 43 kDa ISG15-specific protease; hUBP43; ISG15-specific-processing protease; ISG43; ubiquitin specific peptidase 18; ubiquitin specific protease 18; Ubl carboxyl-terminal hydrolase 18; Ubl thioesterase 18; UBP18; UBP43; USP18
Gene Symbols: USP18
Molecular weight: 43,011 Da
Basal Isoelectric point: 8.05  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.



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