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USP18 (human)

Overview USP18 Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms. Belongs to the peptidase C19 family. Note: This description may include information from UniProtKB. Protein type: EC 3.4.19.-; EC 3.1.2.-; Protease; Ubiquitin-specific protease Cellular Component: cytosol; nucleus Molecular Function: ubiquitin thiolesterase activity; ubiquitin-specific protease activity Biological Process: ubiquitin-dependent protein catabolic process; cytokine and chemokine mediated signaling pathway Reference #:  Q9UMW8 (UniProtKB) Alt. Names/Synonyms: 43 kDa ISG15-specific protease; hUBP43; ISG15-specific-processing protease; ISG43; ubiquitin specific peptidase 18; ubiquitin specific protease 18; Ubl carboxyl-terminal hydrolase 18; Ubl thioesterase 18; UBP18; UBP43; USP18 Gene Symbols: USP18 Molecular weight: 43,011 Da Basal Isoelectric point: 8.05  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

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	Modification Sites and Domains

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