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AurB
a member of the AUR family of kinases. May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Expressed during S and G2/M phase and expression is upregulated in cancer cells during M phase. Localized to the midzone of central spindle in late anaphase and concentrated into the midbody in telophase and cytokinesis. Colocalizes with gamma tubulin in the mid-body. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Overexpressed in colorectal and other cancer cell lines and thought to cause aneuploidy via histone phosphorylation. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Other group; AUR family |
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Cellular Component: spindle; midbody; cytosol; nucleus; condensed nuclear chromosome, pericentric region
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Molecular Function: protein serine/threonine kinase activity; protein binding; metal ion binding; protein serine/threonine/tyrosine kinase activity; ATP binding
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Biological Process: M phase of mitotic cell cycle; spindle midzone assembly involved in mitosis; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; protein amino acid autophosphorylation; histone modification; regulation of chromosome segregation; mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; attachment of spindle microtubules to kinetochore; negative regulation of B cell apoptosis; mitotic prometaphase
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Reference #:
Q96GD4 (UniProtKB)
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| Alt. Names/Synonyms: AIK2; AIM-1; AIM1; ARK-2; ARK2; AurB; AURKB; aurkb-sv1; aurkb-sv2; Aurora B; Aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; Aurora- and IPL1-like midbody-associated protein 1; aurora-1; aurora-B; Aurora-related kinase 2; Aurora/IPL1-related kinase 2; IPL1; serine/threonine kinase 12; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase aurora-B; STK-1; STK12; STK5 |
| Gene Symbols: AURKB |
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Molecular weight: 39,311 Da
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Basal Isoelectric point: 9.36
Predict pI for various phosphorylation states
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CST Pathways:
Regulation of Microtubule Dynamics
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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