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Protein Page:
AurB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AurB a member of the AUR family of kinases. May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Expressed during S and G2/M phase and expression is upregulated in cancer cells during M phase. Localized to the midzone of central spindle in late anaphase and concentrated into the midbody in telophase and cytokinesis. Colocalizes with gamma tubulin in the mid-body. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Overexpressed in colorectal and other cancer cell lines and thought to cause aneuploidy via histone phosphorylation. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Kinase, protein; EC 2.7.11.1; Other group; AUR family
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: intercellular bridge; nucleolus; spindle; midbody; cytosol; nucleus; condensed nuclear chromosome, pericentric region; chromocenter
Molecular Function: protein serine/threonine kinase activity; protein binding; metal ion binding; protein serine/threonine/tyrosine kinase activity; histone serine kinase activity; ATP binding
Biological Process: positive regulation of cytokinesis; spindle stabilization; spindle midzone assembly involved in mitosis; spindle checkpoint; protein amino acid autophosphorylation; regulation of chromosome segregation; negative regulation of transcription from RNA polymerase II promoter; attachment of spindle microtubules to kinetochore; protein amino acid phosphorylation; negative regulation of cytokinesis; cytokinesis checkpoint; cell proliferation; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; histone modification; abscission; mitotic cell cycle; negative regulation of protein binding; negative regulation of B cell apoptosis; aging
Reference #:  Q96GD4 (UniProtKB)
Alt. Names/Synonyms: AIK2; AIM-1; AIM1; ARK-2; ARK2; AurB; AURKB; aurkb-sv1; aurkb-sv2; Aurora B; Aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; Aurora- and IPL1-like midbody-associated protein 1; aurora-1; aurora-B; Aurora-related kinase 2; Aurora/IPL1-related kinase 2; IPL1; serine/threonine kinase 12; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase aurora-B; STK-1; STK12; STK5
Gene Symbols: AURKB
Molecular weight: 39,311 Da
Basal Isoelectric point: 9.36  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AurB

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
cell cycle regulation: S331‑p
cytoskeletal reorganization: T232‑p
enzymatic activity, induced: T232‑p, S331‑p
intracellular localization: T232‑p, S331‑p
molecular association, regulation: S331‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 6 S7-p _MAQKENsyPWPyGR
0 1 Y8-p MAQKENsyPWPyGRQ
0 1 Y12-p ENsyPWPyGRQtAPS
0 1 T16-p PWPyGRQtAPSGLST
0 4 A17 WPyGRQtAPSGLSTL
0 1 P25 PSGLSTLPQRVLRKE
0 4 T35-p VLRKEPVtPSALVLM
0 3 S45-p ALVLMSRsNVQPTAA
0 6 K56-ub PTAAPGQkVMENssG
0 4 S61-p GQkVMENssGtPDIL
0 2 S62-p QkVMENssGtPDILT
0 7 T64-p VMENssGtPDILTRH
0 1 - gap
0 2 T73-p DILTRHFtIDDFEIG
1 0 K85-sm EIGRPLGkGkFGNVy
0 1 K85-ub EIGRPLGkGkFGNVy
1 0 K87-sm GRPLGkGkFGNVyLA
0 9 Y92-p kGkFGNVyLAREKKS
0 1 K115-ub LFKSQIEkEGVEHQL
0 2 K168-ub ELYKELQkSCTFDEQ
1 0 K202-sm KVIHRDIkPENLLLG
0 1 K202-ub KVIHRDIkPENLLLG
0 4 K211-ub ENLLLGLkGELkIAD
0 2 K215-ub LGLkGELkIADFGWS
0 8 S227-p GWSVHAPsLRRKtMC
18 96 T232-p APsLRRKtMCGtLDY
0 20 T236-p RRKtMCGtLDYLPPE
0 1 K287-ub ETYRRIVkVDLkFPA
0 1 K291-ub RIVkVDLkFPASVPM
0 1 A294 kVDLkFPASVPMGAQ
0 2 K306-ub GAQDLISkLLRHNPs
0 2 S313-p kLLRHNPsERLPLAQ
3 0 S331-p HPWVRANsRRVLPPS
2914 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb
2995 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Biotinylated)
8525 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
13464 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb  (Alexa Fluor(R) 555 Conjugate)
  mouse

 
A7 _MAQKENAYPWPYGS
Y8 MAQKENAYPWPYGSK
Y12 ENAYPWPYGSKTsQS
T16 PWPYGSKTsQSGLNT
S17-p WPYGSKTsQSGLNTL
S25-p QSGLNTLsQRVLRKE
T35 VLRKEPATTSALALV
F45 ALALVNRFNSQSTAA
K56 STAAPGQKLAENKSQ
- gap
- gap
- gap
S71-p GSTASQGsQNKQPFT
T78 sQNKQPFTIDNFEIG
K90 EIGRPLGKGKFGNVY
K90 EIGRPLGKGKFGNVY
K92 GRPLGKGKFGNVYLA
Y97 KGKFGNVYLAREKKS
K120 LFKSQIEKEGVEHQL
K173 ELYKELQKSRTFDEQ
K207 KVIHRDIKPENLLLG
K207 KVIHRDIKPENLLLG
Q216 ENLLLGLQGELKIAD
K220 LGLQGELKIADFGWS
S232-p GWSVHAPsLRRKtMC
T237-p APsLRRKtMCGtLDY
T241-p RRKtMCGtLDYLPPE
K292 ETYRRIVKVDLKFPs
K296 RIVKVDLKFPsSVPS
S299-p KVDLKFPsSVPSGAQ
K311 GAQDLISKLLKHNPW
W318 KLLKHNPWQRLPLAE
S336 HPWVRANSRRVLPPS
2914 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb
2995 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Biotinylated)
8525 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
13464 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb  (Alexa Fluor(R) 555 Conjugate)
  rat

 
V7 _MAQKENVYPWPYGS
Y8 MAQKENVYPWPYGSK
Y12 ENVYPWPYGSKTSQS
T16 PWPYGSKTSQSGLNT
S17 WPYGSKTSQSGLNTL
P25 QSGLNTLPQRVLRKE
V35 VLRKEPAVTPAQALM
S45 AQALMNRSNSQSTAV
K56 STAVPGQKLTENKGA
- gap
- gap
- gap
S69 GATALQGSQSRQPFT
T76 SQSRQPFTIDNFEIG
K88 EIGRPLGKGKFGNVY
K88 EIGRPLGKGKFGNVY
K90 GRPLGKGKFGNVYLA
Y95 KGKFGNVYLAREKKS
K118 LFKSQIEKEGVEHQL
K171 ELYKELQKSGTFDEQ
K205 KVIHRDIKPENLLLG
K205 KVIHRDIKPENLLLG
Q214 ENLLLGLQGELKIAD
K218 LGLQGELKIADFGWS
S230 GWSVHAPSLRRKtMC
T235-p APSLRRKtMCGTLDY
T239 RRKtMCGTLDYLPPE
K290 ETYRRIVKVDLKFPS
K294 RIVKVDLKFPSSMPL
S297 KVDLKFPSSMPLGAK
K309 GAKDLISKLLKHNPS
S316 KLLKHNPSQRLPLEQ
S334 HPWVRANSRRVLPPS
2914 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb
2995 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Biotinylated)
8525 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
13464 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb  (Alexa Fluor(R) 555 Conjugate)
  pig

 
T7 _MAQKENTYPWPYGR
Y8 MAQKENTYPWPYGRQ
Y12 ENTYPWPYGRQTAQS
T16 PWPYGRQTAQSGLNI
A17 WPYGRQTAQSGLNIL
P25 QSGLNILPQRVLRKE
T35 VLRKEAVTPSALVLM
S45 ALVLMSRSNTQPTAA
K56 PTAAPGQKVVENSSG
S61 GQKVVENSSGTPNFS
S62 QKVVENSSGTPNFST
T64 VVENSSGTPNFSTRS
- gap
T73 NFSTRSFTIDDFEIG
K85 EIGRPLGKGKFGNVY
K85 EIGRPLGKGKFGNVY
K87 GRPLGKGKFGNVYLA
Y92 KGKFGNVYLAREKKS
K115 LFKSQIEKEGVEHQL
K168 ELYKELQKCRTFDEQ
K202 KVIHRDIKPENLLLG
K202 KVIHRDIKPENLLLG
Q211 ENLLLGLQGELKIAD
K215 LGLQGELKIADFGWS
S227 GWSVHAPSLRRKtMC
T232-p APSLRRKtMCGTLDY
T236 RRKtMCGTLDYLPPE
K287 ETYRRIGKVDLKFPP
K291 RIGKVDLKFPPSVPA
P294 KVDLKFPPSVPAGAQ
K306 GAQDLISKLLKHNPS
S313 KLLKHNPSDRLPLAQ
S331 HPWVRAHSRRVLPPS
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