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Protein Page:
AurC (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AurC a member of the AUR family of kinases. May play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. Localized to centrosome from anaphase to cytokinesis. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; AUR family
Cellular Component: cytoplasm; condensed chromosome; spindle; midbody; spindle midzone; nucleus; chromosome, pericentric region
Molecular Function: protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ATP binding; protein kinase activity
Biological Process: positive regulation of cytokinesis; meiosis; spindle midzone assembly involved in mitosis; histone modification; cytokinesis; attachment of spindle microtubules to kinetochore; protein amino acid phosphorylation
Reference #:  Q9UQB9 (UniProtKB)
Alt. Names/Synonyms: AIE2; AIK3; ARK-3; ARK3; AurC; AURKC; Aurora C; Aurora kinase C; aurora-C; Aurora-related kinase 3; Aurora/IPL1-related kinase 3; Aurora/IPL1/Eg2 protein 2; serine/threonine kinase 13 (aurora/IPL1-like); Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C; STK13
Gene Symbols: AURKC
Molecular weight: 35,591 Da
Basal Isoelectric point: 8.96  Predict pI for various phosphorylation states
Select Structure to View Below

AurC

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S32-p QTAQQPSsPAMRRLT
0 1 S77-p ALKVLFKsQIEKEGL
0 1 K197-ac HTPSLRRktMCGtLD
4 85 T198-p TPSLRRktMCGtLDY
2 19 T202-p RRktMCGtLDYLPPE
0 1 S271-p LGARDLIsRLLRYQP
2914 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb
2995 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Biotinylated)
8525 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
13464 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb  (Alexa Fluor(R) 555 Conjugate)
  AurC iso2  
- gap
S43 ALKVLFKSQIEKEGL
K163 HTPSLRRKtMCGTLD
T164-p TPSLRRKtMCGTLDY
T168 RRKtMCGTLDYLPPE
S237 LGARDLISRLLRYQP
  mouse

 
- gap
S50 ALKVLFKSEIEKEGL
K170 HTPSLRRKtMCGtLD
T171-p TPSLRRKtMCGtLDY
T175-p RRKtMCGtLDYLPPE
S244 AGAQDLISKLLRYHP
2914 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb
2995 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Biotinylated)
8525 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
13464 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb  (Alexa Fluor(R) 555 Conjugate)
  rat

 
- gap
S50 ALKVLFKSEIGKEGL
K170 HTPSLRRKTMCGTLD
T171 TPSLRRKTMCGTLDY
T175 RRKTMCGTLDYLPPE
S244 AGAQDLISKLLRHHP
2914 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb
2995 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Biotinylated)
8525 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
13464 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb  (Alexa Fluor(R) 555 Conjugate)
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