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Protein Page:
AurC (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
AurC a member of the AUR family of kinases. May play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. Localized to centrosome from anaphase to cytokinesis. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Other; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Other group; AUR family
Cellular Component: cytoplasm; condensed chromosome; spindle; midbody; spindle midzone; nucleus; chromosome, pericentric region
Molecular Function: protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ATP binding; protein kinase activity
Biological Process: positive regulation of cytokinesis; meiosis; spindle midzone assembly involved in mitosis; histone modification; cytokinesis; attachment of spindle microtubules to kinetochore; protein amino acid phosphorylation
Reference #:  Q9UQB9 (UniProtKB)
Alt. Names/Synonyms: AIE2; AIK3; ARK-3; ARK3; AurC; AURKC; Aurora C; Aurora kinase C; aurora-C; Aurora-related kinase 3; Aurora/IPL1-related kinase 3; Aurora/IPL1/Eg2 protein 2; serine/threonine kinase 13 (aurora/IPL1-like); Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C; STK13
Gene Symbols: AURKC
Molecular weight: 35,591 Da
Basal Isoelectric point: 8.96  Predict pI for various phosphorylation states
Select Structure to View Below

AurC

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K197-a HTPSLRRktMCGtLD
4 69 T198-p TPSLRRktMCGtLDY
2 14 T202-p RRktMCGtLDYLPPE
2914 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb
2995 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Biotinylated)
8525 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
  AurC iso2  
K163 HTPSLRRKtMCGTLD
T164-p TPSLRRKtMCGTLDY
T168 RRKtMCGTLDYLPPE
  mouse

 
K170 HTPSLRRKtMCGtLD
T171-p TPSLRRKtMCGtLDY
T175-p RRKtMCGtLDYLPPE
2914 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb
2995 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Biotinylated)
8525 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
  rat

 
K170 HTPSLRRKTMCGTLD
T171 TPSLRRKTMCGTLDY
T175 RRKTMCGTLDYLPPE
2914 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb
2995 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Biotinylated)
8525 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
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