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Protein Page:
BRAT1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
BRAT1 Required for activation of ATM following ionizing radiation. May act by regulating dephosphorylation of ATM. Defects in BRAT1 are the cause of rigidity and multifocal seizure syndrome, lethal neonatal (RMFSL). A lethal, neonatal, neurologic disorder characterized by episodic jerking that is apparent in utero, lack of psychomotor development, axial and limb rigidity, frequent multifocal seizures, and dysautonomia. At birth, affected individuals have small heads, overlapping cranial sutures, small or absent fontanels, and depressed frontal bones. Infants show poorly responsive focal jerks of the tongue, face and arms in a nearly continuous sequence throughout life. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: nucleus
Molecular Function: protein binding
Biological Process: response to ionizing radiation
Reference #:  Q6PJG6 (UniProtKB)
Alt. Names/Synonyms: BRAT1; BRCA1-associated ATM activator 1; C7orf27; CG027; chromosome 7 open reading frame 27; HEAT repeat-containing protein C7orf27; MGC22916
Gene Symbols: BRAT1
Molecular weight: 88,119 Da
Basal Isoelectric point: 5.11  Predict pI for various phosphorylation states
Select Structure to View Below

BRAT1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S121-p WAVPTVRsGWIQGLR
0 1 K483-u RWLLSSPkTPGCSDL
0 3 K507-u ELFPVLQkRLCHPCW
0 2 T581-p SQGLHAPtsPEHAEA
0 8 S582-p QGLHAPtsPEHAEAR
0 2 Y675-p PPRTHCPyAVALPEV
0 2 P684 VALPEVAPAQPLTEA
0 5 K729-u LLLFLRDkIASYSSL
0 15 S742-p SLREARGsPNtASAE
0 1 T745-p EARGsPNtASAEATL
0 1 S747 RGsPNtASAEATLPR
0 1 - gap
  BRAT1 iso4  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K92-m1 LVTVGRLkCSLRELF
  mouse

 
S121 WSIPSVRSGWIQGLC
K483 RWLQNPHKTPSSSDL
K507 ELFPILQKRLCSPCW
A582 QGLQAAPASPENSQA
S583 GLQAAPASPENSQAQ
Y676 QPSLHCPYTVGLPRA
S685-p VGLPRASsPRPHPEF
K730 LLLFLRDKTVPCSSP
S743-p SPREAGDsPNsAsVE
S746-p EAGDsPNsAsVEAAL
S748-p GDsPNsAsVEAALQR
- gap
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