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Protein Page:
SERCA2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SERCA2 an intracellular pump located in the sarcoplasmic or endoplasmic reticula of muscle cells. Possesses a Ca(2+)-ATPase activity. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Transporter; Cell adhesion; EC 3.6.3.8; Hydrolase; Endoplasmic reticulum
Cellular Component: endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; protein complex; membrane; sarcoplasmic reticulum; intracellular membrane-bound organelle; integral to plasma membrane
Molecular Function: protein C-terminus binding; calcium-transporting ATPase activity; lutropin-choriogonadotropic hormone receptor binding; calcium ion binding; ATP binding
Biological Process: cellular calcium ion homeostasis; ER-nuclear signaling pathway; response to peptide hormone stimulus; epidermis development; negative regulation of heart contraction; transport; ATP biosynthetic process; cell adhesion; blood coagulation; transmembrane transport; regulation of the force of heart contraction
Reference #:  P16615 (UniProtKB)
Alt. Names/Synonyms: AT2A2; ATP2A2; ATP2B; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; ATPase, Ca++ transporting, slow twitch 2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; cardiac Ca2+ ATPase; DAR; DD; DKFZp686P0211; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; FLJ20293; FLJ38063; MGC45367; Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2; SR Ca(2+)-ATPase 2
Gene Symbols: ATP2A2
Molecular weight: 114,757 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SERCA2
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 2 K30-u GLSLEQVkkLkERWG
0 1 K31-a LSLEQVkkLkERWGs
0 1 K31-u LSLEQVkkLkERWGs
0 1 K33-a LEQVkkLkERWGsNE
1 3 S38-p kLkERWGsNELPAEE
0 3 K120-u ENAIEALkEyEPEMG
0 1 Y122-p AIEALkEyEPEMGkV
0 2 K128-u EyEPEMGkVYRQDRK
0 1 S136-p VYRQDRKsVQRIKAK
0 2 K143 sVQRIKAKDIVPGDI
0 1 K158 VEIAVGDKVPADIRL
0 2 K169-u DIRLTSIkSTTLRVD
0 1 S186-p ILTGESVsVIkHtDP
0 2 K189-u GESVsVIkHtDPVPD
0 1 T191-p SVsVIkHtDPVPDPR
0 1 K218-a GTNIAAGkAMGVVVA
0 2 T226-p AMGVVVAtGVNtEIG
0 1 T230-p VVAtGVNtEIGKIRD
0 2 K252-u ERTPLQQkLDEFGEQ
0 2 K328-u LGTRRMAkkNAIVRS
0 1 K329-u GTRRMAkkNAIVRSL
0 1 S378 RVEGDTCSLNEFTIT
0 2 Y407 KPVNCHQYDGLVELA
0 2 Y427-p CNDSALDyNEAkGVY
0 1 K431-u ALDyNEAkGVYEkVG
0 1 K436-u EAkGVYEkVGEATET
0 8 T441 YEkVGEATETALTCL
0 2 K451-u ALTCLVEkMNVFDTE
0 16 K460-u NVFDTELkGLSkIER
0 1 K464-a TELkGLSkIERANAC
0 1 K464-u TELkGLSkIERANAC
0 1 K476 NACNSVIKQLMkKEF
1 0 K480-s SVIKQLMkKEFtLEF
0 4 T484-p QLMkKEFtLEFSRDR
0 1 K492 LEFSRDRKSMsVyCt
0 1 S495-p SRDRKSMsVyCtPNk
0 114 Y497-p DRKSMsVyCtPNkPs
0 6 T499-p KSMsVyCtPNkPsRT
0 2 K502-u sVyCtPNkPsRTSMS
0 3 S504-p yCtPNkPsRTSMSKM
0 1 K510 PsRTSMSKMFVkGAP
0 3 K514-u SMSKMFVkGAPEGVI
0 1 S531 CTHIRVGSTkVPMTs
0 2 K533-u HIRVGSTkVPMTsGV
0 1 T537 GSTkVPMTsGVkQKI
0 2 S538-p STkVPMTsGVkQKIM
0 4 K541-u VPMTsGVkQKIMsVI
0 1 K543 MTsGVkQKIMsVIRE
0 2 S546-p GVkQKIMsVIREWGs
0 3 S553-p sVIREWGsGsDtLRC
0 4 S555-p IREWGsGsDtLRCLA
0 1 T557-p EWGsGsDtLRCLALA
0 1 R571 ATHDNPLRREEMHLE
1 0 K585-s EDSANFIkYETNLTF
0 8 K611-u IEVASSVkLCRQAGI
0 5 K628-u IMITGDNkGTAVAIC
0 1 T648-p FGQDEDVtskAFTGR
0 2 S649-p GQDEDVtskAFTGRE
0 40 K650-u QDEDVtskAFTGREF
0 6 N661 GREFDELNPsAQRDA
0 32 S663-p EFDELNPsAQRDACL
0 1 K685-u VEPSHKSkIVEFLQS
0 2 K711-u VNDAPALkkAEIGIA
0 2 K712-u NDAPALkkAEIGIAM
0 1 S721-p EIGIAMGsGtAVAKT
0 1 T723-p GIAMGsGtAVAKTAs
0 1 S730-p tAVAKTAsEMVLADD
0 4 K757-u RAIYNNMkQFIRYLI
0 1 Y836-p SGWLFFRyLAIGCYV
0 25 Y867-p GGPRVSFyQLSHFLQ
0 1 S973-p WLMVLKIsLPVILMD
0 1 Y990 LKFVARNYLEPGkEC
0 33 K995-u RNYLEPGkECVQPAT
  mouse

 
K30 GLSLEQVKKLKERWG
K31 LSLEQVKKLKERWGs
K31 LSLEQVKKLKERWGs
K33 LEQVKKLKERWGsNE
S38-p KLKERWGsNELPAEE
K120-u ENAIEALkEYEPEMG
Y122 AIEALkEYEPEMGkV
K128-u EYEPEMGkVYRQDRK
S136-p VYRQDRKsVQRIKAk
K143-u sVQRIKAkDIVPGDI
K158-u VEIAVGDkVPADIRL
K169-u DIRLTSIkSTTLRVD
S186-p ILTGESVsVIkHTDP
K189-u GESVsVIkHTDPVPD
T191 SVsVIkHTDPVPDPR
K218 GTNIAAGKAMGVVVA
T226 AMGVVVATGVNTEIG
T230 VVATGVNTEIGKIRD
K252 ERTPLQQKLDEFGEQ
K328-u LGTRRMAkKNAIVRS
K329 GTRRMAkKNAIVRSL
S378-p KVEGDTCsLNEFSIT
Y407 KPVKCHQYDGLVELA
Y427-p CNDSALDyNEAKGVY
K431 ALDyNEAKGVYEKVG
K436 EAKGVYEKVGEAtET
T441-p YEKVGEAtETALTCL
K451 ALTCLVEKMNVFDTE
K460-u NVFDTELkGLSKIER
K464 TELkGLSKIERANAC
K464 TELkGLSKIERANAC
K476-u NACNSVIkQLMKKEF
K480 SVIkQLMKKEFtLEF
T484-p QLMKKEFtLEFSRDR
K492-u LEFSRDRkSMSVyCt
S495 SRDRkSMSVyCtPNk
Y497-p DRkSMSVyCtPNkPs
T499-p kSMSVyCtPNkPsRT
K502-u SVyCtPNkPsRTSMS
S504-p yCtPNkPsRTSMSkM
K510-u PsRTSMSkMFVkGAP
K514-u SMSkMFVkGAPEGVI
S531-p CTHIRVGsTKVPMtP
K533 HIRVGsTKVPMtPGV
T537-p GsTKVPMtPGVkQkI
P538 sTKVPMtPGVkQkIM
K541-u VPMtPGVkQkIMSVI
K543-u MtPGVkQkIMSVIRE
S546 GVkQkIMSVIREWGs
S553-p SVIREWGsGsDTLRC
S555-p IREWGsGsDTLRCLA
T557 EWGsGsDTLRCLALA
K571-u ATHDNPLkREEMHLE
K585 EDSANFIKYETNLTF
K611-u IEVASSVkLCRQAGI
K628-u IMITGDNkGTAVAIC
T648-p FGQDEDVtskAFTGR
S649-p GQDEDVtskAFTGRE
K650-u QDEDVtskAFTGREF
S661-p GREFDELsPsAQRDA
S663-p EFDELsPsAQRDACL
K685 VEPSHKSKIVEFLQS
K711 VNDAPALKkSEIGIA
K712-u NDAPALKkSEIGIAM
S721 EIGIAMGSGtAVAKT
T723-p GIAMGSGtAVAKTAS
S730 tAVAKTASEMVLADD
K757-u RAIYNNMkQFIRYLI
Y836 SGWLFFRYLAIGCYV
Y867 GGPRVSFYQLSHFLQ
S973 WLMVLKISLPVILMD
Y990-p LKFVARNyLEQPGkE
K996-u NyLEQPGkECVQPAT
  rat

 
K30 GLSLEQVKKLKERWG
K31 LSLEQVKKLKERWGs
K31 LSLEQVKKLKERWGs
K33 LEQVKKLKERWGsNE
S38-p KLKERWGsNELPAEE
K120 ENAIEALKEYEPEMG
Y122 AIEALKEYEPEMGKV
K128 EYEPEMGKVYRQDRK
S136 VYRQDRKSVQRIKAK
K143 SVQRIKAKDIVPGDI
K158 VEIAVGDKVPADIRL
K169 DIRLTSIKSTTLRVD
S186 ILTGESVSVIKHTDP
K189 GESVSVIKHTDPVPD
T191 SVSVIKHTDPVPDPR
K218 GTNIAAGKAMGVVVA
T226 AMGVVVATGVNTEIG
T230 VVATGVNTEIGKIRD
K252 ERTPLQQKLDEFGEQ
K328 LGTRRMAKKNAIVRS
K329 GTRRMAKKNAIVRSL
S378 KVEGDTCSLNEFTIT
Y407-p KPVKCHQyDGLVELA
Y427 CNDSALDYNEAKGVY
K431 ALDYNEAKGVYEKVG
K436 EAKGVYEKVGEATET
T441 YEKVGEATETALTCL
K451 ALTCLVEKMNVFDTE
K460 NVFDTELKGLSKIER
K464 TELKGLSKIERANAC
K464 TELKGLSKIERANAC
K476 NACNSVIKQLMKKEF
K480 SVIKQLMKKEFTLEF
T484 QLMKKEFTLEFSRDR
K492 LEFSRDRKSMSVyCT
S495 SRDRKSMSVyCTPNK
Y497-p DRKSMSVyCTPNKPS
T499 KSMSVyCTPNKPSRT
K502 SVyCTPNKPSRTSMS
S504 yCTPNKPSRTSMSKM
K510 PSRTSMSKMFVKGAP
K514 SMSKMFVKGAPEGVI
S531 CTHIRVGSTKVPMTP
K533 HIRVGSTKVPMTPGV
T537 GSTKVPMTPGVKQKI
P538 STKVPMTPGVKQKIM
K541 VPMTPGVKQKIMSVI
K543 MTPGVKQKIMSVIRE
S546 GVKQKIMSVIREWGS
S553 SVIREWGSGSDTLRC
S555 IREWGSGSDTLRCLA
T557 EWGSGSDTLRCLALA
R571 ATHDNPLRREEMHLE
K585 EDSANFIKYETNLTF
K611 IEVASSVKLCRQAGI
K628 IMITGDNKGTAVAIC
T648 FGQDEDVTSKAFTGR
S649 GQDEDVTSKAFTGRE
K650 QDEDVTSKAFTGREF
S661 GREFDELSPSAQRDA
S663 EFDELSPSAQRDACL
K685 VEPSHKSKIVEFLQS
K711 VNDAPALKKSEIGIA
K712 NDAPALKKSEIGIAM
S721 EIGIAMGSGTAVAKT
T723 GIAMGSGTAVAKTAS
S730 TAVAKTASEMVLADD
K757 RAIYNNMKQFIRYLI
Y836 SGWLFFRYLAIGCYV
Y867-p GGPRVSFyQLSHFLQ
S973 WLMVLKISLPVILMD
Y990 LKFVARNYLEPGKEC
K995 RNYLEPGKECAQPAT
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