The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS). EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral
Cellular Component: asymmetric synapse; postsynaptic membrane; integral to plasma membrane; basolateral plasma membrane; dendrite; plasma membrane; nerve terminal; cell junction
Molecular Function: drug binding; receptor activity; acetylcholine binding; phosphoinositide phospholipase C activity; G-protein coupled acetylcholine receptor activity
Biological Process: cell proliferation; nervous system development; G-protein coupled receptor protein signaling pathway; smooth muscle contraction; regulation of vascular smooth muscle contraction; digestion; energy reserve metabolic process; protein modification process; positive regulation of smooth muscle contraction; signal transduction; regulation of insulin secretion
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.