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mAChR M3
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS). EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily. Note: This description may include information from UniProtKB.
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| Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral |
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Cellular Component: asymmetric synapse; postsynaptic membrane; integral to plasma membrane; basolateral plasma membrane; dendrite; plasma membrane; nerve terminal; cell junction
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Molecular Function: drug binding; receptor activity; acetylcholine binding; phosphoinositide phospholipase C activity; G-protein coupled acetylcholine receptor activity
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Biological Process: cell proliferation; nervous system development; G-protein coupled receptor protein signaling pathway; smooth muscle contraction; regulation of vascular smooth muscle contraction; digestion; energy reserve metabolic process; protein modification process; positive regulation of smooth muscle contraction; signal transduction; regulation of insulin secretion
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Reference #:
P20309 (UniProtKB)
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| Alt. Names/Synonyms: ACM3; cholinergic receptor, muscarinic 3; CHRM3; HM3; m3 muscarinic receptor; Muscarinic acetylcholine receptor M3 |
| Gene Symbols: CHRM3 |
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Molecular weight: 66,128 Da
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Basal Isoelectric point: 9.33
Predict pI for various phosphorylation states
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CST Pathways:
Alzheimer's Disease
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