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Protein Page:
CYP2B6 (rat)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CYP2B6 cytochrome P450, subfamily IIB. Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Phosphorylation is accompanied by a decrease in enzyme activity. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.14.1; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Lipid Metabolism - arachidonic acid; Cofactor and Vitamin Metabolism - retinol; Xenobiotic Metabolism - metabolism by cytochrome P450; Oxidoreductase
Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle
Molecular Function: iron ion binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; arachidonic acid epoxygenase activity
Biological Process: epoxygenase P450 pathway
Reference #:  P00176 (UniProtKB)
Alt. Names/Synonyms: CP2B1; Cyp2b-1; Cyp2b1; CYP2B1; Cyp2b12; CYPIIB1; CYPIIB12; cytochrome P-450b type b; Cytochrome P450 2B1; cytochrome P450 2B12; cytochrome P450, family 2, subfamily b, polypeptide 12; Cytochrome P450-B; Cytochrome P450-LM2; Cytochrome P450-PB1; Cytochrome P450-PB2; Cytochrome P450b
Gene Symbols: Cyp2b1
Molecular weight: 55,934 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Select Structure to View Below

CYP2B6

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, inhibited: S128‑p
intracellular localization: S128‑p
protein conformation: S128‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       rat

 
4 0 S128-p WKALRRFsLATMRDF
0 1 K433-ac FMPFSTGkRICLGEG
  human

 
S128 WKVLRRFSVTTMRDF
K433-ac FIPFSLGkRICLGEG
  mouse

 
S128-p WKTLRRFsLATMRDF
K442 FDQKSVGKRICLGES
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