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CYP2B6
cytochrome P450, subfamily IIB. Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Phosphorylation is accompanied by a decrease in enzyme activity. Note: This description may include information from UniProtKB.
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| Protein type: Lipid Metabolism - arachidonic acid; EC 1.14.14.1; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Oxidoreductase; Cofactor and Vitamin Metabolism - retinol; Xenobiotic Metabolism - metabolism by cytochrome P450 |
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Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle
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Molecular Function: electron carrier activity; iron ion binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; arachidonic acid epoxygenase activity
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Biological Process: epoxygenase P450 pathway
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Reference #:
P00176 (UniProtKB)
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| Alt. Names/Synonyms: CP2B1; Cyp2b-1; Cyp2b1; CYP2B1; Cyp2b12; CYPIIB1; CYPIIB12; cytochrome P-450b type b; Cytochrome P450 2B1; cytochrome P450 2B12; cytochrome P450, family 2, subfamily b, polypeptide 12; Cytochrome P450-B; Cytochrome P450-LM2; Cytochrome P450-PB1; Cytochrome P450-PB2; Cytochrome P450b |
| Gene Symbols: Cyp2b1 |
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Molecular weight: 55,934 Da
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Basal Isoelectric point: 7
Predict pI for various phosphorylation states
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