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Protein Page:
CYP2B6 (rat)

CYP2B6 cytochrome P450, subfamily IIB. Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Phosphorylation is accompanied by a decrease in enzyme activity. Note: This description may include information from UniProtKB.
Protein type: Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Lipid Metabolism - arachidonic acid; Oxidoreductase; Cofactor and Vitamin Metabolism - retinol; EC
Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle
Molecular Function: iron ion binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; arachidonic acid epoxygenase activity
Biological Process: epoxygenase P450 pathway
Reference #:  P00176 (UniProtKB)
Alt. Names/Synonyms: CP2B1; Cyp2b-1; Cyp2b1; CYP2B1; Cyp2b12; CYPIIB1; CYPIIB12; cytochrome P-450b type b; Cytochrome P450 2B1; cytochrome P450 2B12; cytochrome P450, family 2, subfamily b, polypeptide 12; Cytochrome P450-B; Cytochrome P450-LM2; Cytochrome P450-PB1; Cytochrome P450-PB2; Cytochrome P450b
Gene Symbols: Cyp2b1
Molecular weight: 55,934 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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Sites Implicated In
enzymatic activity, inhibited: S128‑p
intracellular localization: S128‑p
protein conformation: S128‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

Show Multiple Sequence Alignment


SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.




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