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Protein Page:
Lamin B1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Lamin B1 nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Nuclear lamins are cleaved by caspases during apoptosis. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein
Cellular Component: nucleoplasm; nuclear membrane; membrane; lamin filament; nuclear inner membrane; nuclear envelope
Molecular Function: phospholipase binding; structural molecule activity
Biological Process: apoptosis; cell structure disassembly during apoptosis
Reference #:  P20700 (UniProtKB)
Alt. Names/Synonyms: ADLD; lamin B1; Lamin-B1; LMN; LMN2; LMNB; LMNB1; MGC111419
Gene Symbols: LMNB1
Molecular weight: 66,408 Da
Basal Isoelectric point: 5.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Lamin B1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 T3-p _____MAtAtPVPPR
0 5 T5-p ___MAtAtPVPPRMG
0 3 S13-p PVPPRMGsrAGGPtt
0 2 R14-m1 VPPRMGsrAGGPttP
0 18 G16 PRMGsrAGGPttPLs
0 6 T19-p GsrAGGPttPLsPtR
0 151 T20-p srAGGPttPLsPtRL
2 122 S23-p GGPttPLsPtRLsRL
0 23 T25-p PttPLsPtRLsRLQE
0 3 S28-p PLsPtRLsRLQEkEE
0 2 K33-ac RLsRLQEkEELRELN
0 4 Y46-p LNDRLAVyIDkVRSL
0 8 K49-ub RLAVyIDkVRSLETE
0 1 S58-p RSLETENsALQLQVT
0 1 K79-ac GRELTGLkALYETEL
0 4 K79-ub GRELTGLkALYETEL
0 1 K102-ac DTARERAkLQIELGk
0 2 K102-ub DTARERAkLQIELGk
0 3 K109 kLQIELGKCkAEHDQ
0 6 K109-ub kLQIELGkCkAEHDQ
0 2 K111-ac QIELGkCkAEHDQLL
0 20 K111-ub QIELGkCkAEHDQLL
0 1 K123-ac QLLLNYAkKESDLNG
0 1 K123-ub QLLLNYAkKESDLNG
0 1 K123-sc QLLLNYAkKESDLNG
0 1 K124 LLLNYAkKESDLNGA
0 1 K134-ac DLNGAQIkLREyEAA
0 13 K134-ub DLNGAQIkLREyEAA
0 1 Y138-p AQIkLREyEAALNSk
0 2 K145-ub yEAALNSkDAALATA
0 1 K156-ac LATALGDkksLEGDL
0 2 K156-ub LATALGDkksLEGDL
0 2 K157-ac ATALGDkksLEGDLE
0 10 K157-ub ATALGDkksLEGDLE
0 4 S158-p TALGDkksLEGDLED
0 1 K167 EGDLEDLKDQIAQLE
0 3 K167-ub EGDLEDLkDQIAQLE
0 1 K181-ac EASLAAAkkQLADET
0 4 K181-ub EASLAAAkkQLADET
0 1 K181-sc EASLAAAkkQLADET
0 85 K182-ub ASLAAAkkQLADETL
0 1 K191 LADETLLKVDLENRC
0 5 S200-p DLENRCQsLTEDLEF
0 4 K209-ub TEDLEFRksMyEEEI
0 4 S210-p EDLEFRksMyEEEIN
0 1 Y212-p LEFRksMyEEEINET
0 8 S232-p TRLVEVDsGRQIEYE
0 12 K241-ub RQIEYEYkLAQALHE
0 1 K261 DAQVRLYKEELEQty
0 6 K261-ub DAQVRLYkEELEQty
0 1 K261-sc DAQVRLYkEELEQty
0 1 T267-p YkEELEQtyHAkLEN
0 6 Y268-p kEELEQtyHAkLENA
0 23 K271-ac LEQtyHAkLENARLs
0 24 K271-ub LEQtyHAkLENARLs
0 2 S278-p kLENARLsSEMNtst
0 2 T283-p RLsSEMNtstVNsAR
0 19 S284-p LsSEMNtstVNsARE
0 2 T285-p sSEMNtstVNsAREE
0 3 S288-p MNtstVNsAREELME
0 29 S302-p ESRMRIEsLssQLSN
0 2 S304-p RMRIEsLssQLSNLQ
0 1 S305-p MRIEsLssQLSNLQk
0 1 S308 EsLssQLSNLQkESR
0 1 K312-ac sQLSNLQkESRACLE
0 79 K312-ub sQLSNLQkESRACLE
0 1 K330 ELEDLLAKEKDNSRR
0 6 K330-ub ELEDLLAkEKDNSRR
0 1 T340-p DNSRRMLtDkEREMA
0 1 K342-ub SRRMLtDkEREMAEI
0 1 N358 DQMQQQLNDyEQLLD
0 1 Y360-p MQQQLNDyEQLLDVK
0 6 S375-p LALDMEIsAYRkLLE
0 2 K379-ac MEIsAYRkLLEGEEE
0 55 K379-ub MEIsAYRkLLEGEEE
0 62 K389-ub EGEEERLkLsPsPss
0 38 S391-p EEERLkLsPsPssRV
1 31 S393-p ERLkLsPsPssRVtV
3 9 S395-p LkLsPsPssRVtVsR
0 6 S396-p kLsPsPssRVtVsRA
0 10 T399-p PsPssRVtVsRAsss
0 31 S401-p PssRVtVsRAsssRs
0 112 S404-p RVtVsRAsssRsVRt
3 98 S405-p VtVsRAsssRsVRtt
0 37 S406-p tVsRAsssRsVRttR
0 74 S408-p sRAsssRsVRttRGK
0 2 T411-p sssRsVRttRGKRKR
0 3 T412-p ssRsVRttRGKRKRV
0 1 S479-p IRKIGDTsVsYkYTS
0 1 S481-p KIGDTsVsYkYTSRY
0 4 K483-ac GDTsVsYkYTSRYVL
0 1 K483-ub GDTsVsYkYTSRYVL
0 1 K528-ub WGTGEDVkVILkNsQ
0 10 K532-ub EDVkVILkNsQGEEV
0 9 S534-p VkVILkNsQGEEVAQ
0 1 S543 GEEVAQRSTVFkTTI
0 16 K547-ub AQRSTVFkTTIPEEE
0 60 T575-p ELFHQQGtPRASNRS
  mouse

 
T3-p _____MAtAtPVQQQ
T5-p ___MAtAtPVQQQRA
S14-p VQQQRAGsrAsAPAt
R15-m1 QQQRAGsrAsAPAtP
S17-p QRAGsrAsAPAtPLs
A20 GsrAsAPAtPLsPtR
T21-p srAsAPAtPLsPtRL
S24-p sAPAtPLsPtRLsRL
T26-p PAtPLsPtRLsRLQE
S29-p PLsPtRLsRLQEkEE
K34-ac RLsRLQEkEELRELN
Y47 LNDRLAVYIDKVRSL
K50 RLAVYIDKVRSLETE
S59 RSLETENSALQLQVT
K80 GRELTGLKALYETEL
K80-ub GRELTGLkALYETEL
K103 DTARERAKLQIELGk
K103-ub DTARERAkLQIELGk
K110-ac kLQIELGkFkAEHDQ
K110-ub kLQIELGkFkAEHDQ
K112-ac QIELGkFkAEHDQLL
K112-ub QIELGkFkAEHDQLL
K124 QLLLNYAKkESDLSG
K124 QLLLNYAKkESDLSG
K124 QLLLNYAKkESDLSG
K125-ub LLLNYAKkESDLSGA
K135 DLSGAQIKLREYEAA
K135-ub DLSGAQIkLREYEAA
Y139 AQIkLREYEAALNSK
K146 YEAALNSKDAALATA
K157 LATALGDKksLEGDL
K157 LATALGDKksLEGDL
K158 ATALGDKKsLEGDLE
K158-ub ATALGDKksLEGDLE
S159-p TALGDKksLEGDLED
K168-ac EGDLEDLkDQIAQLE
K168 EGDLEDLKDQIAQLE
K182 EASLSAAKkQLADET
K182-ub EASLSAAkkQLADET
K182 EASLSAAKkQLADET
K183-ub ASLSAAkkQLADETL
K192-ac LADETLLkVDLENRC
S201-p DLENRCQsLTEDLEF
K210-ub TEDLEFRkNMYEEEI
N211 EDLEFRkNMYEEEIN
Y213 LEFRkNMYEEEINET
S233-p TRLVEVDsGRQIEYE
K242 RQIEYEYKLAQALHE
K262-ac DAQVRLYkEELEQTY
K262-ub DAQVRLYkEELEQTY
K262 DAQVRLYKEELEQTY
T268 YkEELEQTYHAkLEN
Y269 kEELEQTYHAkLENA
K272-ac LEQTYHAkLENARLs
K272-ub LEQTYHAkLENARLs
S279-p kLENARLsSEMNTsT
T284 RLsSEMNTsTVNSAR
S285-p LsSEMNTsTVNSARE
T286 sSEMNTsTVNSAREE
S289 MNTsTVNSAREELME
S303-p ESRMRIEsLSSQLsN
S305 RMRIEsLSSQLsNLQ
S306 MRIEsLSSQLsNLQk
S309-p EsLSSQLsNLQkESR
K313 SQLsNLQKESRACLE
K313-ub SQLsNLQkESRACLE
K331-ac ELEDMLAkERDNSRR
K331-ub ELEDMLAkERDNSRR
S341 DNSRRMLSDREREMA
R343 SRRMLSDREREMAEI
S359-p DQMQQQLsDYEQLLD
Y361 MQQQLsDYEQLLDVK
S376-p LALDMEIsAYRkLLE
K380-ac MEIsAYRkLLEGEEE
K380-ub MEIsAYRkLLEGEEE
K390-ub EGEEERLkLsPsPss
S392-p EEERLkLsPsPssRV
S394-p ERLkLsPsPssRVtV
S396-p LkLsPsPssRVtVsR
S397-p kLsPsPssRVtVsRA
T400-p PsPssRVtVsRAsss
S402-p PssRVtVsRAsssRs
S405-p RVtVsRAsssRsVRT
S406-p VtVsRAsssRsVRTT
S407-p tVsRAsssRsVRTTR
S409-p sRAsssRsVRTTRGK
T412 sssRsVRTTRGKRKR
T413 ssRsVRTTRGKRKRV
S480 IRKIGDTSVSYkYTS
S482 KIGDTSVSYkYTSRY
K484-ac GDTSVSYkYTSRYVL
K484 GDTSVSYKYTSRYVL
K529 WGTGEDVKVILkNSQ
K533-ub EDVKVILkNSQGEEV
S535 VKVILkNSQGEEVAQ
S544-p GEEVAQRsTVFkTTI
K548-ub AQRsTVFkTTIPEEE
A577 ERFHQQGAPRASNKS
  rat

 
T3 _____MATATPVQQR
T5 ___MATATPVQQRAG
S13 PVQQRAGSRASAPAT
R14 VQQRAGSRASAPATP
S16 QRAGSRASAPATPFS
A19 GSRASAPATPFSPTR
T20 SRASAPATPFSPTRL
S23 SAPATPFSPTRLSRL
T25 PATPFSPTRLSRLQE
S28 PFSPTRLSRLQEKEE
K33 RLSRLQEKEELRELN
Y46 LNDRLAVYIDKVRSL
K49 RLAVYIDKVRSLETE
S58 RSLETENSALQLQVT
K79 GRELTGLKALYETEL
K79 GRELTGLKALYETEL
K102 DTARERAKLQIELGk
K102 DTARERAKLQIELGk
K109-ac KLQIELGkFKAEHDQ
K109 KLQIELGKFKAEHDQ
K111 QIELGkFKAEHDQLL
K111 QIELGkFKAEHDQLL
K123 QLLLNYAKKESDLSG
K123 QLLLNYAKKESDLSG
K123 QLLLNYAKKESDLSG
K124 LLLNYAKKESDLSGA
K134 DLSGAQIKLREYEAA
K134 DLSGAQIKLREYEAA
Y138 AQIKLREYEAALNSK
K145 YEAALNSKDAALATA
K156 LATALGDKKSLEGDL
K156 LATALGDKKSLEGDL
K157 ATALGDKKSLEGDLE
K157 ATALGDKKSLEGDLE
S158 TALGDKKSLEGDLED
K167 EGDLEDLKDQIAQLE
K167 EGDLEDLKDQIAQLE
K181 EASLSAAKKQLADET
K181 EASLSAAKKQLADET
K181 EASLSAAKKQLADET
K182 ASLSAAKKQLADETL
K191 LADETLLKVDLENRC
S200 DLENRCQSLTEDLEF
K209 TEDLEFRKNMYEEEI
N210 EDLEFRKNMYEEEIN
Y212 LEFRKNMYEEEINET
S232 TRLVEVDSGRQIEYE
K241 RQIEYEYKLAQALHE
K261 DAQVRLYKEELEQTY
K261 DAQVRLYKEELEQTY
K261 DAQVRLYKEELEQTY
T267 YKEELEQTYHAKLEN
Y268 KEELEQTYHAKLENA
K271 LEQTYHAKLENARLS
K271 LEQTYHAKLENARLS
S278 KLENARLSSEMNTST
T283 RLSSEMNTSTVNSAR
S284 LSSEMNTSTVNSARG
T285 SSEMNTSTVNSARGG
S288 MNTSTVNSARGGMME
S302 ESRMRIESLSSQLSN
S304 RMRIESLSSQLSNLQ
S305 MRIESLSSQLSNLQK
S308 ESLSSQLSNLQKDSR
K312 SQLSNLQKDSRACLE
K312 SQLSNLQKDSRACLE
K330 ELEDMLAKERDNSRR
K330 ELEDMLAKERDNSRR
S340 DNSRRMLSDKEREMA
K342 SRRMLSDKEREMAEI
N358 DQMQQQLNDYEQLLD
Y360 MQQQLNDYEQLLDVK
S375 LALDMEISAYRKLLE
K379 MEISAYRKLLEGEEE
K379 MEISAYRKLLEGEEE
K389 EGEEERLKLsPsPSS
S391-p EEERLKLsPsPSSRV
S393-p ERLKLsPsPSSRVTV
S395 LKLsPsPSSRVTVSR
S396 KLsPsPSSRVTVSRA
T399 PsPSSRVTVSRAsSs
S401 PSSRVTVSRAsSsRs
S404-p RVTVSRAsSsRsVRT
S405 VTVSRAsSsRsVRTT
S406-p TVSRAsSsRsVRTTR
S408-p SRAsSsRsVRTTRGK
T411 sSsRsVRTTRGKRKR
T412 SsRsVRTTRGKRKRV
S479 IRKIGDTSVSYKYTS
S481 KIGDTSVSYKYTSRY
K483 GDTSVSYKYTSRYVL
K483 GDTSVSYKYTSRYVL
K528 WGTGEDVKVVLKNSQ
K532 EDVKVVLKNSQGEEV
S534 VKVVLKNSQGEEVAQ
S543 GEEVAQRSTVFKTTI
K547 AQRSTVFKTTIPEEE
T576-p ERFHQQGtPRASNKS
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