Home

Lamin B1 (human)

Overview Lamin B1 nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Nuclear lamins are cleaved by caspases during apoptosis. Note: This description may include information from UniProtKB. Protein type: Cytoskeletal protein Cellular Component: nucleoplasm; nuclear matrix; lamin filament; nuclear inner membrane; nuclear envelope Molecular Function: phospholipase binding; structural molecule activity Biological Process: apoptosis; cell structure disassembly during apoptosis Reference #:  P20700 (UniProtKB) Alt. Names/Synonyms: ADLD; lamin B1; Lamin-B1; LMN; LMN2; LMNB; LMNB1; MGC111419 Gene Symbols: LMNB1 Molecular weight: 66,408 Da Basal Isoelectric point: 5.11  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Lamin B1 2KPW - A=439-549 (human) 3HN9 - A/C/B=428-550 (human) 3JT0 - A/B=426-558 (human) 3MOV - A/B=311-388 (human) 3TYY - A/B=311-388 (human) 3UMN - A/C/B=428-550 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2KPW 3HN9 3JT0 3MOV 3TYY 3UMN  |  Phospho3D  |  DISEASE 150340 169500  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		T3-p	_____MAtAtPVPPR
0	4		T5-p	___MAtAtPVPPRMG
0	3		S13-p	PVPPRMGsRAGGPtt
0	1		R14	VPPRMGsRAGGPttP
0	15		G16	PRMGsRAGGPttPLs
0	6		T19-p	GsRAGGPttPLsPtR
0	129		T20-p	sRAGGPttPLsPtRL
2	119		S23-p	GGPttPLsPtRLSRL
0	19		T25-p	PttPLsPtRLSRLQE
0	1		S28	PLsPtRLSRLQEKEE
0	3		Y46-p	LNDRLAVyIDkVRSL
0	8		K49-u	RLAVyIDkVRSLETE
0	4		K79-u	GRELTGLkALYETEL
0	2		K102-u	DTARERAkLQIELGk
0	2		K109	kLQIELGKCkAEHDQ
0	6		K109-u	kLQIELGkCkAEHDQ
0	1		K111-a	QIELGkCkAEHDQLL
0	20		K111-u	QIELGkCkAEHDQLL
0	1		K123-a	QLLLNYAkkESDLNG
0	1		K123-u	QLLLNYAkkESDLNG
0	1		K124-u	LLLNYAkkESDLNGA
0	13		K134-u	DLNGAQIkLREyEAA
0	1		Y138-p	AQIkLREyEAALNSk
0	2		K145-u	yEAALNSkDAALATA
0	1		K156-a	LATALGDkksLEGDL
0	2		K156-u	LATALGDkksLEGDL
0	1		K157-a	ATALGDkksLEGDLE
0	10		K157-u	ATALGDkksLEGDLE
0	3		S158-p	TALGDkksLEGDLED
0	1		K167	EGDLEDLKDQIAQLE
0	3		K167-u	EGDLEDLkDQIAQLE
0	1		K181-a	EASLAAAkkQLADET
0	4		K181-u	EASLAAAkkQLADET
0	85		K182-u	ASLAAAkkQLADETL
0	2		S200-p	DLENRCQsLTEDLEF
0	4		K209-u	TEDLEFRksMyEEEI
0	2		S210-p	EDLEFRksMyEEEIN
0	1		Y212-p	LEFRksMyEEEINET
0	5		S232-p	TRLVEVDsGRQIEYE
0	12		K241-u	RQIEYEYkLAQALHE
0	6		K261-u	DAQVRLYkEELEQty
0	1		T267-p	YkEELEQtyHAkLEN
0	6		Y268-p	kEELEQtyHAkLENA
0	22		K271-a	LEQtyHAkLENARLS
0	24		K271-u	LEQtyHAkLENARLS
0	1		S278	kLENARLSSEMNtst
0	1		T283-p	RLSSEMNtstVNsAR
0	17		S284-p	LSSEMNtstVNsARE
0	2		T285-p	SSEMNtstVNsAREE
0	1		S288-p	MNtstVNsAREELME
0	24		S302-p	ESRMRIEsLssQLSN
0	2		S304-p	RMRIEsLssQLSNLQ
0	1		S305-p	MRIEsLssQLSNLQk
0	1		S308	EsLssQLSNLQkESR
0	79		K312-u	sQLSNLQkESRACLE
0	6		K330-u	ELEDLLAkEKDNSRR
0	1		T340-p	DNSRRMLtDkEREMA
0	1		K342-u	SRRMLtDkEREMAEI
0	1		N358	DQMQQQLNDyEQLLD
0	1		Y360-p	MQQQLNDyEQLLDVK
0	5		S375-p	LALDMEIsAYRkLLE
0	55		K379-u	MEIsAYRkLLEGEEE
0	62		K389-u	EGEEERLkLsPsPss
0	29		S391-p	EEERLkLsPsPssRV
1	22		S393-p	ERLkLsPsPssRVtV
2	6		S395-p	LkLsPsPssRVtVsR
0	5		S396-p	kLsPsPssRVtVsRA
0	7		T399-p	PsPssRVtVsRAsss
0	29		S401-p	PssRVtVsRAsssRs
0	107		S404-p	RVtVsRAsssRsVRt
2	96		S405-p	VtVsRAsssRsVRtt
0	37		S406-p	tVsRAsssRsVRttR
0	73		S408-p	sRAsssRsVRttRGK
0	2		T411-p	sssRsVRttRGKRKR
0	3		T412-p	ssRsVRttRGKRKRV
0	3		K483-a	GDTSVSYkYTSRYVL
0	1		K483-u	GDTSVSYkYTSRYVL
0	1		K528-u	WGTGEDVkVILkNsQ
0	10		K532-u	EDVkVILkNsQGEEV
0	5		S534-p	VkVILkNsQGEEVAQ
0	1		S543	GEEVAQRSTVFkTTI
0	16		K547-u	AQRSTVFkTTIPEEE
0	53		T575-p	ELFHQQGtPRASNRS

	mouse
T3-p	_____MAtAtPVQQQ
T5-p	___MAtAtPVQQQRA
S14-p	VQQQRAGsrAsAPAt
R15-m1	QQQRAGsrAsAPAtP
S17-p	QRAGsrAsAPAtPLs
A20	GsrAsAPAtPLsPtR
T21-p	srAsAPAtPLsPtRL
S24-p	sAPAtPLsPtRLsRL
T26-p	PAtPLsPtRLsRLQE
S29-p	PLsPtRLsRLQEKEE
Y47	LNDRLAVYIDKVRSL
K50	RLAVYIDKVRSLETE
K80-u	GRELTGLkALYETEL
K103-u	DTARERAkLQIELGk
K110	kLQIELGKFkAEHDQ
K110-u	kLQIELGkFkAEHDQ
K112	QIELGkFKAEHDQLL
K112-u	QIELGkFkAEHDQLL
K124	QLLLNYAKkESDLSG
K124	QLLLNYAKkESDLSG
K125-u	LLLNYAKkESDLSGA
K135-u	DLSGAQIkLREYEAA
Y139	AQIkLREYEAALNSK
K146	YEAALNSKDAALATA
K157	LATALGDKksLEGDL
K157	LATALGDKksLEGDL
K158	ATALGDKKsLEGDLE
K158-u	ATALGDKksLEGDLE
S159-p	TALGDKksLEGDLED
K168-a	EGDLEDLkDQIAQLE
K168	EGDLEDLKDQIAQLE
K182	EASLSAAKkQLADET
K182-u	EASLSAAkkQLADET
K183-u	ASLSAAkkQLADETL
S201	DLENRCQSLTEDLEF
K210-u	TEDLEFRkNMYEEEI
N211	EDLEFRkNMYEEEIN
Y213	LEFRkNMYEEEINET
S233-p	TRLVEVDsGRQIEYE
K242	RQIEYEYKLAQALHE
K262-u	DAQVRLYkEELEQTY
T268	YkEELEQTYHAkLEN
Y269	kEELEQTYHAkLENA
K272	LEQTYHAKLENARLs
K272-u	LEQTYHAkLENARLs
S279-p	kLENARLsSEMNTsT
T284	RLsSEMNTsTVNSAR
S285-p	LsSEMNTsTVNSARE
T286	sSEMNTsTVNSAREE
S289	MNTsTVNSAREELME
S303	ESRMRIESLSSQLsN
S305	RMRIESLSSQLsNLQ
S306	MRIESLSSQLsNLQk
S309-p	ESLSSQLsNLQkESR
K313-u	SQLsNLQkESRACLE
K331-u	ELEDMLAkERDNSRR
S341	DNSRRMLSDREREMA
R343	SRRMLSDREREMAEI
S359-p	DQMQQQLsDYEQLLD
Y361	MQQQLsDYEQLLDVK
S376-p	LALDMEIsAYRkLLE
K380-u	MEIsAYRkLLEGEEE
K390-u	EGEEERLkLsPsPss
S392-p	EEERLkLsPsPssRV
S394-p	ERLkLsPsPssRVtV
S396-p	LkLsPsPssRVtVsR
S397-p	kLsPsPssRVtVsRA
T400-p	PsPssRVtVsRAsss
S402-p	PssRVtVsRAsssRs
S405-p	RVtVsRAsssRsVRT
S406-p	VtVsRAsssRsVRTT
S407-p	tVsRAsssRsVRTTR
S409-p	sRAsssRsVRTTRGK
T412	sssRsVRTTRGKRKR
T413	ssRsVRTTRGKRKRV
K484	GDTSVSYKYTSRYVL
K484	GDTSVSYKYTSRYVL
K529	WGTGEDVKVILkNSQ
K533-u	EDVKVILkNSQGEEV
S535	VKVILkNSQGEEVAQ
S544-p	GEEVAQRsTVFkTTI
K548-u	AQRsTVFkTTIPEEE
A577	ERFHQQGAPRASNKS

	rat
T3	_____MATATPVQQR
T5	___MATATPVQQRAG
S13	PVQQRAGSRASAPAT
R14	VQQRAGSRASAPATP
S16	QRAGSRASAPATPFS
A19	GSRASAPATPFSPTR
T20	SRASAPATPFSPTRL
S23	SAPATPFSPTRLSRL
T25	PATPFSPTRLSRLQE
S28	PFSPTRLSRLQEKEE
Y46	LNDRLAVYIDKVRSL
K49	RLAVYIDKVRSLETE
K79	GRELTGLKALYETEL
K102	DTARERAKLQIELGk
K109-a	KLQIELGkFKAEHDQ
K109	KLQIELGKFKAEHDQ
K111	QIELGkFKAEHDQLL
K111	QIELGkFKAEHDQLL
K123	QLLLNYAKKESDLSG
K123	QLLLNYAKKESDLSG
K124	LLLNYAKKESDLSGA
K134	DLSGAQIKLREYEAA
Y138	AQIKLREYEAALNSK
K145	YEAALNSKDAALATA
K156	LATALGDKKSLEGDL
K156	LATALGDKKSLEGDL
K157	ATALGDKKSLEGDLE
K157	ATALGDKKSLEGDLE
S158	TALGDKKSLEGDLED
K167	EGDLEDLKDQIAQLE
K167	EGDLEDLKDQIAQLE
K181	EASLSAAKKQLADET
K181	EASLSAAKKQLADET
K182	ASLSAAKKQLADETL
S200	DLENRCQSLTEDLEF
K209	TEDLEFRKNMYEEEI
N210	EDLEFRKNMYEEEIN
Y212	LEFRKNMYEEEINET
S232	TRLVEVDSGRQIEYE
K241	RQIEYEYKLAQALHE
K261	DAQVRLYKEELEQTY
T267	YKEELEQTYHAKLEN
Y268	KEELEQTYHAKLENA
K271	LEQTYHAKLENARLS
K271	LEQTYHAKLENARLS
S278	KLENARLSSEMNTST
T283	RLSSEMNTSTVNSAR
S284	LSSEMNTSTVNSARG
T285	SSEMNTSTVNSARGG
S288	MNTSTVNSARGGMME
S302	ESRMRIESLSSQLSN
S304	RMRIESLSSQLSNLQ
S305	MRIESLSSQLSNLQK
S308	ESLSSQLSNLQKDSR
K312	SQLSNLQKDSRACLE
K330	ELEDMLAKERDNSRR
S340	DNSRRMLSDKEREMA
K342	SRRMLSDKEREMAEI
N358	DQMQQQLNDYEQLLD
Y360	MQQQLNDYEQLLDVK
S375	LALDMEISAYRKLLE
K379	MEISAYRKLLEGEEE
K389	EGEEERLKLSPSPSS
S391	EEERLKLSPSPSSRV
S393	ERLKLSPSPSSRVTV
S395	LKLSPSPSSRVTVSR
S396	KLSPSPSSRVTVSRA
T399	PSPSSRVTVSRAsSs
S401	PSSRVTVSRAsSsRs
S404-p	RVTVSRAsSsRsVRT
S405	VTVSRAsSsRsVRTT
S406-p	TVSRAsSsRsVRTTR
S408-p	SRAsSsRsVRTTRGK
T411	sSsRsVRTTRGKRKR
T412	SsRsVRTTRGKRKRV
K483	GDTSVSYKYTSRYVL
K483	GDTSVSYKYTSRYVL
K528	WGTGEDVKVVLKNSQ
K532	EDVKVVLKNSQGEEV
S534	VKVVLKNSQGEEVAQ
S543	GEEVAQRSTVFKTTI
K547	AQRSTVFKTTIPEEE
T576	ERFHQQGTPRASNKS

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.