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TICAM1 (human)

Overview TICAM1 an adaptor protein involved in innate immunity against invading pathogens. Associates with TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TICAM1 recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Interacts with the TIR domain of TLR3. Interacts with AZI2, TBK1, IRF3 and IRF7. Interacts with TICAM2 in TLR4 recruitment. Interaction with PIAS4 inhibits the TICAM1-induced NF-kappa-B, IRF and IFNB1 activation. Interacts with IKBKB and IKBKE. Interaction with SARM1 blocks TICAM1-dependent transcription factor activation. Interacts with TRAF3. Interacts with TRAFD1. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold; Apoptosis Cellular Component: endosome membrane; cytosol Molecular Function: protein binding; signal transducer activity; protein kinase binding Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of nitric oxide biosynthetic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein binding; apoptosis; MyD88-independent toll-like receptor signaling pathway; regulation of protein homodimerization activity; positive regulation of interleukin-6 production; toll-like receptor 3 signaling pathway; positive regulation of tumor necrosis factor production; Toll signaling pathway; activation of NF-kappaB transcription factor; response to exogenous dsRNA; positive regulation of chemokine biosynthetic process; positive regulation of protein ubiquitination; macrophage activation during immune response; positive regulation of interferon-beta biosynthetic process; positive regulation of B cell proliferation; lipopolysaccharide-mediated signaling pathway; positive regulation of interferon type I production; innate immune response; inflammatory response; toll-like receptor 4 signaling pathway; defense response to virus Reference #:  Q8IUC6 (UniProtKB) Alt. Names/Synonyms: MGC35334; Proline-rich, vinculin and TIR domain-containing protein B; PRVTIRB; Putative NF-kappa-B-activating protein 502H; TCAM1; TICAM-1; TICAM1; TIR domain containing adaptor inducing interferon-beta; TIR domain-containing adapter molecule 1; TIR domain-containing adapter protein inducing IFN-beta; TIR domain-containing adaptor molecule 1; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; toll-like receptor adaptor molecule 1; TRIF Gene Symbols: TICAM1 Molecular weight: 76,422 Da Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states CST Pathways:  Toll-like Receptors Pathway Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TICAM1 3RC4 - B=360-372 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S212-p	SNLEISQsPTMPFLS
0	1		S388-p	LFPSSLEsssEQKFY
0	1		S389-p	FPSSLEsssEQKFYN
0	1		S390-p	PSSLEsssEQKFYNF
0	1		S500-p	ESSPAQLsSDTASLL
0	1		Y570-p	AAALNAAySAyLQSy
0	1		Y573-p	LNAAySAyLQSyLSY
0	1		Y577-p	ySAyLQSyLSYQAQM
0	2		K707-u	GSQAPEDkTQEAE__

	mouse
S211	SHLEISQSPTLAFLS
S389	TSPVLDHSETSDQKF
T391	PVLDHSETSDQKFYN
S392	VLDHSETSDQKFYNF
S502	ECSQAQLSPDTTRLL
Y572	VAAISAAYTAYVHSY
Y575	ISAAYTAYVHSYRAW
Y579	YTAYVHSYRAWQAEM
K708	GAQSSDDKTECSENP

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