actin-binding regulatory subunit of protein phosphatase 1 (PP1). The actin-binding domain of spinophilin is necessary and sufficient for targeting of spinophilin to dendrites and dendritic spines. May play a role in establishing a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Interacts with p14-ARF. Contains one PDZ/DHR domain. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Protein phosphatase, regulatory subunit
Cellular Component: nucleoplasm; cytoskeleton; adherens junction; lamellipodium; cytoplasm; dendritic spine; plasma membrane; synapse; protein phosphatase type 1 complex; filopodium
Molecular Function: protein binding; actin binding; protein phosphatase inhibitor activity; protein phosphatase 1 binding
Biological Process: nervous system development; regulation of cell growth by extracellular stimulus; cell migration; filopodium formation; RNA splicing; regulation of exit from mitosis; negative regulation of cell growth; cell differentiation; cell cycle arrest; regulation of cell proliferation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.