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K86 (human)

Overview K86 Defects in KRT86 are a cause of monilethrix (MLTRX). Monilethrix is an autosomal dominant hair disorder characterized clinically by alopecia and follicular papules. Affected hairs have uniform elliptical nodes of normal thickness and intermittent constrictions, internodes at which the hair easily breaks. Usually only the scalp is involved, but in severe forms, the secondary sexual hair, eyebrows, eyelashes, and nails may also be affected. Belongs to the intermediate filament family. Note: This description may include information from UniProtKB. Protein type: Cytoskeletal protein; Motility/polarity/chemotaxis Cellular Component: keratin filament; intermediate filament Molecular Function: structural molecule activity Biological Process: cytoskeleton organization and biogenesis Reference #:  O43790 (UniProtKB) Alt. Names/Synonyms: FLJ25176; Hair keratin K2.11; hard keratin, type II, 6; Hb1; HB6; hHb6; K86; keratin 86; keratin protein HB6; keratin, hair, basic, 6 (monilethrix); Keratin, type II cuticular Hb6; Keratin-86; KRT86; KRTHB1; KRTHB6; MNX; Type II hair keratin Hb6; Type-II keratin Kb26 Gene Symbols: KRT86 Molecular weight: 53,501 Da Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states

Select Structure to View Below K86

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  DISEASE 158000 601928  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	4		S49-p	TGGFGSHsVCGGFRA
0	4		K132-u	RFLEQQNkLLETKLQ
0	1		K193-m2	VLEGYKKkYEEEVSL
0	1		K222-m2	VDCAYLRkSDLEANV
0	26		Y282-p	IAEIKAQyDDIVTRS
0	6		K300-u	AESWYRSkCEEMkAT
0	7		K305-u	RSkCEEMkATVIRHG
0	7		K319-u	GETLRRTkEEINELN
0	6		K340-u	TAEVENAkCQNSkLE
0	3		K345-u	NAkCQNSkLEAAVAQ
0	7		K367-u	ALSDARCkLAELEGA
0	1		K377-m2	ELEGALQkAkQDMAC
0	7		K377-u	ELEGALQkAkQDMAC
0	7		K379-u	EGALQkAkQDMACLI
0	1		S455-p	VVSTRVSsVPSNsNV
0	1		S460-p	VSsVPSNsNVVVGtT
0	1		T466-p	NsNVVVGtTNACAPS

	mouse
S49-p	SGGFGSQsVCGAFRS
K132-u	RFLEQQNkLLETKWQ
R193	SMEGYKKRYEEEVSL
K222	VDCAYLRKSDLEANA
Y282	VAEIKAQYDDIASRS
K300	AESWYRTKCEEIKAT
K305	RTKCEEIKATVIRHG
R319	GETLRRTREEINELN
K340	TAEIENAKCQNTKLE
K345	NAKCQNTKLEAAVTQ
K367	ALADARCKLAELEGA
K377	ELEGALQKAKQDMAC
K377	ELEGALQKAKQDMAC
K379	EGALQKAKQDMACLL
S455	AVNTRVCSAPCSGNV
G460	VCSAPCSGNVVVGTP
T466	SGNVVVGTPNACAPC

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