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Protein Page:
CCR5 (human)

Overview
CCR5 a 7-transmembrane G-linked receptor for a number of inflammatory C-C type chemokines including MIP-1-alpha, MIP-1-beta and RANTES. Transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (along with CD4) for HIV-1 R5 isolates. Interacts with PRAF2. Interacts with HIV-1 surface protein gp120. Efficient ligand binding to CCL3/MIP-1alpha and CCR4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on S6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2. Variations in CCR5 are associated with resistance or susceptibility to immunodeficiency virus type 1 (resistance or susceptibility to HIV-1). Variations in CCR5 gene also influence the rate of progression to AIDS after infection. R60S variant, a naturally occurring mutation in a conserved residue in the first intracellular domain of CCR5, results in reduced amounts of the protein in the membrane and consequently may be associated with reduced susceptibility to infection by microbes that depend on these molecules as their receptors. Variations in CCR5 are associated with susceptibility to West Nile virus (WNV) infection Note: This description may include information from UniProtKB.
Protein type: Receptor, cytokine; Receptor, GPCR; Membrane protein, integral; Motility/polarity/chemotaxis; Membrane protein, multi-pass; GPCR, family 1
Cellular Component: cell surface; integral to plasma membrane; cytoplasm; plasma membrane; endosome; external side of plasma membrane
Molecular Function: protein binding; C-C chemokine receptor activity; chemokine receptor activity; C-C chemokine binding; coreceptor activity; actin binding; phosphoinositide phospholipase C activity
Biological Process: viral reproduction; calcium-mediated signaling; MAPKKK cascade; chemotaxis; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; cell-cell signaling; calcium ion transport; dendritic cell chemotaxis; cellular defense response; entry into host cell; immune response; blood vessel remodeling; inflammatory response
Reference #:  P51681 (UniProtKB)
Alt. Names/Synonyms: C-C chemokine receptor type 5; C-C CKR-5; C-C motif chemokine receptor 5 A159A; CC-CKR-5; CCCKR5; CCR-5; CCR5; CD195; chemokine (C-C motif) receptor 5; chemokine receptor CCR5; CHEMR13; CKR-5; CKR5; CMKBR5; FLJ78003; HIV-1 fusion coreceptor; IDDM22
Gene Symbols: CCR5
Molecular weight: 40,524 Da
Basal Isoelectric point: 9.21  Predict pI for various phosphorylation states
Select Structure to View Below

CCR5

Protein Structure Not Found.


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Sites Implicated In
activity, inhibited: S336‑p, S349‑p
molecular association, regulation: S336‑p, S337‑p, S342‑p, S349‑p
phosphorylation: Y339‑p
receptor desensitization, altered: S336‑p, S337‑p, S342‑p, S349‑p
receptor internalization, altered: S336‑p, S337‑p, S342‑p, S349‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
4 0 S336-p QEAPERAssVyTRsT
3 0 S337-p EAPERAssVyTRsTG
1 0 Y339-p PERAssVyTRsTGEQ
3 0 S342-p AssVyTRsTGEQEIs
6 0 S349-p sTGEQEIsVGL____
  mouse

 
S338 QDNPDRASSVYTRST
S339 DNPDRASSVYTRSTG
Y341 PDRASSVYTRSTGEH
S344 ASSVYTRSTGEHEVS
S351 STGEHEVSTGL____
  rat

 
S338 QVNPDRVSSVYTRST
S339 VNPDRVSSVYTRSTG
Y341 PDRVSSVYTRSTGEQ
S344 VSSVYTRSTGEQEVS
S351 STGEQEVSTGL____
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