Home

KLK3 (human)

Overview KLK3 Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. Forms heterodimer with SERPINA5. Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. Belongs to the peptidase S1 family. Kallikrein subfamily. Note: This description may include information from UniProtKB. Protein type: EC 3.4.21.77; Secreted, signal peptide; Secreted; Protease Cellular Component: extracellular region Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity Biological Process: negative regulation of angiogenesis; proteolysis Reference #:  P07288 (UniProtKB) Alt. Names/Synonyms: APS; Gamma-seminoprotein; hK3; Kallikrein-3; kallikrein-related peptidase 3; KLK2A1; KLK3; P-30 antigen; prostate specific antigen; Prostate-specific antigen; PSA; Semenogelase; Seminin Gene Symbols: KLK3 Molecular weight: 28,741 Da Basal Isoelectric point: 7.61  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below KLK3 1PFA - A=10-261 (human) 2PSA - A=25-261 (human) 2ZCH - P=25-261 (human) 2ZCK - P=25-261 (human) 2ZCL - P=25-261 (human) 3QUM - Q/P=25-261 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1PFA 2PSA 2ZCH 2ZCK 2ZCL 3QUM  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T143-p	VKVMDLPtQEPALGT
0	1		T167-p	IEPEEFLtPKKLQCV
0	2		K251-u	TKVVHYRkWIkDTIV
0	2		K254-u	VHYRkWIkDTIVANP

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.