Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. Forms heterodimer with SERPINA5. Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. Belongs to the peptidase S1 family. Kallikrein subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 188.8.131.52; Protease; Secreted; Secreted, signal peptide
Cellular Component: extracellular region
Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity
Biological Process: negative regulation of angiogenesis; cellular protein metabolic process; proteolysis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.