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GAP43 (human)

Overview GAP43 This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence. Belongs to the neuromodulin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Cell surface Cellular Component: filopodium membrane; axon; plasma membrane; synapse; cell junction Molecular Function: calmodulin binding; protein binding Biological Process: glial cell differentiation; cell fate commitment; tissue regeneration; regulation of growth; axon choice point recognition; protein kinase C activation; response to wounding; regulation of filopodium formation Reference #:  P17677 (UniProtKB) Alt. Names/Synonyms: Axonal membrane protein GAP-43; B-50; calmodulin-binding protein P-57; GAP43; growth associated protein 43; Growth-associated protein 43; nerve growth-related peptide GAP43; NEUM; Neural phosphoprotein B-50; Neuromodulin; neuron growth-associated protein 43; pp46; protein F1 Gene Symbols: GAP43 Molecular weight: 24,803 Da Basal Isoelectric point: 4.64  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below GAP43 4E53 - A/B=34-57 (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K9	LCCMRRTKQVEKNDD
0	1		K13	RRTKQVEKNDDDQKI
0	12		K19	EKNDDDQKIEQDGIk
0	16		K26-u	KIEQDGIkPEDkAHK
0	5		K30-u	DGIkPEDkAHKAAtk
0	3		T36-p	DkAHKAAtkIQAsFR
0	8		K37-u	kAHKAAtkIQAsFRG
14	11		S41-p	AAtkIQAsFRGHITR
0	3		K52	HITRKKLKGEKKDDV
0	6		K55	RKKLKGEKKDDVQAA
0	2		K56	KKLKGEKKDDVQAAE
0	8		N67	QAAEAEANKkDEAPV
0	12		K69-u	AEAEANKkDEAPVAD
0	9		K80-u	PVADGVEkkGEGTTT
0	11		K81-u	VADGVEkkGEGTTTA
0	3		T85	VEkkGEGTTTAEAAP
0	1		T86	EkkGEGTTTAEAAPA
2	2		T87	kkGEGTTTAEAAPAT
2	2		A88	kGEGTTTAEAAPATG
2	5		T94	TAEAAPATGSkPDEP
2	11		G95	AEAAPATGSkPDEPG
0	1		K97-u	AAPATGSkPDEPGkA
0	3		G102	GSkPDEPGkAGEtPs
0	3		K103-u	SkPDEPGkAGEtPsE
0	1		T107-p	EPGkAGEtPsEEkkG
0	2		S109-p	GkAGEtPsEEkkGEG
0	9		K112-u	GEtPsEEkkGEGDAA
0	5		K113-u	EtPsEEkkGEGDAAT
0	2		S131-p	APQAPASsEEkAGSA
0	14		K134-u	APASsEEkAGSAETE
0	2		S137	SsEEkAGSAETEsAt
0	2		S142-p	AGSAETEsAtkAstD
0	1		T144-p	SAETEsAtkAstDNs
0	3		K145-u	AETEsAtkAstDNsP
0	3		S147-p	TEsAtkAstDNsPSs
0	2		T148-p	EsAtkAstDNsPSsk
0	6		S151-p	tkAstDNsPSskAED
0	3		S153	AstDNsPSskAEDAP
0	3		S154-p	stDNsPSskAEDAPA
0	1		K155-u	tDNsPSskAEDAPAK
0	1		T175	ADVPAAVTAAAATtP
1	12		T181-p	VTAAAATtPAAEDAA
0	1		A189	PAAEDAAAKATAQPP
0	1		T199	TAQPPTETGESSQAE
2	2		S202	PPTETGESSQAEENI
2	2		S203	PTETGESSQAEENIE
0	1		I209	SSQAEENIEAVDETk
0	1		K216-m1	IEAVDETkPKESARQ

	mouse
K9-u	LCCMRRTkQVEkNDE
K13-u	RRTkQVEkNDEDQkI
K19-u	EkNDEDQkIEQDGVk
K26-u	kIEQDGVkPEDkAHK
K30-u	DGVkPEDkAHKAAtk
T36-p	DkAHKAAtkIQAsFR
K37-u	kAHKAAtkIQAsFRG
S41-p	AAtkIQAsFRGHITR
K52	HITRKKLKGEKkGDA
K55	RKKLKGEKkGDAPAA
K56-u	KKLKGEKkGDAPAAE
K67-u	PAAEAEAkEkDDAPV
K69-u	AEAEAkEkDDAPVAD
K80-u	PVADGVEkkEGDGsA
K81-u	VADGVEkkEGDGsAt
S86-p	EkkEGDGsAttDAAP
A87	kkEGDGsAttDAAPA
T88-p	kEGDGsAttDAAPAt
T89-p	EGDGsAttDAAPAts
T95-p	ttDAAPAtsPkAEEP
S96-p	tDAAPAtsPkAEEPs
K98-u	AAPAtsPkAEEPskA
S103-p	sPkAEEPskAGDAPs
K104-u	PkAEEPskAGDAPsE
A108	EPskAGDAPsEEkkG
S110-p	skAGDAPsEEkkGEG
K113-u	GDAPsEEkkGEGDAA
K114-u	DAPsEEkkGEGDAAP
S122-p	GEGDAAPsEEkAGsA
K125-u	DAAPsEEkAGsAETE
S128-p	PsEEkAGsAETEsAA
S133-p	AGsAETEsAAkAttD
A135	sAETEsAAkAttDNs
K136-u	AETEsAAkAttDNsP
T138-p	TEsAAkAttDNsPss
T139-p	EsAAkAttDNsPssk
S142-p	AkAttDNsPsskAED
S144-p	AttDNsPsskAEDGP
S145-p	ttDNsPsskAEDGPA
K146-u	tDNsPsskAEDGPAK
T166-gl	ADVPAAVtDAAATtP
T172-p	VtDAAATtPAAEDAA
T180-p	PAAEDAAtKAAQPPT
T189-p	AAQPPTEtAEssQAE
S192-p	PPTEtAEssQAEEEk
S193-p	PTEtAEssQAEEEkD
K199-u	ssQAEEEkDAVDEAK
K206	kDAVDEAKPKESARQ

	rat
K9	LCCMRRTKQVEKNDE
K13	RRTKQVEKNDEDQkI
K19-u	EKNDEDQkIEQDGVk
K26-u	kIEQDGVkPEDkAHK
K30-u	DGVkPEDkAHKAATk
T36	DkAHKAATkIQAsFR
K37-u	kAHKAATkIQAsFRG
S41-p	AATkIQAsFRGHITR
K52-u	HITRKKLkDEkkGDA
K55-u	RKKLkDEkkGDAPAA
K56-u	KKLkDEkkGDAPAAE
K67-u	PAAEAEAkEkDDAPV
K69-u	AEAEAkEkDDAPVAD
K80-u	PVADGVEkkEGDGSA
K81-u	VADGVEkkEGDGSAt
S86	EkkEGDGSAttDAAP
A87	kkEGDGSAttDAAPA
T88-p	kEGDGSAttDAAPAt
T89-p	EGDGSAttDAAPAts
T95-p	ttDAAPAtsPKAEEP
S96-p	tDAAPAtsPKAEEPS
K98	AAPAtsPKAEEPSKA
S103	sPKAEEPSKAGDAPS
K104	PKAEEPSKAGDAPSE
A108	EPSKAGDAPSEEKKG
S110	SKAGDAPSEEKKGEG
K113	GDAPSEEKKGEGDAA
K114	DAPSEEKKGEGDAAP
S122	GEGDAAPSEEkAGSA
K125-u	DAAPSEEkAGSAETE
S128	PSEEkAGSAETESAA
S133	AGSAETESAAKATTD
A135	SAETESAAKATTDNS
K136	AETESAAKATTDNSP
T138	TESAAKATTDNSPSS
T139	ESAAKATTDNSPSSK
S142	AKATTDNSPSSKAED
S144	ATTDNSPSSKAEDGP
S145	TTDNSPSSKAEDGPA
K146	TDNSPSSKAEDGPAK
T166	ADVPAAVTDAAATtP
T172-p	VTDAAATtPAAEDAA
A179	tPAAEDAAKAAQPPT
T188	AAQPPTETAEssQAE
S191-p	PPTETAEssQAEEEK
S192-p	PTETAEssQAEEEKE
K198	ssQAEEEKEAVDEAK
K205	KEAVDEAKPKESARQ

	cow
K9	LCCMRRTKQVEKNDE
K13	RRTKQVEKNDEDQKI
K19	EKNDEDQKIEQDGIK
K26	KIEQDGIKPEDKAHK
K30	DGIKPEDKAHKAATK
T36	DKAHKAATKIQAsFR
K37	KAHKAATKIQAsFRG
S41-p	AATKIQAsFRGHITR
K52	HITRKKLKGEKKGDA
K55	RKKLKGEKKGDAPAA
K56	KKLKGEKKGDAPAAE
N67	PAAEAEANEKDEAAV
K69	AEAEANEKDEAAVAE
K80	AVAEGTEKKEGEGSt
K81	VAEGTEKKEGEGStP
S86	EKKEGEGStPAEAAP
T87-p	KKEGEGStPAEAAPG
P88	KEGEGStPAEAAPGA
A89	EGEGStPAEAAPGAG
A95	PAEAAPGAGPKPEEK
G96	AEAAPGAGPKPEEKT
K98	AAPGAGPKPEEKTGK
G104	PKPEEKTGKAGETPS
K105	KPEEKTGKAGETPSE
T109	KTGKAGETPSEEKKG
S111	GKAGETPSEEKKGEG
K114	GETPSEEKKGEGAPD
K115	ETPSEEKKGEGAPDA
S135	APQAPAPSEEKAGSA
K138	APAPSEEKAGSAETE
S141	PSEEKAGSAETESAT
S146	AGSAETESATKASTD
T148	SAETESATKASTDNs
K149	AETESATKASTDNsP
S151	TESATKASTDNsPSS
T152	ESATKASTDNsPSSK
S155-p	TKASTDNsPSSKAED
S157	ASTDNsPSSKAEDAP
S158	STDNsPSSKAEDAPA
K159	TDNsPSSKAEDAPAK
T179	ADVPAAVTAAAATAP
A185	VTAAAATAPAAEDAA
A193	PAAEDAAAMATAQPP
T203	TAQPPTETAESSQAE
S206	PPTETAESSQAEEKI
S207	PTETAESSQAEEKIE
I213	SSQAEEKIEAVDETK
K220	IEAVDETKPKDSARQ

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