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Protein Page:
GAP43 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GAP43 This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence. Belongs to the neuromodulin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell surface
Cellular Component: filopodium membrane; axon; cytoplasm; plasma membrane; synapse; cell junction
Molecular Function: calmodulin binding; protein binding
Biological Process: cell fate commitment; glial cell differentiation; tissue regeneration; regulation of growth; axon choice point recognition; protein kinase C activation; response to wounding; regulation of filopodium formation
Reference #:  P17677 (UniProtKB)
Alt. Names/Synonyms: Axonal membrane protein GAP-43; B-50; calmodulin-binding protein P-57; GAP43; growth associated protein 43; Growth-associated protein 43; nerve growth-related peptide GAP43; NEUM; Neural phosphoprotein B-50; Neuromodulin; neuron growth-associated protein 43; pp46; protein F1
Gene Symbols: GAP43
Molecular weight: 24,803 Da
Basal Isoelectric point: 4.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GAP43

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K9 LCCMRRTKQVEKNDD
0 1 K13 RRTKQVEKNDDDQKI
0 12 K19 EKNDDDQKIEQDGIK
0 16 K26 KIEQDGIKPEDKAHK
0 5 K30 DGIKPEDKAHKAAtk
0 3 T36-p DKAHKAAtkIQAsFR
0 8 K37-ub KAHKAAtkIQAsFRG
14 11 S41-p AAtkIQAsFRGHITR
0 3 K52 HITRKKLKGEKKDDV
0 6 K55 RKKLKGEKKDDVQAA
0 2 K56 KKLKGEKKDDVQAAE
0 8 N67 QAAEAEANKKDEAPV
0 12 K69 AEAEANKKDEAPVAD
0 9 K80 PVADGVEKKGEGTTT
0 11 K81 VADGVEKKGEGTTTA
0 3 T85 VEKKGEGTTTAEAAP
0 1 T86 EKKGEGTTTAEAAPA
2 2 T87 KKGEGTTTAEAAPAT
2 2 A88 KGEGTTTAEAAPATG
2 6 T94 TAEAAPATGSKPDEP
2 12 G95 AEAAPATGSKPDEPG
0 1 K97 AAPATGSKPDEPGKA
0 3 G102 GSKPDEPGKAGEtPs
0 3 K103 SKPDEPGKAGEtPsE
0 2 T107-p EPGKAGEtPsEEKKG
0 2 S109-p GKAGEtPsEEKKGEG
0 9 K112 GEtPsEEKKGEGDAA
0 5 K113 EtPsEEKKGEGDAAT
0 2 S131-p APQAPASsEEKAGSA
0 14 K134 APASsEEKAGSAETE
0 2 S137 SsEEKAGSAETEsAt
0 2 S142-p AGSAETEsAtKAstD
0 1 T144-p SAETEsAtKAstDNs
0 3 K145 AETEsAtKAstDNsP
0 3 S147-p TEsAtKAstDNsPSs
0 2 T148-p EsAtKAstDNsPSsK
0 8 S151-p tKAstDNsPSsKAED
0 3 S153 AstDNsPSsKAEDAP
0 4 S154-p stDNsPSsKAEDAPA
0 1 K155 tDNsPSsKAEDAPAK
0 1 T175 ADVPAAVTAAAATtP
1 12 T181-p VTAAAATtPAAEDAA
0 1 A189 PAAEDAAAKATAQPP
0 1 T199 TAQPPTETGESsQAE
2 2 S202 PPTETGESsQAEENI
2 2 S203-p PTETGESsQAEENIE
0 1 I209 SsQAEENIEAVDETk
0 1 K216-m1 IEAVDETkPKESARQ
  mouse

 
K9-ub LCCMRRTkQVEkNDE
K13-ub RRTkQVEkNDEDQkI
K19-ub EkNDEDQkIEQDGVk
K26-ub kIEQDGVkPEDkAHK
K30-ub DGVkPEDkAHKAAtk
T36-p DkAHKAAtkIQAsFR
K37-ub kAHKAAtkIQAsFRG
S41-p AAtkIQAsFRGHITR
K52 HITRKKLKGEKkGDA
K55 RKKLKGEKkGDAPAA
K56-ub KKLKGEKkGDAPAAE
K67-ub PAAEAEAkEkDDAPV
K69-ub AEAEAkEkDDAPVAD
K80-ub PVADGVEkkEGDGsA
K81-ub VADGVEkkEGDGsAt
S86-p EkkEGDGsAttDAAP
A87 kkEGDGsAttDAAPA
T88-p kEGDGsAttDAAPAt
T89-p EGDGsAttDAAPAts
T95-p ttDAAPAtsPkAEEP
S96-p tDAAPAtsPkAEEPs
K98-ub AAPAtsPkAEEPskA
S103-p sPkAEEPskAGDAPs
K104-ub PkAEEPskAGDAPsE
A108 EPskAGDAPsEEkkG
S110-p skAGDAPsEEkkGEG
K113-ub GDAPsEEkkGEGDAA
K114-ub DAPsEEkkGEGDAAP
S122-p GEGDAAPsEEkAGsA
K125-ub DAAPsEEkAGsAETE
S128-p PsEEkAGsAETEsAA
S133-p AGsAETEsAAkAttD
A135 sAETEsAAkAttDNs
K136-ub AETEsAAkAttDNsP
T138-p TEsAAkAttDNsPss
T139-p EsAAkAttDNsPssk
S142-p AkAttDNsPsskAED
S144-p AttDNsPsskAEDGP
S145-p ttDNsPsskAEDGPA
K146-ub tDNsPsskAEDGPAK
T166-gl ADVPAAVtDAAATtP
T172-p VtDAAATtPAAEDAA
T180-p PAAEDAAtKAAQPPT
T189-p AAQPPTEtAEssQAE
S192-p PPTEtAEssQAEEEk
S193-p PTEtAEssQAEEEkD
K199-ub ssQAEEEkDAVDEAK
K206 kDAVDEAKPKESARQ
  rat

 
K9 LCCMRRTKQVEKNDE
K13 RRTKQVEKNDEDQkI
K19-ub EKNDEDQkIEQDGVk
K26-ub kIEQDGVkPEDkAHK
K30-ub DGVkPEDkAHKAATk
T36 DkAHKAATkIQAsFR
K37-ub kAHKAATkIQAsFRG
S41-p AATkIQAsFRGHITR
K52-ub HITRKKLkDEkkGDA
K55-ub RKKLkDEkkGDAPAA
K56-ub KKLkDEkkGDAPAAE
K67-ub PAAEAEAkEkDDAPV
K69-ub AEAEAkEkDDAPVAD
K80-ub PVADGVEkkEGDGsA
K81-ub VADGVEkkEGDGsAt
S86-p EkkEGDGsAttDAAP
A87 kkEGDGsAttDAAPA
T88-p kEGDGsAttDAAPAt
T89-p EGDGsAttDAAPAts
T95-p ttDAAPAtsPKAEEP
S96-p tDAAPAtsPKAEEPS
K98 AAPAtsPKAEEPSKA
S103 sPKAEEPSKAGDAPS
K104 PKAEEPSKAGDAPSE
A108 EPSKAGDAPSEEKKG
S110 SKAGDAPSEEKKGEG
K113 GDAPSEEKKGEGDAA
K114 DAPSEEKKGEGDAAP
S122 GEGDAAPSEEkAGSA
K125-ub DAAPSEEkAGSAETE
S128 PSEEkAGSAETESAA
S133 AGSAETESAAKATTD
A135 SAETESAAKATTDNS
K136 AETESAAKATTDNSP
T138 TESAAKATTDNSPSS
T139 ESAAKATTDNSPSSK
S142 AKATTDNSPSSKAED
S144 ATTDNSPSSKAEDGP
S145 TTDNSPSSKAEDGPA
K146 TDNSPSSKAEDGPAK
T166 ADVPAAVTDAAATtP
T172-p VTDAAATtPAAEDAA
A179 tPAAEDAAKAAQPPT
T188 AAQPPTETAEssQAE
S191-p PPTETAEssQAEEEK
S192-p PTETAEssQAEEEKE
K198 ssQAEEEKEAVDEAK
K205 KEAVDEAKPKESARQ
  cow

 
K9 LCCMRRTKQVEKNDE
K13 RRTKQVEKNDEDQKI
K19 EKNDEDQKIEQDGIK
K26 KIEQDGIKPEDKAHK
K30 DGIKPEDKAHKAATK
T36 DKAHKAATKIQAsFR
K37 KAHKAATKIQAsFRG
S41-p AATKIQAsFRGHITR
K52 HITRKKLKGEKKGDA
K55 RKKLKGEKKGDAPAA
K56 KKLKGEKKGDAPAAE
N67 PAAEAEANEKDEAAV
K69 AEAEANEKDEAAVAE
K80 AVAEGTEKKEGEGSt
K81 VAEGTEKKEGEGStP
S86 EKKEGEGStPAEAAP
T87-p KKEGEGStPAEAAPG
P88 KEGEGStPAEAAPGA
A89 EGEGStPAEAAPGAG
A95 PAEAAPGAGPKPEEK
G96 AEAAPGAGPKPEEKT
K98 AAPGAGPKPEEKTGK
G104 PKPEEKTGKAGETPS
K105 KPEEKTGKAGETPSE
T109 KTGKAGETPSEEKKG
S111 GKAGETPSEEKKGEG
K114 GETPSEEKKGEGAPD
K115 ETPSEEKKGEGAPDA
S135 APQAPAPSEEKAGSA
K138 APAPSEEKAGSAETE
S141 PSEEKAGSAETESAT
S146 AGSAETESATKASTD
T148 SAETESATKASTDNs
K149 AETESATKASTDNsP
S151 TESATKASTDNsPSS
T152 ESATKASTDNsPSSK
S155-p TKASTDNsPSSKAED
S157 ASTDNsPSSKAEDAP
S158 STDNsPSSKAEDAPA
K159 TDNsPSSKAEDAPAK
T179 ADVPAAVTAAAATAP
A185 VTAAAATAPAAEDAA
A193 PAAEDAAAMATAQPP
T203 TAQPPTETAESSQAE
S206 PPTETAESSQAEEKI
S207 PTETAESSQAEEKIE
I213 SSQAEEKIEAVDETK
K220 IEAVDETKPKDSARQ
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