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Protein Page:
HLAA iso36 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HLAA iso36 Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family. Note: This description may include information from UniProtKB.
Protein type: Immunoglobulin superfamily; Membrane protein, integral
Cellular Component: Golgi membrane; Golgi apparatus; phagocytic vesicle membrane; cell surface; membrane; early endosome membrane; endoplasmic reticulum; integral to plasma membrane; plasma membrane; MHC class I protein complex; Golgi medial cisterna
Molecular Function: protein binding; peptide antigen binding; beta-2-microglobulin binding; T cell receptor binding; TAP binding; receptor binding
Biological Process: regulation of immune response; viral reproduction; detection of bacterium; positive regulation of T cell mediated cytotoxicity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of defense response to virus by virus; protection from natural killer cell mediated cytotoxicity; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of peptide antigen via MHC class I; positive regulation of interferon-gamma production; antigen processing and presentation of exogenous peptide antigen via MHC class I; immune response
Reference #:  P30455 (UniProtKB)
Alt. Names/Synonyms: HLA class I histocompatibility antigen, A-1 alpha; HLA-A; HLAA; leukocyte antigen class I-A; major histocompatibility complex, class I, A; MHC class I antigen HLA-A heavy
Gene Symbols: HLA-A
Molecular weight: 40,934 Da
Basal Isoelectric point: 5.96  Predict pI for various phosphorylation states
Select Structure to View Below

HLAA iso36

Protein Structure Not Found.


Scansite  |  Pfam  |  ENZYME  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T8-p MAVMAPRtLVLLLSG
0 1 S35 SMRYFFTSVSRPGRG
0 1 R68 DSDAASQRMEPRAPW
0 5 K92 DGETRKVKAHSQTHR
0 2 K151-ub GKDYIALkEDLRSWT
0 3 K170 AAQTTKHKWEAAHVA
0 48 K200-ub RRYLENGkETLQRTD
0 1 K210 LQRTDAPKTHMTHHA
0 5 K267-ub AGDGTFQkWAAVVVP
0 1 Q277 AVVVPSGQEQRYTCH
0 7 K292-ub VQHEGLPkPLTLRWE
1 1 S337-p VMWRRKSsDRkGGsy
0 49 K340-ub RRKSsDRkGGsysQA
1 3 S343-p SsDRkGGsysQAAss
1 24 Y344-p sDRkGGsysQAAssD
0 9 S345-p DRkGGsysQAAssDs
0 2 S349-p GsysQAAssDsAQGs
0 2 S350-p sysQAAssDsAQGsD
0 10 S352-p sQAAssDsAQGsDVs
0 11 S356-p ssDsAQGsDVsLtAC
1 13 S359-p sAQGsDVsLtACkV_
0 5 T361-p QGsDVsLtACkV___
0 38 K364-ub DVsLtACkV______
  HLAA iso3  
T8 MAVMAPRTLLLLLSG
S35 SMRYFFTSVSRPGRG
R68 DSDAASQRMEPRAPW
K92-ub DQETRNVkAQSQTDR
N151 GKDYIALNEDLRSWT
K170 AAQITKRKWEAAHEA
K200-ub RRYLENGkETLQRTD
K210 LQRTDPPKTHMTHHP
K267-ub AGDGTFQkWAAVVVP
E277 AVVVPSGEEQRYTCH
K292 VQHEGLPKPLTLRWE
S337 VMWRRKSSDRkGGsy
K340-ub RRKSSDRkGGsytQA
S343-p SSDRkGGsytQAAsS
Y344-p SDRkGGsytQAAsSD
T345-p DRkGGsytQAAsSDs
S349-p GsytQAAsSDsAQGs
S350 sytQAAsSDsAQGsD
S352-p tQAAsSDsAQGsDVs
S356-p sSDsAQGsDVsLtAC
S359-p sAQGsDVsLtACkV_
T361-p QGsDVsLtACkV___
K364-ub DVsLtACkV______
  HLAA iso24  
T8 MAVMAPRTLVLLLSG
S35 SMRYFSTSVSRPGRG
R68 DSDAASQRMEPRAPW
K92 DEETGKVKAHSQTDR
K151 GKDYIALKEDLRSWT
K170 AAQITKRKWEAAHVA
K200-ub RRYLENGkETLQRTD
K210 LQRTDPPKTHMTHHP
K267-ub AGDGTFQkWAAVVVP
E277 AVVVPSGEEQRYTCH
K292 VQHEGLPKPLTLRWE
S337 VMWRRNSSDRKGGSY
K340 RRNSSDRKGGSYSQA
S343 SSDRKGGSYSQAASS
Y344 SDRKGGSYSQAASSD
S345 DRKGGSYSQAASSDS
S349 GSYSQAASSDSAQGS
S350 SYSQAASSDSAQGSD
S352 SQAASSDSAQGSDVS
S356 SSDSAQGSDVSLTAC
S359 SAQGSDVSLTACKV_
T361 QGSDVSLTACKV___
K364 DVSLTACKV______
  HLAA iso25  
T8 MAVMAPRTLVLLLSG
S35 SMRYFYTSVSRPGRG
R68 DSDAASQRMEPRAPW
K92 DRNTRNVKAHSQTDR
N151 GKDYIALNEDLRSWT
K170-ub AAQITQRkWETAHEA
K200 RRYLENGKETLQRTD
K210 LQRTDAPKTHMTHHA
K267-ub AGDGTFQkWASVVVP
Q277 SVVVPSGQEQRYTCH
K292 VQHEGLPKPLTLRWE
S337-p VMWRRKSsDRkGGsy
K340-ub RRKSsDRkGGsysQA
S343-p SsDRkGGsysQAAss
Y344-p sDRkGGsysQAAssD
S345-p DRkGGsysQAAssDs
S349-p GsysQAAssDsAQGs
S350-p sysQAAssDsAQGsD
S352-p sQAAssDsAQGsDMs
S356-p ssDsAQGsDMsLtAC
S359-p sAQGsDMsLtACkV_
T361-p QGsDMsLtACkV___
K364-ub DMsLtACkV______
  HLAA iso31  
T8 MAVMAPRTLLLLLLG
S35 SMRYFTTSVSRPGRG
R68 DSDAASQRMEPRAPW
K92-ub DQETRNVkAHSQIDR
N151 GKDYIALNEDLRSWT
K170 AAQITQRKWEAARVA
K200 RRYLENGKETLQRTD
K210 LQRTDPPKTHMTHHA
K267-ub AGDGTFQkWASVVVP
Q277 SVVVPSGQEQRYTCH
K292 VQHEGLPKPLTLRWE
S337-p VRWRRKSsDRkGGsy
K340-ub RRKSsDRkGGsysQA
S343-p SsDRkGGsysQAAss
Y344-p sDRkGGsysQAAssD
S345-p DRkGGsysQAAssDs
S349-p GsysQAAssDsAQGs
S350-p sysQAAssDsAQGsD
S352-p sQAAssDsAQGsDMs
S356-p ssDsAQGsDMsLtAC
S359-p sAQGsDMsLtACkV_
T361-p QGsDMsLtACkV___
K364-ub DMsLtACkV______
  HLAA iso36  
T8 MAVMAPRTLLLLLSG
S35 SMRYFFTSVSRPGRG
K68-ub DSDAASQkMEPRAPW
K92-ub DQETRNMkAHSQTDR
N151 GKDYIALNEDLRSWT
K170-ub AAQITKRkWEAVHAA
K200 RRYLENGKETLQRTD
K210 LQRTDPPKTHMTHHP
K267-ub AGDGTFQkWAAVVVP
E277 AVVVPSGEEQRYTCH
K292 VQHEGLPKPLTLRWE
S337 VMWRRKSSDRkGGsy
K340-ub RRKSSDRkGGsytQA
S343-p SSDRkGGsytQAAsS
Y344-p SDRkGGsytQAAsSD
T345-p DRkGGsytQAAsSDs
S349-p GsytQAAsSDsAQGs
S350 sytQAAsSDsAQGsD
S352-p tQAAsSDsAQGsDVs
S356-p sSDsAQGsDVsLtAC
S359-p sAQGsDVsLtACkV_
T361-p QGsDVsLtACkV___
K364-ub DVsLtACkV______
  HLAA iso80  
T8 MAVMPPRTLLLLLSG
S35 SMRYFFTSVSRPGRG
R68 DSDAASQRMEPRAPW
K92 DEETRNVKAHSQTNR
N151 GKDYIALNEDLRSWT
K170 AAQITKRKWEAARRA
K200 RRYLENGKETLQRTD
K210 LQRTDPPKTHMTHHP
K267-ub AGDGTFQkWAAVVVP
K277-ub AVVVPSGkEKRYTCH
E292 VQHEGLPEPLTLRWE
S337 VMWRKKSSVRKGGSY
K340 RKKSSVRKGGSYSQA
S343 SSVRKGGSYSQAASS
Y344 SVRKGGSYSQAASSD
S345 VRKGGSYSQAASSDS
S349 GSYSQAASSDSAQGS
S350 SYSQAASSDSAQGSD
S352 SQAASSDSAQGSDVS
S356 SSDSAQGSDVSLTAC
S359 SAQGSDVSLTACKV_
T361 QGSDVSLTACKV___
K364 DVSLTACKV______
  mouse

 
T8 MGAMAPRTLLLLLAA
S35-p SMRYFETsVSRPGLG
R68 DSDAETPRMEPRAPW
K92-ub ERETQRAkGNEQSFH
N151 GRDYIALNEDLKTWT
K170-ub AAIITRRkWEQAGAA
K200-ub LRYLELGkETLLRTD
K210-ub LLRTDPPkTHVTHHP
K267-ub AGDGTFQkWASVVVP
K277 SVVVPLGKEQNYTCH
E292 VYHEGLPEPLTLRWE
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