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Deptor (human)

Overview Deptor Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes. Note: This description may include information from UniProtKB. Protein type: Apoptosis Cellular Component: intracellular Molecular Function: protein binding Biological Process: regulation of apoptosis; negative regulation of TOR signaling pathway; negative regulation of protein kinase activity; negative regulation of cell size Reference #:  Q8TB45 (UniProtKB) Alt. Names/Synonyms: DEP domain containing 6; DEP domain containing mTOR interacting protein; DEP domain-containing mTOR-interacting protein; DEP domain-containing protein 6; DEP.6; DEPD6; DEPDC6; Deptor; DKFZp564B1778; FLJ12341; FLJ12428; FLJ13854 Gene Symbols: DEPTOR Molecular weight: 46,294 Da Basal Isoelectric point: 8.29  Predict pI for various phosphorylation states CST Pathways:  Insulin Receptor Signaling  |  mTOR Signaling  |  PI3K/Akt Signaling  |  T Cell Receptor Signaling  |  Translation: eIF4E and p70S6K Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Deptor

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	Sites Implicated In
molecular association, regulation: S286‑p, S287‑p, S291‑p, S293‑p, T295‑p, S299‑p protein degradation: S286‑p, S287‑p, S291‑p, T295‑p, S299‑p ubiquitination: S286‑p, S287‑p, S291‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	2		S6-p	__MEEGGstGsAGSD
1	1		T7-p	_MEEGGstGsAGSDS
0	1		S9-p	EEGGstGsAGSDSST
0	2		K58-u	KDRRHHLkTYPNCFV
0	1		K77	IDWLIEHKEASDRET
0	1		K91-u	TAIKLMQkLADRGII
0	3		K142-u	RGQRLYEkLMSPENt
1	0		T149-p	kLMSPENtLLQPREE
0	3		K160-u	PREEEGVkYERTFMA
1	1		S168-p	YERTFMAsEFLDWLV
0	1		K234	LMELLNEKsPsSQET
0	1		K234-u	LMELLNEksPsSQET
1	3		S235-p	MELLNEksPsSQETH
0	1		S237-p	LLNEksPsSQETHDs
0	4		T241	ksPsSQETHDsPFCL
1	12		S244-p	sSQETHDsPFCLRKQ
0	1		S258-p	QSHDNRKstsFMsVs
1	1		T259-p	SHDNRKstsFMsVsP
1	2		S260-p	HDNRKstsFMsVsPs
1	1		S263-p	RKstsFMsVsPsKEI
1	5		S265-p	stsFMsVsPsKEIKI
1	1		S267-p	sFMsVsPsKEIKIVS
0	1		K268	FMsVsPsKEIKIVSA
0	1		K271	VsPsKEIKIVSAVRR
1	5		S279-p	IVSAVRRssMssCGs
2	7		S280-p	VSAVRRssMssCGss
0	3		S282-p	AVRRssMssCGssGY
1	1		S283-p	VRRssMssCGssGYF
3	1		S286-p	ssMssCGssGYFsSs
3	1		S287-p	sMssCGssGYFsSsP
2	0		S291-p	CGssGYFsSsPtLss
0	1		S292	GssGYFsSsPtLsss
2	6		S293-p	ssGYFsSsPtLsssP
2	2		T295-p	GYFsSsPtLsssPPV
2	1		S297-p	FsSsPtLsssPPVLC
2	3		S298-p	sSsPtLsssPPVLCN
2	3		S299-p	SsPtLsssPPVLCNP
0	5		K311-u	CNPKSVLkRPVTSEE
0	5		K348-u	GFVVRGSkPCHIQAV
0	1		T387-p	VLHVDYRtVsNLILT
0	1		S389-p	HVDYRtVsNLILTGP

	mouse
S6	__MEEGSSGGSGSSD
G7	_MEEGSSGGSGSSDS
S9	EEGSSGGSGSSDSNA
K58-u	KDRRHHLkTYPNCFV
K77-u	IDWLIEHkEASDRET
K91	TAIKLMQKLADRGII
K142	RGQRLYEKLMSPETT
T149	KLMSPETTLLQPREE
K160	PREEEGVKYERTFMA
S168	YERTFMASEFLDWLV
T234-p	LMELLNEtsPsSQEt
T234	LMELLNETsPsSQEt
S235-p	MELLNEtsPsSQEtH
S237-p	LLNEtsPsSQEtHDs
T241-p	tsPsSQEtHDsPFCL
S244-p	sSQEtHDsPFCLRKQ
S258-p	QSHDSRKsTsFMSVs
T259	SHDSRKsTsFMSVsP
S260-p	HDSRKsTsFMSVsPs
S263	RKsTsFMSVsPskEI
S265-p	sTsFMSVsPskEIkI
S267-p	sFMSVsPskEIkIVS
K268-u	FMSVsPskEIkIVSA
K271-u	VsPskEIkIVSAVRR
S279-p	IVSAVRRssMssCGS
S280-p	VSAVRRssMssCGSs
S282-p	AVRRssMssCGSsGY
S283-p	VRRssMssCGSsGYF
S286	ssMssCGSsGYFsss
S287-p	sMssCGSsGYFsssP
S291-p	CGSsGYFsssPtLss
S292-p	GSsGYFsssPtLsss
S293-p	SsGYFsssPtLsssP
T295-p	GYFsssPtLsssPPV
S297-p	FsssPtLsssPPVLC
S298-p	sssPtLsssPPVLCN
S299-p	ssPtLsssPPVLCNP
K311-u	CNPKSVLkRPVTSEE
K348	GFVVRGSKPCHIQAV
T387	VLNVDYRTVSNLILT
S389	NVDYRTVSNLILTGP

	rat
A18	LARAEKKAAGSGDVP
A19	ARAEKKAAGSGDVPT
S21	AEKKAAGSGDVPTKR
K165	KDRRHHLKTYPNCFV
K184	IDWLIEHKEASDRET
K198	TAIKLMQKLADRGII
K249	RGQRLYEKLMSPETT
T256	KLMSPETTLLQPREE
K267	PREEEGVKYERTFMA
S275	YERTFMASEFLDWLV
K341	LMELLNEKSPSSQET
K341	LMELLNEKSPSSQET
S342	MELLNEKSPSSQETH
S344	LLNEKSPSSQETHDS
T348	KSPSSQETHDSPFCL
S351	SSQETHDSPFCLRKQ
S365	QSHDNRKSTSFMSVS
T366	SHDNRKSTSFMSVSP
S367	HDNRKSTSFMSVSPS
S370	RKSTSFMSVSPSKEI
S372	STSFMSVSPSKEIKI
S374	SFMSVSPSKEIKIVS
K375	FMSVSPSKEIKIVSA
K378	VSPSKEIKIVSAVRR
S386	IVSAVRRSSMSSCGS
S387	VSAVRRSSMSSCGSS
S389	AVRRSSMSSCGSSGY
S390	VRRSSMSSCGSSGYF
S393	SSMSSCGSSGYFSSS
S394	SMSSCGSSGYFSSSP
S398	CGSSGYFSSSPTLSS
S399	GSSGYFSSSPTLSSS
S400	SSGYFSSSPTLSSSP
T402	GYFSSSPTLSSSPPV
S404	FSSSPTLSSSPPVLC
S405	SSSPTLSSSPPVLCN
S406	SSPTLSSSPPVLCNP
K418	CNPKSVLKRPVTSEE
K455	GFVVRGSKPCHIQAV
T494	VLNVDYRTVSNLILT
S496	NVDYRTVSNLILTGP

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