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Protein Page:
Deptor (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Deptor Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 8q24.12
Cellular Component: intracellular
Molecular Function: protein binding
Biological Process: negative regulation of TOR signaling pathway; negative regulation of protein kinase activity; negative regulation of cell size
Reference #:  Q8TB45 (UniProtKB)
Alt. Names/Synonyms: DEP domain containing 6; DEP domain containing mTOR interacting protein; DEP domain-containing mTOR-interacting protein; DEP domain-containing protein 6; DEP.6; DEPD6; DEPDC6; Deptor; DKFZp564B1778; FLJ12341; FLJ12428; FLJ13854
Gene Symbols: DEPTOR
Molecular weight: 46,294 Da
Basal Isoelectric point: 8.29  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling  |  mTOR Signaling  |  PI3K/Akt Signaling  |  T Cell Receptor Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Deptor

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S286‑p, S287‑p, S291‑p, S293‑p, T295‑p, S299‑p
protein degradation: S286‑p, S287‑p, S291‑p, T295‑p, S299‑p
ubiquitination: S286‑p, S287‑p, S291‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 2 S6-p __MEEGGstGsAGSD
1 1 T7-p _MEEGGstGsAGSDS
0 1 S9-p EEGGstGsAGSDSST
0 2 K58-ub KDRRHHLkTYPNCFV
0 1 K77 IDWLIEHKEASDRET
0 1 K91-ub TAIKLMQkLADRGII
0 3 K142-ub RGQRLYEkLMSPENt
1 0 T149-p kLMSPENtLLQPREE
0 1 K160 PREEEGVKYERTFMA
0 3 K160-ub PREEEGVkYERTFMA
1 1 S168-p YERTFMAsEFLDWLV
0 1 K234 LMELLNEKsPsSQEt
0 1 K234-ub LMELLNEksPsSQEt
1 7 S235-p MELLNEksPsSQEtH
0 2 S237-p LLNEksPsSQEtHDs
0 1 S238 LNEksPsSQEtHDsP
1 4 T241-p ksPsSQEtHDsPFCL
2 17 S244-p sSQEtHDsPFCLRKQ
1 1 S258-p QSHDNRKstsFMsVs
2 1 T259-p SHDNRKstsFMsVsP
1 3 S260-p HDNRKstsFMsVsPs
2 1 S263-p RKstsFMsVsPsKEI
2 10 S265-p stsFMsVsPsKEIKI
1 2 S267-p sFMsVsPsKEIKIVS
0 1 K268 FMsVsPsKEIKIVSA
0 1 K271 VsPsKEIKIVSAVRR
1 5 S279-p IVSAVRRssMssCGs
2 8 S280-p VSAVRRssMssCGss
1 4 S282-p AVRRssMssCGssGY
2 1 S283-p VRRssMssCGssGYF
3 1 S286-p ssMssCGssGYFsSs
4 1 S287-p sMssCGssGYFsSsP
2 0 S291-p CGssGYFsSsPtLss
0 1 S292 GssGYFsSsPtLsss
3 7 S293-p ssGYFsSsPtLsssP
2 3 T295-p GYFsSsPtLsssPPV
3 2 S297-p FsSsPtLsssPPVLC
3 3 S298-p sSsPtLsssPPVLCN
3 4 S299-p SsPtLsssPPVLCNP
0 5 K311-ub CNPKSVLkRPVTSEE
0 5 K348-ub GFVVRGSkPCHIQAV
0 1 T387-p VLHVDYRtVsNLILT
0 1 S389-p HVDYRtVsNLILTGP
  mouse

 
S6 __MEEGSSGGSGSSD
G7 _MEEGSSGGSGSSDS
S9 EEGSSGGSGSSDSNA
K58-ub KDRRHHLkTYPNCFV
K77-ub IDWLIEHkEASDRET
K91 TAIKLMQKLADRGII
K142 RGQRLYEKLMSPETT
T149 KLMSPETTLLQPREE
K160-ac PREEEGVkYERTFMA
K160 PREEEGVKYERTFMA
S168 YERTFMASEFLDWLV
T234-p LMELLNEtsPssQEt
T234 LMELLNETsPssQEt
S235-p MELLNEtsPssQEtH
S237-p LLNEtsPssQEtHDs
S238-p LNEtsPssQEtHDsP
T241-p tsPssQEtHDsPFCL
S244-p ssQEtHDsPFCLRKQ
S258-p QSHDSRKsTsFMSVs
T259 SHDSRKsTsFMSVsP
S260-p HDSRKsTsFMSVsPs
S263 RKsTsFMSVsPskEI
S265-p sTsFMSVsPskEIkI
S267-p sFMSVsPskEIkIVS
K268-ub FMSVsPskEIkIVSA
K271-ub VsPskEIkIVSAVRR
S279-p IVSAVRRssMssCGS
S280-p VSAVRRssMssCGSs
S282-p AVRRssMssCGSsGY
S283-p VRRssMssCGSsGYF
S286 ssMssCGSsGYFsss
S287-p sMssCGSsGYFsssP
S291-p CGSsGYFsssPtLss
S292-p GSsGYFsssPtLsss
S293-p SsGYFsssPtLsssP
T295-p GYFsssPtLsssPPV
S297-p FsssPtLsssPPVLC
S298-p sssPtLsssPPVLCN
S299-p ssPtLsssPPVLCNP
K311-ub CNPKSVLkRPVTSEE
K348 GFVVRGSKPCHIQAV
T387 VLNVDYRTVSNLILT
S389 NVDYRTVSNLILTGP
  rat

 
A18 LARAEKKAAGSGDVP
A19 ARAEKKAAGSGDVPT
S21 AEKKAAGSGDVPTKR
K165 KDRRHHLKTYPNCFV
K184 IDWLIEHKEASDRET
K198 TAIKLMQKLADRGII
K249 RGQRLYEKLMSPETT
T256 KLMSPETTLLQPREE
K267 PREEEGVKYERTFMA
K267 PREEEGVKYERTFMA
S275 YERTFMASEFLDWLV
K341 LMELLNEKSPSSQET
K341 LMELLNEKSPSSQET
S342 MELLNEKSPSSQETH
S344 LLNEKSPSSQETHDs
S345 LNEKSPSSQETHDsP
T348 KSPSSQETHDsPFCL
S351-p SSQETHDsPFCLRKQ
S365 QSHDNRKSTsFMSVs
T366 SHDNRKSTsFMSVsP
S367-p HDNRKSTsFMSVsPs
S370 RKSTsFMSVsPsKEI
S372-p STsFMSVsPsKEIKI
S374-p sFMSVsPsKEIKIVS
K375 FMSVsPsKEIKIVSA
K378 VsPsKEIKIVSAVRR
S386 IVSAVRRSSMSSCGS
S387 VSAVRRSSMSSCGSS
S389 AVRRSSMSSCGSSGY
S390 VRRSSMSSCGSSGYF
S393 SSMSSCGSSGYFSSS
S394 SMSSCGSSGYFSSSP
S398 CGSSGYFSSSPTLSS
S399 GSSGYFSSSPTLSSS
S400 SSGYFSSSPTLSSSP
T402 GYFSSSPTLSSSPPV
S404 FSSSPTLSSSPPVLC
S405 SSSPTLSSSPPVLCN
S406 SSPTLSSSPPVLCNP
K418 CNPKSVLKRPVTSEE
K455 GFVVRGSKPCHIQAV
T494 VLNVDYRTVSNLILT
S496 NVDYRTVSNLILTGP
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