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Protein Page:
CLK3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CLK3 a CMGC kinase of the CLK family. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May play a role in regulating RNA splicing. Three alternatively spliced isoforms have been described. Isoform 2 is short and lacks the kinase domain. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, CMGC; Kinase, protein; EC 2.7.12.1; Protein kinase, dual-specificity (non-receptor); CMGC group; CLK family
Cellular Component: intermediate filament cytoskeleton; membrane; acrosome; nucleolus; nuclear speck; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; protein serine/threonine/tyrosine kinase activity; ATP binding
Biological Process: peptidyl-tyrosine phosphorylation; regulation of RNA splicing; protein amino acid autophosphorylation; protein amino acid phosphorylation
Reference #:  P49761 (UniProtKB)
Alt. Names/Synonyms: CDC-like kinase 3; CLK3; Dual specificity protein kinase CLK3; FLJ22858; PHCLK3; PHCLK3/152
Gene Symbols: CLK3
Molecular weight: 73,515 Da
Basal Isoelectric point: 9.94  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CLK3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 10 Y155-p TMHHCKRyRsPEPDP
1 47 S157-p HHCKRyRsPEPDPyL
0 2 Y163-p RsPEPDPyLsyRWKR
0 3 S165-p PEPDPyLsyRWKRRR
0 1 Y166-p EPDPyLsyRWKRRRS
0 1 Y174-p RWKRRRSysREHEGR
0 2 S175-p WKRRRSysREHEGRL
0 4 S197-p PPPRRSRsRsHDRLP
0 4 S199-p PRRSRsRsHDRLPYQ
0 15 S215-p RYRERRDsDtyRCEE
0 2 T217-p RERRDsDtyRCEERs
0 3 Y218-p ERRDsDtyRCEERsP
0 37 S224-p tyRCEERsPsFGEDY
0 38 S226-p RCEERsPsFGEDYyG
0 1 Y232-p PsFGEDYyGPSRSRH
0 1 S265-p CHKRRTRsCSSAssR
0 1 S270-p TRsCSSAssRSQQSS
0 1 S271-p RsCSSAssRSQQSSK
0 1 S280-p SQQSSKRssRsVEDD
0 3 S281-p QQSSKRssRsVEDDK
0 9 S283-p SSKRssRsVEDDKEG
0 2 T314-p VGNLGEGtFGkVVEC
0 4 K317-ub LGEGtFGkVVECLDH
0 1 K460-ub SCEEKSVkNTSIRVA
0 1 K557-ub RKQKYFYkGGLVWDE
0 2 K573-ub SSDGRYVkENCKPLK
  CLK3 iso1  
- gap
Y7 _MHHCKRYRSPEPDP
S9 HHCKRYRSPEPDPYL
Y15 RSPEPDPYLSYRWKR
S17 PEPDPYLSYRWKRRR
Y18 EPDPYLSYRWKRRRS
Y26 RWKRRRSYSREHEGR
S27 WKRRRSYSREHEGRL
S49 PPPRRSRSRSHDRLP
S51 PRRSRSRSHDRLPYQ
S67 RYRERRDSDTYRCEE
T69 RERRDSDTYRCEERS
Y70 ERRDSDTYRCEERSP
S76 TYRCEERSPSFGEDY
S78 RCEERSPSFGEDYYG
Y84 PSFGEDYYGPSRSRH
S117 CHKRRTRSCSSASSR
S122 TRSCSSASSRSQQSS
S123 RSCSSASSRSQQSSK
S132 SQQSSKRSSRSVEDD
S133 QQSSKRSSRSVEDDK
S135 SSKRSSRSVEDDKEG
T166 VGNLGEGTFGKVVEC
K169 LGEGTFGKVVECLDH
K312 SCEEKSVKNTSIRVA
K409 RKQKYFYKGGLVWDE
K425 SSDGRYVKENCKPLK
  mouse

 
T14-p RRKRLAStAGPRRGS
Y155-p TMHHCKRyRsPEPDP
S157-p HHCKRyRsPEPDPYL
Y163 RsPEPDPYLSYRWKR
S165 PEPDPYLSYRWKRRR
Y166 EPDPYLSYRWKRRRS
Y174-p RWKRRRSySREHEGR
S175 WKRRRSySREHEGRL
S197 PPPRRSRSRSHDRIP
S199 PRRSRSRSHDRIPYQ
S215 RYREHRDSDTYRCEE
T217 REHRDSDTYRCEERs
Y218 EHRDSDTYRCEERsP
S224-p TYRCEERsPsFGEDC
S226-p RCEERsPsFGEDCYG
Y232 PsFGEDCYGSSRSRH
S265 CHKRRTRSCSSASSR
S270 TRSCSSASSRSQQSS
S271 RSCSSASSRSQQSSK
S280 SQQSSKRSsRsVEDD
S281-p QQSSKRSsRsVEDDK
S283-p SSKRSsRsVEDDKEG
T314 VGNLGEGTFGKVVEC
K317 LGEGTFGKVVECLDH
K460 SCEEKSVKNTSIRVA
K557 RKQKYFYKGGLVWDE
K573 SSDGRYVKENCKPLK
  rat

 
- gap
Y7 _MHHCKRYRsPEPDP
S9-p HHCKRYRsPEPDPYL
Y15 RsPEPDPYLSYRWKR
S17 PEPDPYLSYRWKRRR
Y18 EPDPYLSYRWKRRRS
Y26 RWKRRRSYSREHEGR
S27 WKRRRSYSREHEGRL
S49 PPPRRSRSRSHDRIP
S51 PRRSRSRSHDRIPYQ
S67 RYREHRDSDTYRCEE
T69 REHRDSDTYRCEERS
Y70 EHRDSDTYRCEERSP
S76 TYRCEERSPSFGEDC
S78 RCEERSPSFGEDCYG
Y84 PSFGEDCYGSSRSRH
S117 CHKRRTRSCSSASSR
S122 TRSCSSASSRSQQSS
S123 RSCSSASSRSQQSSK
S132 SQQSSKRSSRSVEDD
S133 QQSSKRSSRSVEDDK
S135 SSKRSSRSVEDDKEG
T166 VGNLGEGTFGKVVEC
K169 LGEGTFGKVVECLDH
K312 SCEEKSVKNTSIRVA
K409 RKQKYFYKGGLVWDE
K425 SSDGRYVKENCKPLK
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