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Protein Page:
RXRG (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
RXRG Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Belongs to the nuclear hormone receptor family. NR2 subfamily. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor; DNA binding protein
Cellular Component: nucleoplasm
Molecular Function: protein binding; zinc ion binding; retinoid-X receptor activity; sequence-specific DNA binding; steroid hormone receptor activity
Biological Process: neuron differentiation; transcription initiation from RNA polymerase II promoter; skeletal muscle development; regulation of myelination; response to retinoic acid; heart development; gene expression; positive regulation of transcription from RNA polymerase II promoter; peripheral nervous system development
Reference #:  P48443 (UniProtKB)
Alt. Names/Synonyms: NR2B3; Nuclear receptor subfamily 2 group B member 3; Retinoic acid receptor RXR-gamma; Retinoid X receptor gamma; retinoid X receptor, gamma; retinoid X receptor-gamma; RXRC; RXRG
Gene Symbols: RXRG
Molecular weight: 50,871 Da
Basal Isoelectric point: 7.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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RXRG

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K10-m1 GNYSHFMkFPAGYGG
0 2 Y154-p SGKHYGVySCEGCKG
0 1 K382 VLFNPDAKGLSNPSE
0 2 K418-u EQPGRFAkLLLRLPA
  mouse

 
K10 GNYSHFMKFPTGFGG
Y154 SGKHYGVYSCEGCKG
K382-u VLFNPDAkGLSNPSE
K418-u EQPGRFAkLLLRLPA
  rat

 
K10 GNYSHFMKFPTGFGG
Y154 SGKHYGVYSCEGCKG
K382 VLFNPDAKGLSNPSE
K418 EQPGRFAKLLLRLPA
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