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RXRG (human)

Overview RXRG Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Belongs to the nuclear hormone receptor family. NR2 subfamily. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Nuclear receptor Cellular Component: nucleoplasm Molecular Function: zinc ion binding; retinoid-X receptor activity; sequence-specific DNA binding; steroid hormone receptor activity Biological Process: neuron differentiation; transcription initiation from RNA polymerase II promoter; skeletal muscle development; response to retinoic acid; heart development; gene expression; positive regulation of transcription from RNA polymerase II promoter; peripheral nervous system development Reference #:  P48443 (UniProtKB) Alt. Names/Synonyms: NR2B3; Nuclear receptor subfamily 2 group B member 3; Retinoic acid receptor RXR-gamma; Retinoid X receptor gamma; retinoid X receptor, gamma; retinoid X receptor-gamma; RXRC; RXRG Gene Symbols: RXRG Molecular weight: 50,871 Da Basal Isoelectric point: 7.55  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RXRG 2GL8 - A/B/C/D=227-463 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  Source  |  NURSA  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		Y154-p	SGKHYGVySCEGCKG
0	1		T294-p	IPHFSDLtLEDQVIL
0	1		K382	VLFNPDAKGLSNPSE
0	1		Y398-p	ETLREKVyATLEAyT
0	1		Y404-p	VyATLEAyTKQKYPE
0	2		K418-u	EQPGRFAkLLLRLPA

	mouse
Y154	SGKHYGVYSCEGCKG
T294	IPHFSDLTLEDQVIL
K382-u	VLFNPDAkGLSNPSE
Y398	ETLREKVYATLEAYT
Y404	VYATLEAYTKQKYPE
K418-u	EQPGRFAkLLLRLPA

	rat
Y154	SGKHYGVYSCEGCKG
T294	IPHFSDLTLEDQVIL
K382	VLFNPDAKGLSNPSE
Y398	ETLREKVYATLEAYT
Y404	VYATLEAYTKQKYPE
K418	EQPGRFAKLLLRLPA

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