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Protein Page:
RXRG (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RXRG Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Belongs to the nuclear hormone receptor family. NR2 subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Nuclear receptor
Cellular Component: nucleoplasm
Molecular Function: protein binding; retinoid-X receptor activity; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity
Biological Process: retinoic acid receptor signaling pathway; neuron differentiation; transcription initiation from RNA polymerase II promoter; skeletal muscle development; regulation of myelination; response to retinoic acid; heart development; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; gene expression; peripheral nervous system development
Reference #:  P48443 (UniProtKB)
Alt. Names/Synonyms: NR2B3; Nuclear receptor subfamily 2 group B member 3; Retinoic acid receptor RXR-gamma; Retinoid X receptor gamma; retinoid X receptor, gamma; retinoid X receptor-gamma; RXRC; RXRG
Gene Symbols: RXRG
Molecular weight: 50,871 Da
Basal Isoelectric point: 7.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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RXRG

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K10-m1 GNYSHFMkFPAGYGG
0 2 Y154-p SGKHYGVySCEGCKG
0 1 T294-p IPHFSDLtLEDQVIL
0 1 K382 VLFNPDAKGLSNPSE
0 1 Y398-p ETLREKVyATLEAyT
0 1 Y404-p VyATLEAyTKQKYPE
0 2 K418-ub EQPGRFAkLLLRLPA
  mouse

 
K10 GNYSHFMKFPTGFGG
Y154 SGKHYGVYSCEGCKG
T294 IPHFSDLTLEDQVIL
K382-ub VLFNPDAkGLSNPSE
Y398 ETLREKVYATLEAYT
Y404 VYATLEAYTKQKYPE
K418-ub EQPGRFAkLLLRLPA
  rat

 
K10 GNYSHFMKFPTGFGG
Y154 SGKHYGVYSCEGCKG
T294 IPHFSDLTLEDQVIL
K382 VLFNPDAKGLSNPSE
Y398 ETLREKVYATLEAYT
Y404 VYATLEAYTKQKYPE
K418 EQPGRFAKLLLRLPA
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