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Protein Page:
CDK11B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CDK11B a protein kinase of the CDK family. May act as a negative regulator of the normal cell cycle progression. Nine alternatively spliced isoforms have been described. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform is specifically induced in G2/M phase of the cell cycle. 2 isoforms, SV9 and 7, are produced by alternative initiation at Met-1 and Met-357 resulting in p110 and p58 isoforms, respectively. Deleted or altered frequently in neuroblastoma with amplified MYCN genes. Can be cleaved by caspases and demonstrated to play a role in cell apoptosis. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Kinase, protein; EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; Apoptosis; CMGC group; CDK family; PITSLRE subfamily; CDK/PITSLRE subfamily
Cellular Component: cytoplasm; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; cyclin-dependent protein kinase activity; ATP binding; protein kinase activity
Biological Process: cell proliferation; mitosis; regulation of transcription, DNA-dependent; apoptosis; regulation of cell cycle; regulation of cell growth; protein amino acid phosphorylation; regulation of mRNA processing
Reference #:  P21127 (UniProtKB)
Alt. Names/Synonyms: CD11B; CDC-related protein kinase p58; CDC2L1; CDC2L2; CDK11; CDK11-p110; CDK11-p46; CDK11-p58; CDK11B; CDK11p58; cell division cycle 2-like 1 (PITSLRE proteins); cell division cycle 2-like 2 (PITSLRE proteins); cell division cycle 2-like protein kinase 1; cell division protein kinase 11B; CLK-1; cyclin-dependent kinase 11B; FLJ59152; galactosyltransferase-associated protein kinase p58/GTA; p58; p58 CLK-1; p58CDC2L1; p58CLK-1; PITSLRE; PITSLRE serine/threonine-protein kinase CDC2L1; PITSLREA; PK58
Gene Symbols: CDK11B
Molecular weight: 92,707 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CDK11B

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S115‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S43 KNSDDRDSKRDsLEE
1 26 S47-p DRDSKRDsLEEGELR
0 3 T61-p RDHRMEItIRNsPyR
0 19 S65-p MEItIRNsPyRREDs
0 2 Y67-p ItIRNsPyRREDsME
0 9 S72-p sPyRREDsMEDRGEE
0 1 K101-ac KEKVHHRkDEKRKEK
0 4 S113-p KEKRRHRsHsAEGGK
1 4 S115-p KRRHRsHsAEGGKHA
0 1 K135-ac EREHERRkRHREEQD
0 8 Y222-p HRTMREDySDKVKAS
0 2 S232-p KVKASHWsRsPPRPP
1 14 S234-p KASHWsRsPPRPPRE
0 15 S277-p MEERDLLsDLQDIsD
1 46 S283-p LsDLQDIsDsERKTS
1 4 S285-p DLQDIsDsERKTSSA
0 3 S381-p ESRFDRDsGEsEEAE
0 2 S384-p FDRDsGEsEEAEEEV
0 1 T395-p EEEVGEGtPQSSALT
0 1 D405-ca SSALTEGdyVPDsPA
0 1 Y406-p SALTEGdyVPDsPAL
0 4 S410-p EGdyVPDsPALsPIE
0 4 S414-p VPDsPALsPIELKQE
0 7 Y453-p EGTYGVVyRAkDkkT
0 1 K456-ac YGVVyRAkDkkTDEI
0 1 K458-ac VVyRAkDkkTDEIVA
0 1 K459-ac VyRAkDkkTDEIVAL
0 8 K467-ac TDEIVALkRLKMEKE
0 4 K467-ub TDEIVALkRLKMEKE
0 1 K564 WILHRDLKTSNLLLS
0 15 K577-ub LSHAGILkVGDFGLA
0 8 Y587-p DFGLAREyGsPLKAy
0 54 S589-p GLAREyGsPLKAytP
0 9 Y594-p yGsPLKAytPVVVtL
1 67 T595-p GsPLKAytPVVVtLW
0 2 T600-p AytPVVVtLWYRAPE
0 1 K641 QKPLFPGKSEIDQIN
0 1 K649 SEIDQINKVFKDLGT
0 5 K660-ub DLGTPSEkIWPGYSE
0 1 K672-ub YSELPAVkKMTFSEH
0 1 K673 SELPAVkKMTFSEHP
0 2 K719-ub ISAEDGLkHEYFRET
1 0 T726 kHEYFRETPLPIDPS
0 2 K741-ub MFPTWPAkSEQQRVK
1 37 T751-p QQRVKRGtsPRPPEG
1 36 S752-p QRVKRGtsPRPPEGG
1 5 Y762-p PPEGGLGysQLGDDD
1 9 S763-p PEGGLGysQLGDDDL
0 1 T773-p GDDDLKEtGFHLTTT
  CDK11B iso9  
S9-p SQSDDRDsKRDSLEE
S13 DRDsKRDSLEEGELR
T27 RDHRMEITIRNSPYR
S31 MEITIRNSPYRREDS
Y33 ITIRNSPYRREDSME
S38 SPYRREDSMEDRGEE
K67 KEKVHHRKDEKRKEK
S79 KEKRRHRSHSAEGGK
S81 KRRHRSHSAEGGKHA
K101 EREHERRKRHREEQD
Y188 HRTMREDYSDKVKAS
S198 KVKASHWSRSPPRPP
S200 KASHWSRSPPRPPRE
S230 MEERDLLSDLQDISD
S236 LSDLQDISDSERKTS
S238 DLQDISDSERKTSSA
S334 ESRFDRDSGESEEAE
S337 FDRDSGESEEAEEEV
T348 EEEVGEGTPQSSALT
D358 SSALTEGDYVPDSPA
Y359 SALTEGDYVPDSPAL
S363 EGDYVPDSPALSPIE
S367 VPDSPALSPIELKQE
Y406 EGTYGVVYRAKDKKT
K409 YGVVYRAKDKKTDEI
K411 VVYRAKDKKTDEIVA
K412 VYRAKDKKTDEIVAL
K420 TDEIVALKRLKMEKE
K420 TDEIVALKRLKMEKE
K517 WILHRDLKTSNLLLS
K530 LSHAGILKVGDFGLA
Y540 DFGLAREYGSPLKAY
S542 GLAREYGSPLKAYTP
Y547 YGSPLKAYTPVVVTL
T548 GSPLKAYTPVVVTLW
T553 AYTPVVVTLWYRAPE
K594 QKPLFPGKSEIDQIN
K602 SEIDQINKVFKDLGT
K613 DLGTPSEKIWPGYSE
K625 YSELPAVKKMTFSEH
K626 SELPAVKKMTFSEHP
K672 ISAEDGLKHEYFRET
T679 KHEYFRETPLPIDPS
K694 MFPTWPAKSEQQRVK
T704 QQRVKRGTSPRPPEG
S705 QRVKRGTSPRPPEGG
Y715 PPEGGLGYSQLGDDD
S716 PEGGLGYSQLGDDDL
T726 GDDDLKETGFHLTTT
  CDK11B iso12  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S25 ESRFDRDSGESEEAE
S28 FDRDSGESEEAEEEV
T39 EEEVGEGTPQSSALT
D49 SSALTEGDYVPDSPA
Y50 SALTEGDYVPDSPAL
S54 EGDYVPDSPALSPIE
S58 VPDSPALSPIELKQE
Y97 EGTYGVVYRAKDKKT
K100 YGVVYRAKDKKTDEI
K102 VVYRAKDKKTDEIVA
K103 VYRAKDKKTDEIVAL
K111 TDEIVALKRLKMEKE
K111 TDEIVALKRLKMEKE
K208 WILHRDLKTSNLLLS
K221 LSHAGILKVGDFGLA
Y231 DFGLAREYGSPLKAY
S233 GLAREYGSPLKAYTP
Y238 YGSPLKAYTPVVVTL
T239 GSPLKAYTPVVVTLW
T244 AYTPVVVTLWYRAPE
K285 QKPLFPGKSEIDQIN
K293 SEIDQINKVFKDLGT
K304 DLGTPSEKIWPGYSE
K316 YSELPAVKKMTFSEH
K317 SELPAVKKMTFSEHP
K363 ISAEDGLKHEYFREt
T370-p KHEYFREtPLPIDPS
K385 MFPTWPAKSEQQRVK
T395 QQRVKRGTSPRPPEG
S396 QRVKRGTSPRPPEGG
Y406 PPEGGLGYSQLGDDD
S407 PEGGLGYSQLGDDDL
T417 GDDDLKETGFHLTTT
  mouse

 
S43 KNSDDRDSKRDsLEE
S47-p DRDSKRDsLEEGELR
T61 RDHRMEITIRNsPyR
S65-p MEITIRNsPyRREDs
Y67-p ITIRNsPyRREDsME
S72-p sPyRREDsMEDRGEE
K101 KEKAHHRKDEKRKEK
S113-p KEKRRHRsHsAEGGK
S115-p KRRHRsHsAEGGKHA
K135 EREHERRKRHREEQD
Y222 HRTMREEYSDKGKVG
S232-p KGKVGHWsRsPLRPP
S234-p KVGHWsRsPLRPPRE
S264-p VEERDLLsDLQDIsD
S270-p LsDLQDIsDSERKTS
S272 DLQDIsDSERKTSSA
S370 ESRFDRDSGDSEEGE
S373 FDRDSGDSEEGEEEV
T384 EEEVGEGTPQSSAPT
D394 SSAPTEGDYVPDSPA
Y395 SAPTEGDYVPDSPAL
S399 EGDYVPDSPALSPIE
S403 VPDSPALSPIELKQE
Y442 EGTYGVVYRAKDKKT
K445 YGVVYRAKDKKTDEI
K447 VVYRAKDKKTDEIVA
K448 VYRAKDKKTDEIVAL
K456 TDEIVALKRLKMEKE
K456 TDEIVALKRLKMEKE
K553-ub WILHRDLkTSNLLLS
K566 LSHAGILKVGDFGLA
Y576-p DFGLAREyGsPLKAy
S578-p GLAREyGsPLKAytP
Y583-p yGsPLKAytPVVVTL
T584-p GsPLKAytPVVVTLW
T589 AytPVVVTLWYRAPE
K630-ub QKPLFPGkSDIDQIN
K638-ub SDIDQINkIFKDLGT
K649-ub DLGTPSEkIWPGYND
K661 YNDLPAVKkMTFSEY
K662-ub NDLPAVKkMTFSEYP
K708 INAEDGLKHEYFRET
T715 KHEYFRETPLPIDPS
K730 MFPTWPAKSEQQRVK
T740-p QQRVKRGtsPRPPEG
S741-p QRVKRGtsPRPPEGG
Y751-p PPEGGLGysQLGDDD
S752-p PEGGLGysQLGDDDL
T762-p GDDDLKEtGFHLTTT
  rat

► Hide Isoforms
 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
L22 SHEVTEILGRVKKNR
V25 VTEILGRVKKNRKKL
L36 RKKLVKGLHRAGPPP
N46 AGPPPEKNYLPDSPA
Y47 GPPPEKNYLPDSPAL
S51 EKNYLPDSPALSPIE
S55 LPDSPALSPIELKQE
Y94 EGTYGVVYRAKDKKT
K97 YGVVYRAKDKKTDEI
K99 VVYRAKDKKTDEIVA
K100 VYRAKDKKTDEIVAL
K108 TDEIVALKRLKMEKE
K108 TDEIVALKRLKMEKE
K205 WILHRDLKTSNLLLT
K218 LTHAGILKVGDFGLA
Y228 DFGLAREYGsPLKAY
S230-p GLAREYGsPLKAYtP
Y235 YGsPLKAYtPVVVTL
T236-p GsPLKAYtPVVVTLW
T241 AYtPVVVTLWYRAPE
K282 QKPLFPGKSDIDQIN
K290 SDIDQINKIFKDIGT
K301 DIGTPSEKIWPGYSE
K313 YSELPAVKKMTFSEL
K314 SELPAVKKMTFSELP
K360 INAEDGLKHEYFRET
T367 KHEYFRETPLPIDPS
K382 MFPTWPAKSEQQCVK
T392 QQCVKRGTSPKPPEG
S393 QCVKRGTSPKPPEGG
Y403 PPEGGLGYSQLGDDD
S404 PEGGLGYSQLGDDDL
T414 GDDDLKETGFHLTTT
  CDK11B iso12  
S43 KNSDDRDSKRDsLEE
S47-p DRDSKRDsLEEGELR
T61 RDHRMEITIRNSPYR
S65 MEITIRNSPYRREDS
Y67 ITIRNSPYRREDSME
S72 SPYRREDSMEDRGEE
K101 KEKAHHRKDEKRKEK
S113 KEKRRHRSHSAEGGK
S115 KRRHRSHSAEGGKHA
K135 EREHERRKRHREEQD
Y222 HRTMREDYSDKGKVG
S232 KGKVGHWSRSPLRPP
S234 KVGHWSRSPLRPPRE
S264-p VEERDLLsDLQDIsD
S270-p LsDLQDIsDSERKTS
S272 DLQDIsDSERKTSSA
S370 ESRFDRDSGDSDEGE
S373 FDRDSGDSDEGEEEV
T384 EEEVGEGTPQSSAPT
D394 SSAPTEGDYVPDSPA
Y395 SAPTEGDYVPDSPAL
S399 EGDYVPDSPALSPIE
S403 VPDSPALSPIELKQE
Y442 EGTYGVVYRAKDKKT
K445 YGVVYRAKDKKTDEI
K447 VVYRAKDKKTDEIVA
K448 VYRAKDKKTDEIVAL
K456 TDEIVALKRLKMEKE
K456 TDEIVALKRLKMEKE
K553 WILHRDLKTSNLLLS
K566 LSHAGILKVGDFGLA
Y576 DFGLAREYGSPLKAY
S578 GLAREYGSPLKAYTP
Y583 YGSPLKAYTPVVVTL
T584 GSPLKAYTPVVVTLW
T589 AYTPVVVTLWYRAPE
K630 QKPLFPGKSEIDQIN
K638 SEIDQINKVFKDLGT
K649 DLGTPSEKIWPGYND
K661 YNDLPAVKKMTFSEY
K662 NDLPAVKKMTFSEYP
K708 VSAEDGLKHEYFRET
T715 KHEYFRETPLPIDSS
K730 MFPTWPAKSEQQRVK
T740 QQRVKRGTSPRPPEG
S741 QRVKRGTSPRPPEGG
Y751 PPEGGLGYSQLGDDD
S752 PEGGLGYSQLGDDDL
T762 GDDDLKETGFHLTTT
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