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Protein Page:
CDK12 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CDK12 a Ser/Thr protein kinase of the CMGC group and CDK family. Phosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Interacts with CCNL1 and CCNL2. Colocalized with nuclear speckles throughout interphase. Has a highly phosphorylated arginine/serine-rich (RS) domain N-terminal to the kinase domain. Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not in-frame with ERBB2. Three isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; Kinase, protein; Motility/polarity/chemotaxis; EC 2.7.11.22; EC 2.7.11.23; CMGC group; CDK family; CRK7 subfamily; CDK/CRK7 subfamily
Cellular Component: nuclear cyclin-dependent protein kinase holoenzyme complex; nucleolus; nuclear speck; nucleus
Molecular Function: RNA polymerase subunit kinase activity; cyclin binding; protein binding; cyclin-dependent protein kinase activity; ATP binding; protein kinase activity
Biological Process: protein amino acid autophosphorylation; RNA splicing; regulation of MAP kinase activity; mRNA processing
Reference #:  Q9NYV4 (UniProtKB)
Alt. Names/Synonyms: Cdc2-related kinase, arginine/serine-rich; CDC2-related protein kinase 7; CDK12; Cell division cycle 2-related protein kinase 7; Cell division protein kinase 12; CRK7; CRKR; CRKRS; cyclin-dependent kinase 12; KIAA0904
Gene Symbols: CDK12
Molecular weight: 164,155 Da
Basal Isoelectric point: 9.46  Predict pI for various phosphorylation states
Select Structure to View Below

CDK12
Protein Structure Not Found.


STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 1 S14 HGGKKDGSGGASGTL
0 1 S18 KDGSGGASGTLQPss
0 1 S24-p ASGTLQPssGGGSSN
0 1 S25-p SGTLQPssGGGSSNs
0 3 S32-p sGGGSSNsRERHRLV
0 3 T57-p SKDMGLVtPEAASLG
0 1 S62 LVtPEAASLGTVIKP
0 1 T65 PEAASLGTVIKPLVE
0 1 Y73-p VIKPLVEyDDIssDs
0 1 S77-p LVEyDDIssDsDTFs
0 1 S78-p VEyDDIssDsDTFsD
0 1 S80-p yDDIssDsDTFsDDM
0 2 S84-p ssDsDTFsDDMAFKL
0 1 T158-p SKRSNEEtDDyGKAQ
0 9 Y161-p SNEEtDDyGKAQVAK
0 1 S176-p SSSKESRssKLHKEK
0 1 S177-p SSKESRssKLHKEKT
0 1 K203-a DRSKSHRkRETPKSY
0 1 K211-a RETPKSYkTVDsPKR
0 1 S215-p KSYkTVDsPKRRSRS
0 2 S228-p RSPHRKWsDSSKQDD
0 1 S230 PHRKWsDSSKQDDsP
0 11 S236-p DSSKQDDsPsGASYG
0 3 S238-p SKQDDsPsGASYGQD
0 2 Y246-p GASYGQDyDLsPsRS
0 14 S249-p YGQDyDLsPsRSHts
0 1 S251-p QDyDLsPsRSHtssN
0 1 T255-p LsPsRSHtssNYDsY
0 2 S256-p sPsRSHtssNYDsYK
0 1 S257-p PsRSHtssNYDsYKK
0 1 S261-p HtssNYDsYKKsPGS
0 8 S265-p NYDsYKKsPGSTSRR
0 1 S270 KKsPGSTSRRQsVsP
0 69 S274-p GSTSRRQsVsPPyKE
0 48 S276-p TSRRQsVsPPyKEPs
0 19 Y279-p RQsVsPPyKEPsAyQ
0 2 S283-p sPPyKEPsAyQssTR
0 3 Y285-p PyKEPsAyQssTRsP
0 4 S287-p KEPsAyQssTRsPsP
0 2 S288-p EPsAyQssTRsPsPY
0 14 S291-p AyQssTRsPsPYSRR
0 19 S293-p QssTRsPsPYSRRQR
0 32 S301-p PYSRRQRsVsPysRR
0 31 S303-p SRRQRsVsPysRRRs
0 4 Y305-p RQRsVsPysRRRsss
0 2 S306-p QRsVsPysRRRsssY
0 7 S310-p sPysRRRsssYERSG
0 6 S311-p PysRRRsssYERSGs
0 6 S312-p ysRRRsssYERSGsy
0 20 S318-p ssYERSGsysGRsPs
0 23 Y319-p sYERSGsysGRsPsP
0 4 S320-p YERSGsysGRsPsPy
0 66 S323-p SGsysGRsPsPyGrr
0 69 S325-p sysGRsPsPyGrrrs
0 6 Y327-p sGRsPsPyGrrrsss
0 1 R329-m2 RsPsPyGrrrsssPF
0 1 R330-m2 sPsPyGrrrsssPFL
0 1 R331-m2 PsPyGrrrsssPFLs
0 57 S332-p sPyGrrrsssPFLsK
0 28 S333-p PyGrrrsssPFLsKR
0 48 S334-p yGrrrsssPFLsKRs
0 9 S338-p rsssPFLsKRsLsRs
0 10 S341-p sPFLsKRsLsRsPLP
0 11 S343-p FLsKRsLsRsPLPsR
0 12 S345-p sKRsLsRsPLPsRKS
0 1 S349-p LsRsPLPsRKSMKsR
0 4 S355-p PsRKSMKsRsRsPAy
0 3 S357-p RKSMKsRsRsPAysR
0 3 S359-p SMKsRsRsPAysRHS
0 1 Y362-p sRsRsPAysRHSSSH
0 2 S363-p RsRsPAysRHSSSHS
0 9 S382-p SSSRSRHssIsPVRL
0 113 S383-p SSRSRHssIsPVRLP
0 119 S385-p RSRHssIsPVRLPLN
0 6 S393-p PVRLPLNssLGAELs
0 3 S394-p VRLPLNssLGAELsR
0 4 S400-p ssLGAELsRKKKERA
0 2 S420-p AKMDGKEsKGsPVFL
0 15 S423-p DGKEsKGsPVFLPRK
0 1 S434-p LPRKENSsVEAKDSG
0 1 R449-m2 LESKKLPrSVKLEKs
0 1 S456-p rSVKLEKsAPDTELV
0 2 K504-a AQGTRDSkPIALkEE
0 2 K509-a DSkPIALkEEIVtPK
0 2 T514-p ALkEEIVtPKETEts
0 1 T520-p VtPKETEtsEKETPP
0 1 S521-p tPKETEtsEKETPPP
0 1 T592-g PPSTHSKtSAVSsQA
0 1 S593 PSTHSKtSAVSsQAN
0 1 S597-g SKtSAVSsQANSQPP
0 1 A599 tSAVSsQANSQPPVQ
0 2 S644-p PGDDDMDsPKETLPS
0 1 T648 DMDsPKETLPSKPVK
0 1 S651 sPKETLPSKPVKKEK
0 41 S681-p ELPGGDLsPPDsPEP
0 41 S685-p GDLsPPDsPEPKAIt
0 15 T692-p sPEPKAItPPQQPYK
0 1 S886-p GLARLYNsEEsRPYt
0 2 S889-p RLYNsEEsRPYtNKV
0 1 Y892 NsEEsRPYtNKVITL
0 44 T893-p sEEsRPYtNKVITLW
0 1 S991 EEFSFIPSAALDLLD
0 2 T1002-p DLLDHMLtLDPsKRC
0 2 S1006-p HMLtLDPsKRCTAEQ
0 1 T1010 LDPsKRCTAEQTLQS
0 2 S1053-p KRRRQRQsGVVVEEP
0 1 S1063-p VVEEPPPsKTsRKEt
0 1 S1066-p EPPPsKTsRKEttSG
0 1 T1070-p sKTsRKEttSGTSTE
0 1 T1071-p KTsRKEttSGTSTEP
0 1 S1082-p STEPVKNssPAPPQP
0 27 S1083-p TEPVKNssPAPPQPA
0 30 T1244-p GPQGPRRtPTMPQEE
0 4 T1246 QGPRRtPTMPQEEAA
0 1 T1363 RNSGPALTESLVQTL
0 1 S1365 SGPALTESLVQTLVK
0 3 T1369 LTESLVQTLVKNRtF
0 6 T1375-p QTLVKNRtFSGSLSH
0 1 S1387-p LSHLGESsSYQGTGS
0 3 R1404-m1 FPGDQDLrFARVPLA
0 1 K1470-a TQSSAYGkLYRGPTR
  CDK12 iso2  
S14 HGGKKDGSGGASGTL
S18 KDGSGGASGTLQPSS
S24 ASGTLQPSSGGGSSN
S25 SGTLQPSSGGGSSNS
S32 SGGGSSNSRERHRLV
T57 SKDMGLVTPEAASLG
S62 LVTPEAASLGTVIKP
T65 PEAASLGTVIKPLVE
Y73 VIKPLVEYDDISSDS
S77 LVEYDDISSDSDTFS
S78 VEYDDISSDSDTFSD
S80 YDDISSDSDTFSDDM
S84 SSDSDTFSDDMAFKL
T158 SKRSNEETDDYGKAQ
Y161 SNEETDDYGKAQVAK
S176 SSSKESRSSKLHKEK
S177 SSKESRSSKLHKEKT
K203 DRSKSHRKRETPKSY
K211 RETPKSYKTVDSPKR
S215 KSYKTVDSPKRRSRS
S228 RSPHRKWSDSSKQDD
S230 PHRKWSDSSKQDDSP
S236 DSSKQDDSPSGASYG
S238 SKQDDSPSGASYGQD
Y246 GASYGQDYDLSPSRS
S249 YGQDYDLSPSRSHTS
S251 QDYDLSPSRSHTSSN
T255 LSPSRSHTSSNYDSY
S256 SPSRSHTSSNYDSYK
S257 PSRSHTSSNYDSYKK
S261 HTSSNYDSYKKSPGS
S265 NYDSYKKSPGSTSRR
S270 KKSPGSTSRRQSVSP
S274 GSTSRRQSVSPPYKE
S276 TSRRQSVSPPYKEPS
Y279 RQSVSPPYKEPSAYQ
S283 SPPYKEPSAYQSSTR
Y285 PYKEPSAYQSSTRSP
S287 KEPSAYQSSTRSPSP
S288 EPSAYQSSTRSPSPY
S291 AYQSSTRSPSPYSRR
S293 QSSTRSPSPYSRRQR
S301 PYSRRQRSVSPYSRR
S303 SRRQRSVSPYSRRRS
Y305 RQRSVSPYSRRRSSS
S306 QRSVSPYSRRRSSSY
S310 SPYSRRRSSSYERSG
S311 PYSRRRSSSYERSGS
S312 YSRRRSSSYERSGSY
S318 SSYERSGSYSGRSPS
Y319 SYERSGSYSGRSPSP
S320 YERSGSYSGRSPSPY
S323 SGSYSGRSPSPYGRR
S325 SYSGRSPSPYGRRRs
Y327 SGRSPSPYGRRRssS
R329 RSPSPYGRRRssSPF
R330 SPSPYGRRRssSPFL
R331 PSPYGRRRssSPFLS
S332-p SPYGRRRssSPFLSK
S333-p PYGRRRssSPFLSKR
S334 YGRRRssSPFLSKRS
S338 RssSPFLSKRSLSRS
S341 SPFLSKRSLSRSPLP
S343 FLSKRSLSRSPLPSR
S345 SKRSLSRSPLPSRKS
S349 LSRSPLPSRKSMKSR
S355 PSRKSMKSRSRSPAY
S357 RKSMKSRSRSPAYSR
S359 SMKSRSRSPAYSRHS
Y362 SRSRSPAYSRHSSSH
S363 RSRSPAYSRHSSSHS
S382 SSSRSRHSsIsPVRL
S383-p SSRSRHSsIsPVRLP
S385-p RSRHSsIsPVRLPLN
S393 PVRLPLNSSLGAELS
S394 VRLPLNSSLGAELSR
S400 SSLGAELSRKKKERA
S420 AKMDGKESKGSPVFL
S423 DGKESKGSPVFLPRK
S434 LPRKENSSVEAKDSG
R449 LESKKLPRSVKLEKS
S456 RSVKLEKSAPDTELV
K504 AQGTRDSKPIALKEE
K509 DSKPIALKEEIVTPK
T514 ALKEEIVTPKETETS
T520 VTPKETETSEKETPP
S521 TPKETETSEKETPPP
T592 PPSTHSKTSAVSSQA
S593 PSTHSKTSAVSSQAN
S597 SKTSAVSSQANSQPP
A599 TSAVSSQANSQPPVQ
S644 PGDDDMDSPKETLPS
T648 DMDSPKETLPSKPVK
S651 SPKETLPSKPVKKEK
S681 ELPGGDLSPPDSPEP
S685 GDLSPPDSPEPKAIT
T692 SPEPKAITPPQQPYK
S886 GLARLYNSEESRPYT
S889 RLYNSEESRPYTNKV
Y892 NSEESRPYTNKVITL
T893 SEESRPYTNKVITLW
S991 EEFSFIPSAALDLLD
T1002 DLLDHMLTLDPSKRC
S1006 HMLTLDPSKRCTAEQ
T1010 LDPSKRCTAEQTLQS
S1053 KRRRQRQSGVVVEEP
S1063 VVEEPPPSKTSRKET
S1066 EPPPSKTSRKETTSG
T1070 SKTSRKETTSGTSTE
T1071 KTSRKETTSGTSTEP
S1082 STEPVKNSSPAPPQP
S1083 TEPVKNSSPAPPQPA
T1244-p GPQGPRRtPtMPQEE
T1246-p QGPRRtPtMPQEEAA
T1354 RNSGPALTESLVQTL
S1356 SGPALTESLVQTLVK
T1360 LTESLVQTLVKNRTF
T1366 QTLVKNRTFSGSLSH
S1378 LSHLGESSSYQGTGS
R1395 FPGDQDLRFARVPLA
K1461 TQSSAYGKLYRGPTR
  mouse

► Hide Isoforms 		 
S14-p HGGKKDGsGGAsGTS
S18-p KDGsGGAsGTSQPSS
S24 AsGTSQPSSGGGSSN
S25 sGTSQPSSGGGSSNs
S32-p SGGGSSNsRERHRLV
T57-p SKDVGLVtPEAASLG
S62 LVtPEAASLGTIIKP
T65 PEAASLGTIIKPLVE
Y73 IIKPLVEYDDISSDS
S77 LVEYDDISSDSDTFS
S78 VEYDDISSDSDTFSD
S80 YDDISSDSDTFSDDT
S84 SSDSDTFSDDTAFKS
S157 SKRSVEGSDDYGKAQ
Y160 SVEGSDDYGKAQLSK
S175 SGSKESRSSKMHKEK
S176 GSKESRSSKMHKEKT
K202 DRSKSHRKRETPKSY
K210 RETPKSYKTVASPKR
S214 KSYKTVASPKRRSRS
S227-p RSPHRKWsDsSKQDD
S229-p PHRKWsDsSKQDDsP
S235-p DsSKQDDsPsGASYG
S237-p SKQDDsPsGASYGQD
Y245-p GASYGQDyDLsPPRS
S248-p YGQDyDLsPPRSHTS
P250 QDyDLsPPRSHTSSN
T254 LsPPRSHTSSNYDSY
S255 sPPRSHTSSNYDSYK
S256 PPRSHTSSNYDSYKK
S260 HTSSNYDSYKKSPGS
S264 NYDSYKKSPGSTsRR
S269-p KKSPGSTsRRQsIsP
S273-p GSTsRRQsIsPPyKE
S275-p TsRRQsIsPPyKEPS
Y278-p RQsIsPPyKEPSAYQ
S282 sPPyKEPSAYQSSTR
Y284 PyKEPSAYQSSTRsP
S286 KEPSAYQSSTRsPsP
S287 EPSAYQSSTRsPsPY
S290-p AYQSSTRsPsPYSRR
S292-p QSSTRsPsPYSRRQR
S300-p PYSRRQRsVsPySRR
S302-p SRRQRsVsPySRRRs
Y304-p RQRsVsPySRRRsss
S305 QRsVsPySRRRsssY
S309-p sPySRRRsssYERSG
S310-p PySRRRsssYERSGs
S311-p ySRRRsssYERSGsy
S317-p ssYERSGsysGRsPs
Y318-p sYERSGsysGRsPsP
S319-p YERSGsysGRsPsPy
S322-p SGsysGRsPsPyGRR
S324-p sysGRsPsPyGRRRs
Y326-p sGRsPsPyGRRRsss
R328 RsPsPyGRRRsssPF
R329 sPsPyGRRRsssPFL
R330 PsPyGRRRsssPFLs
S331-p sPyGRRRsssPFLsK
S332-p PyGRRRsssPFLsKR
S333-p yGRRRsssPFLsKRs
S337-p RsssPFLsKRsLsRs
S340-p sPFLsKRsLsRsPLP
S342-p FLsKRsLsRsPLPSR
S344-p sKRsLsRsPLPSRKS
S348 LsRsPLPSRKSMKsR
S354-p PSRKSMKsRsRsPAY
S356-p RKSMKsRsRsPAYSR
S358-p SMKsRsRsPAYSRHS
Y361 sRsRsPAYSRHSSSH
S362 RsRsPAYSRHSSSHS
S381-p SGSRSRHssIsPVRL
S382-p GSRSRHssIsPVRLP
S384-p RSRHssIsPVRLPLN
S392-p PVRLPLNssLGAELS
S393-p VRLPLNssLGAELSR
S399 ssLGAELSRKKKERA
S419 AKMDGKESKSsPIIL
S422-p DGKESKSsPIILPKK
K431 IILPKKEKLEVKESG
R446 LESKKLPRSIKSEKs
S453-p RSIKSEKsTPDTELV
K501 AQGTKDVKPVAPKEV
K506 DVKPVAPKEVIVTSK
T511 APKEVIVTSKETETS
T517 VTSKETETSEKETLP
S518 TSKETETSEKETLPP
T588 PSSPHPRTsTLSSQt
S589-g SSPHPRTsTLSSQtN
S593 PRTsTLSSQtNSQPP
T595-p TsTLSSQtNSQPPVQ
S640-p PGDDDMDsPKEtLPs
T644-p DMDsPKEtLPsKPAK
S647-p sPKEtLPsKPAKKEK
S677-p ELPGGDPsPPDsPEP
S681-p GDPsPPDsPEPKAIt
T688-p sPEPKAItPPQQPYK
S882 GLARLYNSEESRPyt
S885 RLYNSEESRPytNKV
Y888-p NSEESRPytNKVITL
T889-p SEESRPytNKVITLW
S987-p EEFSFIPsAALDLLD
T998 DLLDHMLTLDPSKRC
S1002 HMLTLDPSKRCtAEQ
T1006-p LDPSKRCtAEQTLQS
S1049 KRRRQRQSGIVIEDP
S1059 VIEDPPPSKASRKET
S1062 DPPPSKASRKETTSG
T1066 SKASRKETTSGTTAE
T1067 KASRKETTSGTTAEP
N1078 TAEPVKNNsPAPPQP
S1079-p AEPVKNNsPAPPQPA
T1240-p GPQGPRRtPtMPQEE
T1242-p QGPRRtPtMPQEEAA
T1359-g RSSGPALtEsLVQtP
S1361-p SGPALtEsLVQtPVK
T1365-p LtEsLVQtPVKNRTF
T1371 QtPVKNRTFSGSVSH
N1383 VSHLGESNSYQGTGS
R1400 FPGDQDLRFTRVPLA
K1464 GPAQSYGKPYRGAAR
  CDK12 iso3  
S14 HGGKKDGSGGASGTS
S18 KDGSGGASGTSQPSS
S24 ASGTSQPSSGGGSSN
S25 SGTSQPSSGGGSSNS
S32 SGGGSSNSRERHRLV
T57 SKDVGLVTPEAASLG
S62 LVTPEAASLGTIIKP
T65 PEAASLGTIIKPLVE
Y73 IIKPLVEYDDISSDS
S77 LVEYDDISSDSDTFS
S78 VEYDDISSDSDTFSD
S80 YDDISSDSDTFSDDT
S84 SSDSDTFSDDTAFKS
S157 SKRSVEGSDDYGKAQ
Y160 SVEGSDDYGKAQLSK
S175 SGSKESRSSKMHKEK
S176 GSKESRSSKMHKEKT
K202 DRSKSHRKRETPKSY
K210 RETPKSYKTVASPKR
S214 KSYKTVASPKRRSRS
S227 RSPHRKWSDSSKQDD
S229 PHRKWSDSSKQDDSP
S235 DSSKQDDSPSGASYG
S237 SKQDDSPSGASYGQD
Y245 GASYGQDYDLSPPRS
S248 YGQDYDLSPPRSHTS
P250 QDYDLSPPRSHTSSN
T254 LSPPRSHTSSNYDSY
S255 SPPRSHTSSNYDSYK
S256 PPRSHTSSNYDSYKK
S260 HTSSNYDSYKKSPGS
S264 NYDSYKKSPGSTSRR
S269 KKSPGSTSRRQSISP
S273 GSTSRRQSISPPYKE
S275 TSRRQSISPPYKEPS
Y278 RQSISPPYKEPSAYQ
S282 SPPYKEPSAYQSSTR
Y284 PYKEPSAYQSSTRSP
S286 KEPSAYQSSTRSPSP
S287 EPSAYQSSTRSPSPY
S290 AYQSSTRSPSPYSRR
S292 QSSTRSPSPYSRRQR
S300 PYSRRQRSVSPYSRR
S302 SRRQRSVSPYSRRRS
Y304 RQRSVSPYSRRRSSS
S305 QRSVSPYSRRRSSSY
S309 SPYSRRRSSSYERSG
S310 PYSRRRSSSYERSGS
S311 YSRRRSSSYERSGSY
S317 SSYERSGSYSGRSPS
Y318 SYERSGSYSGRSPSP
S319 YERSGSYSGRSPSPY
S322 SGSYSGRSPSPYGRR
S324 SYSGRSPSPYGRRRS
Y326 SGRSPSPYGRRRSSS
R328 RSPSPYGRRRSSSPF
R329 SPSPYGRRRSSSPFL
R330 PSPYGRRRSSSPFLS
S331 SPYGRRRSSSPFLSK
S332 PYGRRRSSSPFLSKR
S333 YGRRRSSSPFLSKRS
S337 RSSSPFLSKRSLSRS
S340 SPFLSKRSLSRSPLP
S342 FLSKRSLSRSPLPSR
S344 SKRSLSRSPLPSRKS
S348 LSRSPLPSRKSMKSR
S354 PSRKSMKSRSRSPAY
S356 RKSMKSRSRSPAYSR
S358 SMKSRSRSPAYSRHS
Y361 SRSRSPAYSRHSSSH
S362 RSRSPAYSRHSSSHS
S381 SGSRSRHSSISPVRL
S382 GSRSRHSSISPVRLP
S384 RSRHSSISPVRLPLN
S392 PVRLPLNSSLGAELS
S393 VRLPLNSSLGAELSR
S399 SSLGAELSRKKKERA
S419 AKMDGKESKSSPIIL
S422 DGKESKSSPIILPKK
K431 IILPKKEKLEVKESG
R446 LESKKLPRSIKSEKS
S453 RSIKSEKSTPDTELV
K501 AQGTKDVKPVAPKEV
K506 DVKPVAPKEVIVTSK
T511 APKEVIVTSKETETS
T517 VTSKETETSEKETLP
S518 TSKETETSEKETLPP
T588 PSSPHPRTSTLSSQT
S589 SSPHPRTSTLSSQTN
S593 PRTSTLSSQTNSQPP
T595 TSTLSSQTNSQPPVQ
S640 PGDDDMDSPKETLPS
T644 DMDSPKETLPSKPAK
S647 SPKETLPSKPAKKEK
S677 ELPGGDPSPPDSPEP
S681 GDPSPPDSPEPKAIT
T688 SPEPKAITPPQQPYK
S882 GLARLYNSEESRPYT
S885 RLYNSEESRPYTNKV
Y888 NSEESRPYTNKVITL
T889 SEESRPYTNKVITLW
S987 EEFSFIPSAALDLLD
T998 DLLDHMLTLDPSKRC
S1002 HMLTLDPSKRCTAEQ
T1006 LDPSKRCTAEQTLQS
S1049 KRRRQRQSGIVIEDP
S1059 VIEDPPPSKASRKET
S1062 DPPPSKASRKETTSG
T1066 SKASRKETTSGTTAE
T1067 KASRKETTSGTTAEP
N1078 TAEPVKNNSPAPPQP
S1079 AEPVKNNSPAPPQPA
T1240-p GPQGPRRtPtMPQEE
T1242-p QGPRRtPtMPQEEAA
T1350 RSSGPALTESLVQTP
S1352 SGPALTESLVQTPVK
T1356 LTESLVQTPVKNRTF
T1362 QTPVKNRTFSGSVSH
N1374 VSHLGESNSYQGTGS
R1391 FPGDQDLRFTRVPLA
K1455 GPAQSYGKPYRGAAR
  CDK12 iso4  
S14 HGGKKDGSGGASGTS
S18 KDGSGGASGTSQPSS
S24 ASGTSQPSSGGGSSN
S25 SGTSQPSSGGGSSNS
S32 SGGGSSNSRERHRLV
T57-p SKDVGLVtPEAAsLG
S62-p LVtPEAAsLGtIIKP
T65-p PEAAsLGtIIKPLVD
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- gap
S76 PLVDPLPSRKSMKSR
S82 PSRKSMKSRSRSPAY
S84 RKSMKSRSRSPAYSR
S86 SMKSRSRSPAYSRHS
Y89 SRSRSPAYSRHSSSH
S90 RSRSPAYSRHSSSHS
S109 SGSRSRHSSISPVRL
S110 GSRSRHSSISPVRLP
S112 RSRHSSISPVRLPLN
S120 PVRLPLNSSLGAELS
S121 VRLPLNSSLGAELSR
S127 SSLGAELSRKKKERA
S147 AKMDGKESKSSPIIL
S150 DGKESKSSPIILPKK
K159 IILPKKEKLEVKESG
R174 LESKKLPRSIKSEKS
S181 RSIKSEKSTPDTELV
K229 AQGTKDVKPVAPKEV
K234 DVKPVAPKEVIVTSK
T239 APKEVIVTSKETETS
T245 VTSKETETSEKETLP
S246 TSKETETSEKETLPP
T316 PSSPHPRTSTLSSQT
S317 SSPHPRTSTLSSQTN
S321 PRTSTLSSQTNSQPP
T323 TSTLSSQTNSQPPVQ
S368 PGDDDMDSPKETLPS
T372 DMDSPKETLPSKPAK
S375 SPKETLPSKPAKKEK
S405 ELPGGDPSPPDSPEP
S409 GDPSPPDSPEPKAIT
T416 SPEPKAITPPQQPYK
S610 GLARLYNSEESRPYT
S613 RLYNSEESRPYTNKV
Y616 NSEESRPYTNKVITL
T617 SEESRPYTNKVITLW
S715 EEFSFIPSAALDLLD
T726 DLLDHMLTLDPSKRC
S730 HMLTLDPSKRCTAEQ
T734 LDPSKRCTAEQTLQS
S777 KRRRQRQSGIVIEDP
S787 VIEDPPPSKASRKET
S790 DPPPSKASRKETTSG
T794 SKASRKETTSGTTAE
T795 KASRKETTSGTTAEP
N806 TAEPVKNNSPAPPQP
S807 AEPVKNNSPAPPQPA
T968 GPQGPRRTPTMPQEE
T970 QGPRRTPTMPQEEAA
T1078 RSSGPALTESLVQTP
S1080 SGPALTESLVQTPVK
T1084 LTESLVQTPVKNRTF
T1090 QTPVKNRTFSGSVSH
N1102 VSHLGESNSYQGTGS
R1119 FPGDQDLRFTRVPLA
K1183 GPAQSYGKPYRGAAR
  rat

 
S14 HGGKKDGSGGASGTS
S18 KDGSGGASGTSQPSS
S24 ASGTSQPSSGGGSSN
S25 SGTSQPSSGGGSSNS
S32 SGGGSSNSRERHRLV
T57 SKDMGLVTPEAASLG
S62 LVTPEAASLGTIIKP
T65 PEAASLGTIIKPLVE
Y73 IIKPLVEYDDISSDS
S77 LVEYDDISSDSDTFS
S78 VEYDDISSDSDTFSD
S80 YDDISSDSDTFSDDM
S84 SSDSDTFSDDMAFKS
N157 SKRSVEGNDDYGKAQ
Y160 SVEGNDDYGKAQLSK
S175 SSSKESRSSKMHKEK
S176 SSKESRSSKMHKEKT
K202 DRSKSHRKRETPKSY
K210 RETPKSYKTVDSPKR
S214 KSYKTVDSPKRRSRS
S227 RSPHRKWSDSSKQDD
S229 PHRKWSDSSKQDDSP
S235 DSSKQDDSPSGASYG
S237 SKQDDSPSGASYGQD
Y245 GASYGQDYDLSPPRS
S248 YGQDYDLSPPRSHTS
P250 QDYDLSPPRSHTSSN
T254 LSPPRSHTSSNYDSY
S255 SPPRSHTSSNYDSYK
S256 PPRSHTSSNYDSYKK
S260 HTSSNYDSYKKSPGS
S264 NYDSYKKSPGSTSRR
S269 KKSPGSTSRRQSISP
S273 GSTSRRQSISPPYKE
S275 TSRRQSISPPYKEPS
Y278 RQSISPPYKEPSAYQ
S282 SPPYKEPSAYQSSTR
Y284 PYKEPSAYQSSTRSP
S286 KEPSAYQSSTRSPSP
S287 EPSAYQSSTRSPSPY
S290 AYQSSTRSPSPYSRR
S292 QSSTRSPSPYSRRQR
S300 PYSRRQRSVSPYSRR
S302 SRRQRSVSPYSRRRS
Y304 RQRSVSPYSRRRSSS
S305 QRSVSPYSRRRSSSY
S309 SPYSRRRSSSYERSG
S310 PYSRRRSSSYERSGS
S311 YSRRRSSSYERSGSY
S317 SSYERSGSYSGRSPS
Y318 SYERSGSYSGRSPSP
S319 YERSGSYSGRSPSPY
S322 SGSYSGRSPSPYGRR
S324 SYSGRSPSPYGRRRS
Y326 SGRSPSPYGRRRSSS
R328 RSPSPYGRRRSSSPF
R329 SPSPYGRRRSSSPFL
R330 PSPYGRRRSSSPFLS
S331 SPYGRRRSSSPFLSK
S332 PYGRRRSSSPFLSKR
S333 YGRRRSSSPFLSKRS
S337 RSSSPFLSKRSLSRS
S340 SPFLSKRSLSRSPIS
S342 FLSKRSLSRSPISSR
S344 SKRSLSRSPISSRKS
S348 LSRSPISSRKSMKSR
S354 SSRKSMKSRSRSPAY
S356 RKSMKSRSRSPAYSR
S358 SMKSRSRSPAYSRHS
Y361 SRSRSPAYSRHSSSH
S362 RSRSPAYSRHSSSHS
S381 SGSRSRHSsIsPVRL
S382-p GSRSRHSsIsPVRLP
S384-p RSRHSsIsPVRLPLN
S392 PVRLPLNSSLGAELS
S393 VRLPLNSSLGAELSR
S399 SSLGAELSRKKKERA
S419 AKLDGKESKGSPIIL
S422 DGKESKGSPIILPKK
K431 IILPKKEKFEVKESG
R446 LESKKLPRGIKSEKS
S453 RGIKSEKSTPDTELV
K501 AQGTKDTKPVALKEV
K506 DTKPVALKEVIVTSK
T511 ALKEVIVTSKETETS
T517 VTSKETETSEKEALP
S518 TSKETETSEKEALPP
T588 PSSPHPRTSTLSSQT
S589 SSPHPRTSTLSSQTN
S593 PRTSTLSSQTNSQPL
T595 TSTLSSQTNSQPLVQ
S640 PGDDDMDSPKEMLPS
M644 DMDSPKEMLPSKPAK
S647 SPKEMLPSKPAKKEK
S677-p ELPGGDPsPPDsPEP
S681-p GDPsPPDsPEPKAIt
T688-p sPEPKAItPPQQPYK
S882 GLARLYNSEEsRPYt
S885-p RLYNSEEsRPYtNKV
Y888 NSEEsRPYtNKVITL
T889-p SEEsRPYtNKVITLW
S987 EEFSFIPSAALDLLD
T998 DLLDHMLTLDPSKRC
S1002 HMLTLDPSKRCTAEQ
T1006 LDPSKRCTAEQTLQS
S1049 KRRRQRQSGIVIEEQ
S1059 VIEEQPPSKASRKET
S1062 EQPPSKASRKETTSG
T1066 SKASRKETTSGTAAE
T1067 KASRKETTSGTAAEP
S1078 AAEPVKNSsPAPPQP
S1079-p AEPVKNSsPAPPQPA
T1240 GPQGPRRTPTMPQEE
T1242 QGPRRTPTMPQEEAA
T1359 RSSGPALTESLVQTL
S1361 SGPALTESLVQTLVK
T1365 LTESLVQTLVKNRTF
T1371 QTLVKNRTFSGSVSH
N1383 VSHLGESNSYQGTGS
R1400 FPGDQDLRFTRVPLA
K1464 GPAQSFGKPYRGAAR
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