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Protein Page:
PKD2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PKD2 a calcium-independent, phospholipid-dependent CAMK kinase of the PKD family. Activated by diacylglycerol and phorbol esters. may play a role in carcinoid tumor progression. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; EC 2.7.11.13; Motility/polarity/chemotaxis; CAMK group; PKD family
Cellular Component: Golgi apparatus; cytoplasm; plasma membrane; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; protein kinase C activity; metal ion binding; ATP binding; protein kinase activity
Biological Process: cell death; positive regulation of cell adhesion; protein amino acid autophosphorylation; positive regulation of blood vessel endothelial cell migration; activation of CREB transcription factor; positive regulation of fibroblast growth factor receptor signaling pathway; T cell receptor signaling pathway; protein amino acid phosphorylation; positive regulation of peptidyl-serine phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; peptidyl-serine phosphorylation; positive regulation of angiogenesis; positive regulation of T cell receptor signaling pathway; positive regulation of interleukin-2 production; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; angiogenesis; vascular endothelial growth factor receptor signaling pathway; cell adhesion
Reference #:  Q9BZL6 (UniProtKB)
Alt. Names/Synonyms: HSPC187; KPCD2; nPKC-D2; PKD2; PRKD2; protein kinase D2; Serine/threonine-protein kinase D2
Gene Symbols: PRKD2
Molecular weight: 96,750 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PKD2

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S706‑p, S710‑p, S876‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K80-ub ACSIVDQkFPECGFY
0 1 K92-ub GFYGLYDkILLFKHD
0 4 K178-ub GCGLNYHkRCAFSIP
0 1 S189-p FSIPNNCsGARKRRL
0 332 S197-p GARKRRLsstsLAsG
1 186 S198-p ARKRRLsstsLAsGH
0 42 T199-p RKRRLsstsLAsGHs
0 60 S200-p KRRLsstsLAsGHsV
0 39 S203-p LsstsLAsGHsVRLG
0 32 S206-p tsLAsGHsVRLGtsE
0 20 T211-p GHsVRLGtsEsLPCT
0 5 S212-p HsVRLGtsEsLPCTA
0 84 S214-p VRLGtsEsLPCTAEE
0 1 S225-p TAEELSRsTtELLPR
0 3 T227-p EELSRsTtELLPRRP
0 8 S236-p LLPRRPPssssSssA
0 2 S237-p LPRRPPssssSssAs
0 3 S238-p PRRPPssssSssAss
0 1 S239-p RRPPssssSssAssy
0 3 S241-p PPssssSssAssyTG
0 5 S242-p PssssSssAssyTGR
1 1 S244-p sssSssAssyTGRPI
0 2 S245-p ssSssAssyTGRPIE
0 4 Y246-p sSssAssyTGRPIEL
0 1 Y272-p HTFLIHSyTRPTVCQ
0 2 K286-ub QACKKLLkGLFRQGL
0 1 S355-p GVIPGSHsENALHAS
0 1 S374-p GEGGKAQssLGyIPL
0 12 S375-p EGGKAQssLGyIPLM
0 16 Y378-p KAQssLGyIPLMRVV
0 8 S387-p PLMRVVQsVRHttRK
0 8 T391-p VVQsVRHttRKssTt
0 5 T392-p VQsVRHttRKssTtL
0 11 S395-p VRHttRKssTtLREG
0 49 S396-p RHttRKssTtLREGW
0 3 T398-p ttRKssTtLREGWVV
0 7 T412-p VHYSNKDtLRKRHYW
0 2 K424-ub HYWRLDCkCITLFQN
0 2 Y438-p NNTTNRYyKEIPLSE
0 11 S518-p VILQDAPsAPGHAPH
0 1 S529-p HAPHRQAsLSISVSN
0 1 K572-ac VYGGKHRkTGRDVAV
0 1 K580-ac TGRDVAVkVIDkLRF
0 1 K584-ac VAVkVIDkLRFPTKQ
0 1 T619-p NLECMFEtPEKVFVV
0 2 K705-ub FARIIGEksFRRsVV
5 27 S706-p ARIIGEksFRRsVVG
5 60 S710-p GEksFRRsVVGtPAy
0 15 T714-p FRRsVVGtPAyLAPE
0 39 Y717-p sVVGtPAyLAPEVLL
4 5 S876-p QGLAERIsVL_____
  mouse

 
K80 ACSIVDQKFPECGFY
K92 GFYGLYDKILLFKHD
K178 GCGLNYHKRCAFSIP
S189 FSIPNNCSGARKRRL
S197-p GARKRRLsstsLAsG
S198-p ARKRRLsstsLAsGH
T199-p RKRRLsstsLAsGHs
S200-p KRRLsstsLAsGHsV
S203-p LsstsLAsGHsVRLG
S206-p tsLAsGHsVRLGssE
S211-p GHsVRLGssEsLPCT
S212-p HsVRLGssEsLPCTA
S214-p VRLGssEsLPCTAEE
S225 TAEELSRSTTDLLPR
T227 EELSRSTTDLLPRRP
S236 LLPRRPPSSSSSSSS
S237 LPRRPPSSSSSSSSS
S238 PRRPPSSSSSSSSSS
S239 RRPPSSSSSSSSSSF
S241 PPSSSSSSSSSSFYT
S242 PSSSSSSSSSSFYTG
S244 SSSSSSSSSFYTGRP
S245 SSSSSSSSFYTGRPI
Y247 SSSSSSFYTGRPIEL
Y273 HTFLIHSYTRPTVCQ
K287-ub QACKKLLkGLFRQGL
S356 GVIPGSHSESALHAS
S375 GEGHKAQSsLGYIPL
S376-p EGHKAQSsLGYIPLM
Y379 KAQSsLGYIPLMRVV
S388-p PLMRVVQsVRHTTRK
T392 VVQsVRHTTRKSsTt
T393 VQsVRHTTRKSsTtL
S396 VRHTTRKSsTtLREG
S397-p RHTTRKSsTtLREGW
T399-p TTRKSsTtLREGWVV
T413 VHYSNKDTLRKRHYW
K425 HYWRLDCKCITLFQN
Y439 NNTTNRYYKEIPLSE
S519 VILQDAPSAPGHTPH
S530 HTPHRQASLSISVSN
K573 VYGGKHRKTGRDVAV
K581 TGRDVAVKVIDKLRF
K585 VAVKVIDKLRFPTKQ
T620 NLECMFETPEKVFVV
K706-ub FARIIGEksFRRsVV
S707-p ARIIGEksFRRsVVG
S711-p GEksFRRsVVGtPAY
T715-p FRRsVVGtPAYLAPE
Y718 sVVGtPAYLAPEVLL
S873-p QGLAERIsIL_____
  rat

 
K80 ACSIVDQKFPECGFY
K92 GFYGLYDKILLFKHD
K178 GCGLNYHKRCAFSIP
S189 FSIPNNCSGARKRRL
S197-p GARKRRLsSTSLASG
S198 ARKRRLsSTSLASGH
T199 RKRRLsSTSLASGHS
S200 KRRLsSTSLASGHSV
S203 LsSTSLASGHSVRLG
S206 TSLASGHSVRLGsSE
S211-p GHSVRLGsSEsLPCT
S212 HSVRLGsSEsLPCTA
S214-p VRLGsSEsLPCTAEE
S225 TAEELSRSTTDLLPR
T227 EELSRSTTDLLPRRP
S236 LLPRRPPSSSSSSSS
S237 LPRRPPSSSSSSSSS
S238 PRRPPSSSSSSSSSS
S239 RRPPSSSSSSSSSSF
S241 PPSSSSSSSSSSFYT
S242 PSSSSSSSSSSFYTG
S244 SSSSSSSSSFYTGRP
S245 SSSSSSSSFYTGRPI
Y247 SSSSSSFYTGRPIEL
Y273 HTFLIHSYTRPTVCQ
K287 QACKKLLKGLFRQGL
A356 GVIPGSHAENALHAS
S375 GEGGKAQSSLGYIPL
S376 EGGKAQSSLGYIPLM
Y379 KAQSSLGYIPLMRVV
S388 PLMRVVQSVRHTTRK
T392 VVQSVRHTTRKSSTT
T393 VQSVRHTTRKSSTTL
S396 VRHTTRKSSTTLREG
S397 RHTTRKSSTTLREGW
T399 TTRKSSTTLREGWVV
T413 VHYSNKDTLRKRHYW
K425 HYWRLDCKCITLFQN
Y439 NNTTNRYYKEIPLSE
S519 VILQDAPSAPGHTPH
S530 HTPHRQASLSISVSN
K573 VYGGKHRKTGRDVAV
K581 TGRDVAVKVIDKLRF
K585 VAVKVIDKLRFPTKQ
T620 NLECMFETPEKVFVV
K706 FARIIGEKSFRRSVV
S707 ARIIGEKSFRRSVVG
S711 GEKSFRRSVVGTPAY
T715 FRRSVVGTPAYLAPE
Y718 SVVGTPAYLAPEVLL
S873 QGLAERISIL_____
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