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Protein Page:
NKD2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
NKD2 Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. Interacts with DVL1, DVL2, DVL3 and PPP2R3A. Interacts with RNF25 and TGFA (via cytoplasmic domain). Expressed in kidney, lung, pancreas and spleen. Belongs to the NKD family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system; Cell development/differentiation
Cellular Component: basolateral plasma membrane; cytoplasmic membrane-bound vesicle; cytoplasmic vesicle; lateral plasma membrane
Molecular Function: protein binding; growth factor binding; ubiquitin protein ligase binding; calcium ion binding
Biological Process: exocytosis; Wnt receptor signaling pathway; Golgi vesicle fusion to target membrane; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Reference #:  Q969F2 (UniProtKB)
Alt. Names/Synonyms: Dvl-binding protein NKD2; hNkd2; naked cuticle homolog 2 (Drosophila); naked cuticle-2; Naked-2; Naked2; NKD2; Protein naked cuticle homolog 2
Gene Symbols: NKD2
Molecular weight: 50,055 Da
Basal Isoelectric point: 7.83  Predict pI for various phosphorylation states
CST Pathways:  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NKD2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S23-p RESPEGDsFVASAYA
0 4 S31-p FVASAYAsGRKGAEE
0 1 S146 VTREDMSSLMHTIYE
0 1 Y152 SSLMHTIYEVVDASV
0 1 S162 VDASVNHSSGSSKTL
0 1 S166 VNHSSGSSKTLRVKL
0 1 T168 HSSGSSKTLRVKLTV
0 5 S216-p RVADRRLsAHVRRPs
0 2 S223-p sAHVRRPstDPQPCs
0 2 T224-p AHVRRPstDPQPCsE
0 3 S230-p stDPQPCsERGPYCV
0 11 Y247-p NTERRNHyLDLAGIE
0 10 Y256-p DLAGIENyTSRFGPG
0 1 S286-p HLQARSRsQEPDTHA
0 2 K324 LDTQPRPKGPEKQFL
0 2 K328 PRPKGPEKQFLKSPK
  mouse

 
S23 RESPEGDSFVVPAYG
S31 FVVPAYGSGRRGAEE
S154 VTREDMSSLMHTIYE
Y160 SSLMHTIYEVVDASV
S170 VDASVNHSSGSSKTL
S174 VNHSSGSSKTLRVKL
T176 HSSGSSKTLRVKLTV
S223 RVADRRLSAYSRKPN
N230 SAYSRKPNADPQPCS
A231 AYSRKPNADPQPCSV
S237 NADPQPCSVRVPYCV
Y254 NTERRNHYLDLAGIE
Y263 DLAGIENYTSKFGPG
S293 HIPSRSRSQESDAHA
K331-a LAAQPRIkGQEkQFL
K335-a PRIkGQEkQFLRSPK
  rat

 
S20 RESPEGDSFVVSAYA
S28 FVVSAYASGRKGAEE
S149-p VTREDMSsLMHTIyE
Y155-p SsLMHTIyEVVDASV
S165-p VDASVNHsSGSsKtL
S169-p VNHsSGSsKtLRVKL
T171-p HsSGSsKtLRVKLTV
S218 RVADRRLSAYSRKPN
N225 SAYSRKPNTDPQPCP
T226 AYSRKPNTDPQPCPV
P232 NTDPQPCPVRVPYCV
Y249 NTERRNHYLDLAGIE
Y258 DLAGIENYTSKFGPG
S288 HIPSRSRSQESDAHA
K326 LAAQPRLKGQEKQFL
K330 PRLKGQEKQFLRSPK
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