Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
NKD1 (human)

Overview
NKD1 Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Interacts with DVL1, DVL2, DVL3 and PPP2R3A. Expression is induced by activation of the Wnt signaling pathway. Expressed in colon, heart, kidney, leukocyte, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine and spleen. Belongs to the NKD family. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation
Cellular Component: protein phosphatase type 2A complex; cytoplasm; plasma membrane
Molecular Function: protein binding; calcium ion binding; PDZ domain binding
Biological Process: Wnt receptor signaling pathway; positive regulation of protein catabolic process; eye photoreceptor cell differentiation; somatic muscle development
Reference #:  Q969G9 (UniProtKB)
Alt. Names/Synonyms: Dvl-binding protein; hNkd; hNkd1; naked cuticle homolog 1 (Drosophila); naked cuticle-1; Naked-1; Naked1; NKD; NKD1; Protein naked cuticle homolog 1
Gene Symbols: NKD1
Molecular weight: 52,285 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
CST Pathways:  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NKD1

Protein Structure Not Found.


STRING  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S48-p QRCPGGVsGPRQLRL
0 1 T94-p VALPPEKtDGLGSGD
0 1 S109 EKKMERVSEPCPGsK
0 1 S115-p VSEPCPGsKKQLKFE
0 4 Y245-p RLEQSGCyHHCVDEN
0 6 Y259-p NIERRNHyLDLAGIE
0 5 Y268-p DLAGIENyTSQFGPG
0 4 Y441-p ELPALVVyESQAGQP
  mouse

 
S48 QRCPGSVSGPRQLRL
I94 VALPPEKIDSLGSGD
S109-p EKRMERLsEPGQASK
S115 LsEPGQASKKQLKFE
Y245 HLEQPDCYHHCVDEN
Y259 NIERRNHYLDLAGIE
Y268 DLAGIENYTSQFGPG
Y442 ELPAVVVYESQAGQA
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.