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NKD1 (human)

Overview NKD1 Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Interacts with DVL1, DVL2, DVL3 and PPP2R3A. Expression is induced by activation of the Wnt signaling pathway. Expressed in colon, heart, kidney, leukocyte, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine and spleen. Belongs to the NKD family. Note: This description may include information from UniProtKB. Protein type: Cell development/differentiation Cellular Component: protein phosphatase type 2A complex; cytoplasm; plasma membrane Molecular Function: protein binding; calcium ion binding Biological Process: Wnt receptor signaling pathway; positive regulation of protein catabolic process; eye photoreceptor cell differentiation; somatic muscle development Reference #:  Q969G9 (UniProtKB) Alt. Names/Synonyms: Dvl-binding protein; hNkd; hNkd1; naked cuticle homolog 1 (Drosophila); naked cuticle-1; Naked-1; Naked1; NKD; NKD1; Protein naked cuticle homolog 1 Gene Symbols: NKD1 Molecular weight: 52,285 Da Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states CST Pathways:  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NKD1

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S48-p	QRCPGGVsGPRQLRL
0	1		T94-p	VALPPEKtDGLGSGD
0	1		S109	EKKMERVSEPCPGsK
0	1		S115-p	VSEPCPGsKKQLKFE
0	4		Y245-p	RLEQSGCyHHCVDEN
0	6		Y259-p	NIERRNHyLDLAGIE
0	5		Y268-p	DLAGIENyTSQFGPG
0	4		Y441-p	ELPALVVyESQAGQP

	mouse
S48	QRCPGSVSGPRQLRL
I94	VALPPEKIDSLGSGD
S109-p	EKRMERLsEPGQASK
S115	LsEPGQASKKQLKFE
Y245	HLEQPDCYHHCVDEN
Y259	NIERRNHYLDLAGIE
Y268	DLAGIENYTSQFGPG
Y442	ELPAVVVYESQAGQA

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