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Overview |
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JUB
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell- cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1- induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Interacts with GRB2, PIP5K1B and SLC1A2. Interacts with AURKA; the interaction occurs during mitosis and both proteins are phosphorylated as they form a complex. Interacts with CTNNA1 and with F-actin. Interacts with LATS2; the interaction occurs during mitosis and the complex regulates organization of the spindle apparatus through recruitment of TUBG to the centrosome. Forms a complex with SQSTM1, PRKCZ and TRAF6. Component of the GFI1-AJUBA-HDAC1 repressor complex. Interacts directly (via the LIM domains) with GFI1; the interaction results in the HDAC-dependent corepression of a subset of GFI1 target genes, and is independent of the GFI1 SNAG domain. Interacts with HDAC1, HDAC2 and HDAC3. Interacts with SNAI2/SLUG (via SNAG domain) and SCRT1 (via SNAG domain). Interacts with EIF4E, EIF2C1, EIF2C2, DCP2, DDX6, LATS1, LATS2, SAV1, EGLN2/PHD1 and EGLN3/PHD3. Interacts (via LIM domains) with isoform 1 and isoform 3 of VHL. Interacts (via LIM domains) with SNAI1 (via SNAG domain). Belongs to the zyxin/ajuba family. Note: This description may include information from UniProtKB.
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| Protein type: Transcription, coactivator/corepressor; Cell adhesion; Motility/polarity/chemotaxis |
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Cellular Component: transcription factor complex; focal adhesion; lamellipodium; plasma membrane; microtubule organizing center; intercellular junction; cytosol; nucleus
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Molecular Function: actin filament binding; protein binding; zinc ion binding; chromatin binding; transcription corepressor activity; alpha-catenin binding
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Biological Process: focal adhesion formation; lamellipodium biogenesis; negative regulation of kinase activity; regulation of GTPase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; glycerophospholipid biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; cell cycle; miRNA-mediated gene silencing; positive regulation of cellular biosynthetic process; regulation of cell migration; positive regulation of MAP kinase activity; positive regulation of protein complex assembly; calcium-dependent cell-cell adhesion; response to hypoxia; wound healing, spreading of epidermal cells
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Reference #:
Q96IF1 (UniProtKB)
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| Alt. Names/Synonyms: Ajuba; JUB; jub, ajuba homolog (Xenopus laevis); MGC15563; Protein ajuba |
| Gene Symbols: AJUBA |
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Molecular weight: 56,934 Da
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Basal Isoelectric point: 6.86
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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Select Structure to View Below |
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JUB |
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