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QIK (human)

Overview QIK a serine/threonine kinase of the CAMKL family and related to AMPK. Specifically expressed in adipose tissues. Like AMPK, QIK is phosphorylated and activated by LKB1. Part of a molecular complex including TORC2 and calcineurin that regulates the effects of circulating glucose and gut hormones during feeding on TORC2-mediated gene expression. In mice, insulin promotes the phosphorylation and ubiquitin-dependent degradation of TORC2, inhibiting gluconeogenic gene expression during re-feeding. In response to insulin, Akt2 phosphorylates and activates QIK which in turn stimulates the phosphorylation and cytoplasmic translocation of TORC2 where it associates with COP1, which promotes its ubiquitination and proteasomal degradation. Phosphorylates Ser794 of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3. Note: This description may include information from UniProtKB. Protein type: Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; CAMK group; CAMKL family; QIK subfamily Cellular Component: Golgi apparatus; cytoplasm; nucleus Molecular Function: protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding Biological Process: regulation of insulin receptor signaling pathway; protein amino acid autophosphorylation; protein kinase cascade; insulin receptor signaling pathway; protein amino acid phosphorylation Reference #:  Q9H0K1 (UniProtKB) Alt. Names/Synonyms: DKFZp434K1115; KIAA0781; LOH11CR1I; QIK; Qin-induced kinase; salt-inducible kinase 2; Salt-inducible protein kinase 2; salt-inducible serine/threonine kinase 2; Serine/threonine-protein kinase SIK2; Serine/threonine-protein kinase SNF1-like kinase 2; SIK-2; SIK2; SNF1-like kinase 2; SNF1LK2 Gene Symbols: SIK2 Molecular weight: 103,915 Da Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below QIK

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T25-p	GFYDIEGtLGKGNFA
1	0		K53-a	VAIKIIDkSQLDAVN
0	1		Y65-p	AVNLEKIyREVQIMK
1	0		S90-p	YQVMETKsMLYLVTE
0	1		K144-u	KIVHRDLkAENLLLD
3	0		T175-p	KSGELLAtWCGSPPY
1	0		S179	LLAtWCGSPPYAAPE
0	1		Y283-p	PVQRPVLyPQEQENE
2	4		S343-p	RLKSHRSsFPVEQRL
2	111		S358-p	DGRQRRPstIAEQTV
0	17		T359-p	GRQRRPstIAEQTVA
0	3		S379-p	GLPVTMHsPNMRLLR
2	79		T484-p	RSGQRRHtLsEVTNQ
0	5		S486-p	GQRRHtLsEVTNQLV
1	1		S512-p	NDSPSLDsVDSEYDM
0	1		S521	DSEYDMGSVQRDLNF
0	1		N532	DLNFLEDNPsLkDIM
1	6		S534-p	NFLEDNPsLkDIMLA
0	1		K536-u	LEDNPsLkDIMLANQ
1	1		S576-p	KREVHNRsPVSFREG
2	25		S587-p	FREGRRAsDtsLTQG
0	1		T589-p	EGRRAsDtsLTQGIV
0	1		S590-p	GRRAsDtsLTQGIVA
0	1		K692-u	QKPSLLSkAQNTCQL
0	1		Y700-p	AQNTCQLyCKEPPRS

	mouse
T25	GFYDIEGTLGKGNFA
K53	VAIKIIDKSQLDAVN
Y65	AVNLEKIYREVQIMK
S90	YQVMETKSMLYLVTE
K144	KVVHRDLKAENLLLD
T175	KTGELLATWCGSPPY
S179	LLATWCGSPPYAAPE
Y283	PVQRPILYPQEQENE
S343-p	RLKSHRSsFPVEQRL
S358-p	DGRQRRPstIAEQTV
T359-p	GRQRRPstIAEQTVA
P379	GLPVTLHPPNVRLMR
T484-p	RSGQRRHtLsEVTNQ
S486-p	GQRRHtLsEVTNQLV
S512-p	SDNPSLEsVDSEYDM
S521-p	DSEYDMGsAQRDLNF
S532-p	DLNFLEDsPsLKDIM
S534-p	NFLEDsPsLKDIMLA
K536	LEDsPsLKDIMLANQ
S576	KREAHNRSPVSFREG
S587-p	FREGRRAsDTsLTQG
T589	EGRRAsDTsLTQGIV
S590-p	GRRAsDTsLTQGIVA
K692	QKPNLLPKAQSPCPV
Y700	AQSPCPVYCKEPPRS

	rat
T25	GFYDIEGTLGKGNFA
K53	VAIKIIDKSQLDAVN
Y65	AVNLEKIYREVQIMK
S90	YQVMETKSMLYLVTE
K144	KVVHRDLKAENLLLD
T175-p	KTGELLAtWCGsPPY
S179-p	LLAtWCGsPPYAAPE
Y283	PVQRPILYPQEQENE
S343	RLKSHRSSFPVEQRL
S358	DGRQRRPSTIAEQTV
T359	GRQRRPSTIAEQTVA
P379	GLPVTLHPPNLRLMR
T484-p	RSGQRRHtLSEVTNQ
S486	GQRRHtLSEVTNQLV
S512	SDSPSLDSVDSEYDM
S521	DSEYDMGSAQRDLNF
S532	DLNFPEDSPSLKDIM
S534	NFPEDSPSLKDIMLA
K536	PEDSPSLKDIMLANQ
S575	RREAHNRSPVSFREG
S586-p	FREGRRAsDTPLTQG
T588	EGRRAsDTPLTQGIV
P589	GRRAsDTPLTQGIVA
K691	QKPSLLPKAQNACPM
Y699	AQNACPMYCKEPPRS

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