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Protein Page:
QIK (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
QIK a serine/threonine kinase of the CAMKL family and related to AMPK. Specifically expressed in adipose tissues. Like AMPK, QIK is phosphorylated and activated by LKB1. Part of a molecular complex including TORC2 and calcineurin that regulates the effects of circulating glucose and gut hormones during feeding on TORC2-mediated gene expression. In mice, insulin promotes the phosphorylation and ubiquitin-dependent degradation of TORC2, inhibiting gluconeogenic gene expression during re-feeding. In response to insulin, Akt2 phosphorylates and activates QIK which in turn stimulates the phosphorylation and cytoplasmic translocation of TORC2 where it associates with COP1, which promotes its ubiquitination and proteasomal degradation. Phosphorylates Ser794 of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, CAMK; CAMK group; CAMKL family; QIK subfamily
Cellular Component: cytoplasm; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding
Biological Process: regulation of insulin receptor signaling pathway; protein amino acid autophosphorylation; insulin receptor signaling pathway; protein amino acid phosphorylation
Reference #:  Q9H0K1 (UniProtKB)
Alt. Names/Synonyms: DKFZp434K1115; KIAA0781; LOH11CR1I; QIK; Qin-induced kinase; salt-inducible kinase 2; Salt-inducible protein kinase 2; salt-inducible serine/threonine kinase 2; Serine/threonine-protein kinase SIK2; Serine/threonine-protein kinase SNF1-like kinase 2; SIK-2; SIK2; SNF1-like kinase 2; SNF1LK2
Gene Symbols: SIK2
Molecular weight: 103,915 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

QIK

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T25-p GFYDIEGtLGKGNFA
1 0 K53-ac VAIKIIDkSQLDAVN
0 1 Y65-p AVNLEKIyREVQIMK
1 0 S90-p YQVMETKsMLYLVTE
0 1 K144-ub KIVHRDLkAENLLLD
4 0 T175-p KSGELLAtWCGSPPY
1 0 S179 LLAtWCGSPPYAAPE
0 1 Y283-p PVQRPVLyPQEQENE
2 4 S343-p RLKSHRSsFPVEQRL
2 135 S358-p DGRQRRPstIAEQTV
0 17 T359-p GRQRRPstIAEQTVA
0 5 S379-p GLPVTMHsPNMRLLR
2 87 T484-p RSGQRRHtLsEVTNQ
0 5 S486-p GQRRHtLsEVTNQLV
1 1 S512-p NDSPSLDsVDSEYDM
0 1 S521 DSEYDMGSVQRDLNF
0 1 N532 DLNFLEDNPsLkDIM
1 9 S534-p NFLEDNPsLkDIMLA
0 1 K536-ub LEDNPsLkDIMLANQ
0 1 S545-p IMLANQPsPRMTSPF
1 2 S576-p KREVHNRsPVSFREG
3 35 S587-p FREGRRAsDtsLTQG
0 3 T589-p EGRRAsDtsLTQGIV
0 2 S590-p GRRAsDtsLTQGIVA
0 1 K692-ub QKPSLLSkAQNTCQL
0 1 Y700-p AQNTCQLyCKEPPRS
  mouse

 
T25 GFYDIEGTLGKGNFA
K53 VAIKIIDKSQLDAVN
Y65 AVNLEKIYREVQIMK
S90 YQVMETKSMLYLVTE
K144 KVVHRDLKAENLLLD
T175 KTGELLATWCGSPPY
S179 LLATWCGSPPYAAPE
Y283 PVQRPILYPQEQENE
S343-p RLKSHRSsFPVEQRL
S358-p DGRQRRPstIAEQTV
T359-p GRQRRPstIAEQTVA
P379 GLPVTLHPPNVRLMR
T484-p RSGQRRHtLsEVTNQ
S486-p GQRRHtLsEVTNQLV
S512-p SDNPSLEsVDSEYDM
S521-p DSEYDMGsAQRDLNF
S532-p DLNFLEDsPsLKDIM
S534-p NFLEDsPsLKDIMLA
K536 LEDsPsLKDIMLANQ
S545 IMLANQPSPRMTSPF
S576 KREAHNRSPVSFREG
S587-p FREGRRAsDTsLTQG
T589 EGRRAsDTsLTQGIV
S590-p GRRAsDTsLTQGIVA
K692 QKPNLLPKAQSPCPV
Y700 AQSPCPVYCKEPPRS
  rat

 
T25 GFYDIEGTLGKGNFA
K53 VAIKIIDKSQLDAVN
Y65 AVNLEKIYREVQIMK
S90 YQVMETKSMLYLVTE
K144 KVVHRDLKAENLLLD
T175-p KTGELLAtWCGsPPY
S179-p LLAtWCGsPPYAAPE
Y283 PVQRPILYPQEQENE
S343 RLKSHRSSFPVEQRL
S358 DGRQRRPSTIAEQTV
T359 GRQRRPSTIAEQTVA
P379 GLPVTLHPPNLRLMR
T484-p RSGQRRHtLSEVTNQ
S486 GQRRHtLSEVTNQLV
S512 SDSPSLDSVDSEYDM
S521 DSEYDMGSAQRDLNF
S532 DLNFPEDSPSLKDIM
S534 NFPEDSPSLKDIMLA
K536 PEDSPSLKDIMLANQ
S545 IMLANQPSPRMTPFI
S575 RREAHNRSPVSFREG
S586-p FREGRRAsDTPLTQG
T588 EGRRAsDTPLTQGIV
P589 GRRAsDTPLTQGIVA
K691 QKPSLLPKAQNACPM
Y699 AQNACPMYCKEPPRS
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